Compile Data Set for Download or QSAR
Report error Found 1146 Enz. Inhib. hit(s) with Target = 'Gag-Pol polyprotein [588-1027]/[588-1147]'
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 3386BDBM3386(7-[2-(1H-Imidazol-l-yl)-5-methylimidazo[1,5-b]pyri...)
Affinity DataIC50: 0.600nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1890BDBM1890(PETT deriv. 21 | N-(2-(2,6-Difluorophenyl)ethyl)-N...)
Affinity DataIC50: 1nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2132BDBM2132(N-[2-(2-Cyano-6-fluoro-3-methoxyphenethyl)]-N-[2-(...)
Affinity DataIC50: 1nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1890BDBM1890(PETT deriv. 21 | N-(2-(2,6-Difluorophenyl)ethyl)-N...)
Affinity DataIC50: 1nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1890BDBM1890(PETT deriv. 21 | N-(2-(2,6-Difluorophenyl)ethyl)-N...)
Affinity DataIC50: 1nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2139BDBM2139(N-[2-(3,6-Dimethoxy-2-fluorophenethyl)]-N-[2-(5-ch...)
Affinity DataIC50: 1nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2156BDBM2156(N-[2-(N-Phthalimidyl)ethyl]-N-[2-(5-chloropyridyl)...)
Affinity DataIC50: 1nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1317BDBM1317(3-{[(4,7-dichloro-1,3-benzoxazol-2-yl)methyl]amino...)
Affinity DataIC50: 1nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2722BDBM2722(N-[cis-2-(6-Chloro-3-ethoxy-2-fluorophenyl)cyclopr...)
Affinity DataIC50: 1.30nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1944BDBM1944(BHAP deriv. | N-[2-({4-[3-(propan-2-ylamino)pyridi...)
Affinity DataIC50: 1.30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2721BDBM2721(N-[cis-2-(2,6-Difluoro-3-ethoxy)cyclopropyl]-N-[2-...)
Affinity DataIC50: 1.60nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2143BDBM2143(PETT deriv. | 1-(5-chloropyridin-2-yl)-3-[2-(2,4,6...)
Affinity DataIC50: 2nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2159BDBM2159(1-(5-chloropyridin-2-yl)-3-[2-(4,7-dichloro-1,3-di...)
Affinity DataIC50: 2nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2131BDBM2131(N-[2-(2-Cyano-3-ethoxy-6-fluorophenethyl)-N-[2-(5-...)
Affinity DataIC50: 2nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2142BDBM2142(N-[2-(6-Chloro-3-ethoxy-2-fluorophenethyl)]-N-[2-(...)
Affinity DataIC50: 2nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1434BDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataIC50: 2.60nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2723BDBM2723(3-[2-(6-chloro-3-ethoxy-2-fluorophenyl)cyclopropyl...)
Affinity DataIC50: 2.70nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2735BDBM2735((1S,2S)-N-[cis-2-(6-Fluoro-2-hydroxy-3-propionylph...)
Affinity DataIC50: 2.70nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1891BDBM1891(1-[2-(2,6-difluorophenyl)ethyl]-3-(5-methylpyridin...)
Affinity DataIC50: 3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2853BDBM2853(1-(5-chloropyridin-2-yl)-3-(2-phenylethyl)thiourea...)
Affinity DataIC50: 3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2138BDBM2138(1-(5-bromopyridin-2-yl)-3-[2-(2,3-difluoro-6-metho...)
Affinity DataIC50: 3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2870BDBM2870(3-(5-bromopyridin-2-yl)-1-[3-(2,6-difluorophenyl)-...)
Affinity DataIC50: 3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2133BDBM2133(3-[2-(2-cyano-6-fluoro-3-methoxyphenyl)ethyl]-1-(5...)
Affinity DataIC50: 3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1803BDBM1803(2-amino-6-[(3-bromo-5-methylbenzene)sulfonyl]benzo...)
Affinity DataIC50: 3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1436BDBM1436(1-[[2-(benzyloxy)ethoxy]methyl]-5-ethyl-6-(phenylt...)
