Compile Data Set for Download or QSAR
Report error Found 229 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [T790M]'
TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 149404BDBM149404(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Affinity DataIC50: 1.30nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 149404BDBM149404(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Affinity DataIC50: 1.30nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 149404BDBM149404(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Affinity DataIC50: 2.10nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228125BDBM228125(US9556191, example 32 | (e)-n-(4-((3,4-dichloro-2-...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 270538BDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 4.08nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228117BDBM228117(US9556191, example 24 | (e)-n-(4-((3-chloro-4-(pyr...)
Affinity DataIC50: 4.20nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 391733BDBM391733(US10300058, Compound 3 | N-(3-((2-((4-(1-acetyl-1,...)
Affinity DataIC50: 4.70nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228126BDBM228126(US9556191, example 33 | (e)-n-(4-((3,4-dichloro-2-...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 270544BDBM270544(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Affinity DataIC50: 5.13nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 391731BDBM391731(US10300058, Compound 1 | pyrimidin-4-yl)amino)pyri...)
Affinity DataIC50: 5.70nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228118BDBM228118(US9556191, example 25 | (e)-n-(4-((3-chloro-4-(pyr...)
Affinity DataIC50: 5.90nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228109BDBM228109(US9556191, example 3 | (e)-n-(4-((3-chloro-4-fluor...)
Affinity DataIC50: 6.20nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 391732BDBM391732(US10300058, Compound 2 | acrylamide )
Affinity DataIC50: 6.20nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228124BDBM228124(US9556191, example 31 | (e)-n-(4-((3,4-dichloro-2-...)
Affinity DataIC50: 6.40nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228110BDBM228110(US9556191, example 5 | (e)-n-(4-((3-chloro-4-fluor...)
Affinity DataIC50: 6.80nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228127BDBM228127(US9556191, example 34 | (e)-n-(4-((3,4-dichloro-2-...)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 391735BDBM391735(US10300058, Compound 4 | N-(6-((2-((4-(1-acetylpip...)
Affinity DataIC50: 7.20nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228107BDBM228107(US9556191, example 1 | (E)-N-(4-((3-Chloro-4-fluo...)
Affinity DataIC50: 8.30nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228116BDBM228116(US9556191, example 23 | (e)-n-(4-((3-chloro-4-(pyr...)
Affinity DataIC50: 8.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228111BDBM228111(US9556191, example 6 | (e)-n-(4-((3-chloro-4-fluor...)
Affinity DataIC50: 8.70nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 391736BDBM391736(US10300058, Compound 5 | N-(6-((2-((4-(1-acetyl-1,...)
Affinity DataIC50: 8.90nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 397143BDBM397143(US9987276, Compound I-2 | US10596172, Compound I-8...)
Affinity DataIC50: 10nMAssay Description:EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 397288BDBM397288(US9987276, Compound I-3 | US10596172, Compound I-3...)
Affinity DataIC50: 10nMAssay Description:EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 397173BDBM397173(US9987276, Compound I-96 | US10596172, Compound I-...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 397288BDBM397288(US9987276, Compound I-3 | US10596172, Compound I-3...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 397144BDBM397144(US9987276, Compound I-4 | US9987276, Compound I-36...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 397173BDBM397173(US9987276, Compound I-96 | US10596172, Compound I-...)
Affinity DataIC50: 10nMAssay Description:EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 397144BDBM397144(US9987276, Compound I-4 | US9987276, Compound I-36...)
Affinity DataIC50: 10nMAssay Description:EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 397143BDBM397143(US9987276, Compound I-2 | US10596172, Compound I-8...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 195864BDBM195864(US9670213, Compound 009 4-(dimethylamino)-N-(4-(2-...)
Affinity DataIC50: 11nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 270543BDBM270543(US10059688, Example 115 | US9783524, Example 115)
Affinity DataIC50: 12nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228113BDBM228113(US9556191, example 20 | (e)-n-(4-((3-chloro-4-fluo...)
Affinity DataIC50: 12.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 391734BDBM391734(US10300058, Compound 11 | N-(3-((2-((2-acetyl-7-me...)
Affinity DataIC50: 13nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228121BDBM228121(US9556191, example 28 | (e)-n-(7-ethoxy-4-((1-(3-f...)
Affinity DataIC50: 14.5nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 270540BDBM270540(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Affinity DataIC50: 15nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 270542BDBM270542(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Affinity DataIC50: 15nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228108BDBM228108(US9556191, example 2 | (e)-n-(4-((3-chloro-4-fluor...)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 270541BDBM270541(US10059688, Example 74)
Affinity DataIC50: 16nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 195861BDBM195861(US9670213, Compound 006 N-(3-(2-(4-methoxyphenylam...)
Affinity DataIC50: 19nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 378885BDBM378885(US10266537, Compound 93)
Affinity DataIC50: 19nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228128BDBM228128(US9556191, example 35 | (e)-n-(4-((3-chloro-2,4-di...)
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 5447BDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 22.5nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228112BDBM228112(US9556191, example 7 | (e)-n-(4-((3-chloro-4-fluor...)
Affinity DataIC50: 22.6nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228120BDBM228120(US9556191, example 27 | (e)-n-(4-((1-(3-fluorobenz...)
Affinity DataIC50: 22.9nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 270539BDBM270539(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Affinity DataIC50: 23nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 228115BDBM228115(US9556191, example 22 | (e)-n-(4-((3-chloro-4-(pyr...)
Affinity DataIC50: 47.3nMpH: 7.5 T: 2°CAssay Description:Materials used include HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid), Brij-35 (dodecyl polyglycol ether), DTT (dithiothreitol), EDTA (et...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50171878BDBM50171878(CHEMBL3805039 | US10106508, Compound I-35)
Affinity DataIC50: 50nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50171879BDBM50171879(CHEMBL3805774 | US10106508, Compound I-36)
Affinity DataIC50: 50nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50171880BDBM50171880(CHEMBL3804868 | US10106508, Compound I-37)
Affinity DataIC50: 50nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Xuanzhu Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 50171910BDBM50171910(CHEMBL3806110 | US10106508, Compound I-30)
Affinity DataIC50: 50nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

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