Compile Data Set for Download or QSAR
Report error Found 671 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [L858R]'
TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 50322823BDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 0.0200nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 112499BDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 0.0300nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 199995BDBM199995(US9670231, 1.34 | US9670231, 1.3)
Affinity DataIC50: 0.0790nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200809BDBM200809(US9670231, 2.6)
Affinity DataIC50: 0.0850nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790026BDBM790026(2-[(10S,17E)-12-ethyl-8,10,16-trimethyl- 2,8,10,11...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790007BDBM790007(2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 504403BDBM504403(US11040984, Compound 3)
Affinity DataIC50: 0.100nMAssay Description:Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 199967BDBM199967(BDBM200762 | US9670231, 1.1)
Affinity DataIC50: 0.110nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790077BDBM790077({[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl...)
Affinity DataIC50: 0.120nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200501BDBM200501(US9670231, 1.29)
Affinity DataIC50: 0.140nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200497BDBM200497(US9670231, 1.25)
Affinity DataIC50: 0.150nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200810BDBM200810(US9670231, 2.7)
Affinity DataIC50: 0.150nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200336BDBM200336(US9670231, 1.12)
Affinity DataIC50: 0.160nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200793BDBM200793(US9670231, 1.74)
Affinity DataIC50: 0.170nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790039BDBM790039(2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2...)
Affinity DataIC50: 0.220nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790100BDBM790100(2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2...)
Affinity DataIC50: 0.220nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200490BDBM200490(US9670231, 1.22)
Affinity DataIC50: 0.230nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200491BDBM200491(US9670231, 1.23)
Affinity DataIC50: 0.240nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200548BDBM200548(US9670231, 1.51)
Affinity DataIC50: 0.240nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 199967BDBM199967(BDBM200762 | US9670231, 1.1)
Affinity DataIC50: 0.25nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200478BDBM200478(US9670231, 1.18)
Affinity DataIC50: 0.25nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200795BDBM200795(US9670231, 1.75)
Affinity DataIC50: 0.260nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200477BDBM200477(US9670231, 1.17)
Affinity DataIC50: 0.260nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200488BDBM200488(US9670231, 1.20)
Affinity DataIC50: 0.270nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200487BDBM200487(US9670231, 1.19)
Affinity DataIC50: 0.270nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790106BDBM790106(2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,1...)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200489BDBM200489(US9670231, 1.21)
Affinity DataIC50: 0.280nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200801BDBM200801(US9670231, 2.2)
Affinity DataIC50: 0.290nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200218BDBM200218(US9670231, 1.9)
Affinity DataIC50: 0.300nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790106BDBM790106(2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,1...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 765138BDBM765138(US12391671, Compound 022)
Affinity DataIC50: 0.300nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio), inhibitors and DMSO n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200499BDBM200499(US9670231, 1.27)
Affinity DataIC50: 0.310nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200630BDBM200630(US9670231, 1.58)
Affinity DataIC50: 0.310nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790041BDBM790041((2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8...)
Affinity DataIC50: 0.340nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790085BDBM790085((2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-tri...)
Affinity DataIC50: 0.350nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200584BDBM200584(US9670231, 1.55)
Affinity DataIC50: 0.350nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200800BDBM200800(US9670231, 2.1)
Affinity DataIC50: 0.380nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790061BDBM790061(2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8...)
Affinity DataIC50: 0.380nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200538BDBM200538(US9670231, 1.47)
Affinity DataIC50: 0.390nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 50399676BDBM50399676(CHEMBL2178352 | US9096601, 8-26)
Affinity DataIC50: 0.400nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 173435BDBM173435(US9096601, 8-9)
Affinity DataIC50: 0.400nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200600BDBM200600(US9670231, 1.56)
Affinity DataIC50: 0.400nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 173430BDBM173430(US9096601, 8-6 | US9096601, 8-4)
Affinity DataIC50: 0.400nMAssay Description:The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 494877BDBM494877(US10994015, Example 11)
Affinity DataIC50: 0.400nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200503BDBM200503(US9670231, 1.31)
Affinity DataIC50: 0.440nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 790036BDBM790036(2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)o...)
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/11/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 5447BDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 0.458nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 149404BDBM149404(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Affinity DataIC50: 0.460nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 200502BDBM200502(US9670231, 1.30)
Affinity DataIC50: 0.460nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandChemical structure of BindingDB Monomer ID 199996BDBM199996(US9670231, 1.4)
Affinity DataIC50: 0.460nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

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