Affinity DataIC50: 3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2278BDBM2278(5Cl3PhSO2-2IndolCONH2 | 3-(benzenesulfonyl)-5-chlo...)
Affinity DataIC50: 3nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2864BDBM2864(3-(5-bromopyridin-2-yl)-1-[3-(2-methoxyphenyl)-3-o...)
Affinity DataIC50: 3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2717BDBM2717(1-(5-chloropyridin-2-yl)-3-[2-(2-fluoro-3,6-dimeth...)
Affinity DataIC50: 3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2153BDBM2153(3-[2-(2H-1,2,3-benzotriazol-2-yl)ethyl]-1-(5-bromo...)
Affinity DataIC50: 3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2734BDBM2734((1R,2R)-N-[cis-2-(6-Fluoro-2-hydroxy-3-propionylph...)
Affinity DataIC50: 3.20nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2731BDBM2731(1-(5-bromopyridin-2-yl)-3-[2-(3-acetyl-6-fluoro-2-...)
Affinity DataIC50: 3.5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2732BDBM2732((1R,2R)-N-[cis-2-(6-Fluoro-2-hydroxy-3-propionylph...)
Affinity DataIC50: 3.80nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2483BDBM2483(Sustiva | DMP-266 | (4S)-6-chloro-4-(2-cyclopropyl...)
Affinity DataIC50: 4nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2149BDBM2149(1-(5-chloropyridin-2-yl)-3-[2-(3-fluorofuran-2-yl)...)
Affinity DataIC50: 4nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2124BDBM2124(N-[2-(2,6-Difluoro-3-ethoxyphenethyl)]-N-[2-(5-bro...)
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2860BDBM2860(CHEMBL36424 | 1-(5-bromopyridin-2-yl)-3-[2-(2-chlo...)
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2862BDBM2862(3-(5-bromopyridin-2-yl)-1-[3-(2-fluorophenyl)-3-ox...)
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2125BDBM2125(1-(5-bromopyridin-2-yl)-3-{2-[2,6-difluoro-3-(meth...)
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2860BDBM2860(CHEMBL36424 | 1-(5-bromopyridin-2-yl)-3-[2-(2-chlo...)
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 5052BDBM5052(5-bromo-N-[(2Z)-4-chloro-3-methyl-5-(propan-2-yl)-...)
Affinity DataIC50: 4.30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2725BDBM2725(N-[cis-2-(2-Chloro-3-ethoxy-6-fluorophenyl)cyclopr...)
Affinity DataIC50: 4.30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1892BDBM1892(N-(2-(2-Ethoxy-6-fluorophenylethyl)-N -(2-(5-methy...)
Affinity DataIC50: 4.5nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2733BDBM2733((1S,2S)-N-[cis-2-(6-Fluoro-2-hydroxy-3-propionylph...)
Affinity DataIC50: 4.80nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2128BDBM2128(3-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]-1-(5...)
Affinity DataIC50: 5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2325BDBM2325(S-DABO | 2-(cyclopentylsulfanyl)-6-[1-(2,6-difluor...)
Affinity DataIC50: 5nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2134BDBM2134(1-(4-chloro-1,2-dihydropyridazin-1-yl)-3-[2-(2-cya...)
Affinity DataIC50: 5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2129BDBM2129(1-(4-chloro-1,2-dihydropyridazin-1-yl)-3-[2-(2-chl...)
Affinity DataIC50: 5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2140BDBM2140(N-[2-(3-Ethoxy-2-fluoro-6-methoxyphenethyl)]-N-[2-...)
Affinity DataIC50: 5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 1804BDBM1804(2-amino-6-[(3-chloro-5-methylbenzene)sulfonyl]benz...)
Affinity DataIC50: 5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandChemical structure of BindingDB Monomer ID 2135BDBM2135(N-[2-(2,5-Dimethoxyphenethyl)]-N-[2-(5-chloropyrid...)
Affinity DataIC50: 5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
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