Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with Target = 'Gag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I]'
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2137BDBM2137(1-(5-bromopyridin-2-yl)-3-[2-(6-ethoxy-2,3-difluor...)
Affinity DataIC50: 20nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2132BDBM2132(N-[2-(2-Cyano-6-fluoro-3-methoxyphenethyl)]-N-[2-(...)
Affinity DataIC50: 50nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2138BDBM2138(1-(5-bromopyridin-2-yl)-3-[2-(2,3-difluoro-6-metho...)
Affinity DataIC50: 50nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 1890BDBM1890(PETT deriv. 21 | N-(2-(2,6-Difluorophenyl)ethyl)-N...)
Affinity DataIC50: 50nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 1893BDBM1893(N-(2-(2-Ethoxy-6-fluorophenylethyl)-N -(2-(5-bromo...)
Affinity DataIC50: 50nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2133BDBM2133(3-[2-(2-cyano-6-fluoro-3-methoxyphenyl)ethyl]-1-(5...)
Affinity DataIC50: 60nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2139BDBM2139(N-[2-(3,6-Dimethoxy-2-fluorophenethyl)]-N-[2-(5-ch...)
Affinity DataIC50: 80nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2142BDBM2142(N-[2-(6-Chloro-3-ethoxy-2-fluorophenethyl)]-N-[2-(...)
Affinity DataIC50: 90nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2128BDBM2128(3-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]-1-(5...)
Affinity DataIC50: 110nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2483BDBM2483(Sustiva | DMP-266 | (4S)-6-chloro-4-(2-cyclopropyl...)
Affinity DataKi:  120nM ΔG°:  -41.1kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2157BDBM2157(3-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]-1-(5...)
Affinity DataIC50: 130nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2131BDBM2131(N-[2-(2-Cyano-3-ethoxy-6-fluorophenethyl)-N-[2-(5-...)
Affinity DataIC50: 140nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2140BDBM2140(N-[2-(3-Ethoxy-2-fluoro-6-methoxyphenethyl)]-N-[2-...)
Affinity DataIC50: 160nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2124BDBM2124(N-[2-(2,6-Difluoro-3-ethoxyphenethyl)]-N-[2-(5-bro...)
Affinity DataIC50: 170nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2135BDBM2135(N-[2-(2,5-Dimethoxyphenethyl)]-N-[2-(5-chloropyrid...)
Affinity DataIC50: 180nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2859BDBM2859(1-(5-bromopyridin-2-yl)-3-[2-(2-chloro-3-ethoxy-6-...)
Affinity DataIC50: 190nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2145BDBM2145(N-[2-(3-Cyano-4-(dimethylamino)-2-fluorophenethyl)...)
Affinity DataIC50: 210nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2159BDBM2159(1-(5-chloropyridin-2-yl)-3-[2-(4,7-dichloro-1,3-di...)
Affinity DataIC50: 230nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2149BDBM2149(1-(5-chloropyridin-2-yl)-3-[2-(3-fluorofuran-2-yl)...)
Affinity DataIC50: 230nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2146BDBM2146(PETT deriv. | 1-(5-bromopyridin-2-yl)-3-[2-(2,4-di...)
Affinity DataIC50: 240nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 27580BDBM27580(8-[4-(3-chlorophenoxymethyl)phenyl]-8-ethyl-9-oxa-...)
Affinity DataKi:  250nM ΔG°:  -39.2kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2144BDBM2144(1-(5-chloropyridin-2-yl)-3-{2-[4-(dimethylamino)-2...)
Affinity DataIC50: 270nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2156BDBM2156(N-[2-(N-Phthalimidyl)ethyl]-N-[2-(5-chloropyridyl)...)
Affinity DataIC50: 280nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2120BDBM2120(PETT deriv. | 1-(5-chloropyridin-2-yl)-3-[2-(3-cya...)
Affinity DataIC50: 400nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2127BDBM2127(N-[2-(2-Chloro-3-ethoxy-6-fluorophenethyl)]-N-[2-(...)
Affinity DataIC50: 420nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 1866BDBM1866(N-(2-(2-Pyridylethyl))-N -(2-(5-bromopyridyl))thio...)
Affinity DataIC50: 430nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2141BDBM2141(1-(5-bromopyridin-2-yl)-3-[2-(6-fluoro-2,3-dimetho...)
Affinity DataIC50: 430nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2125BDBM2125(1-(5-bromopyridin-2-yl)-3-{2-[2,6-difluoro-3-(meth...)
Affinity DataIC50: 720nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2129BDBM2129(1-(4-chloro-1,2-dihydropyridazin-1-yl)-3-[2-(2-chl...)
Affinity DataIC50: 770nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 27582BDBM27582(8-[4-(3-chlorophenoxymethyl)phenyl]-8-ethyl-9-oxa-...)
Affinity DataKi:  800nM ΔG°:  -36.2kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2143BDBM2143(PETT deriv. | 1-(5-chloropyridin-2-yl)-3-[2-(2,4,6...)
Affinity DataIC50: 810nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 1317BDBM1317(3-{[(4,7-dichloro-1,3-benzoxazol-2-yl)methyl]amino...)
Affinity DataIC50: 850nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2123BDBM2123(N-[2-(2,6-Difluoro-3-methoxyphenethyl)]-N-[2-(5-br...)
Affinity DataIC50: 870nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2134BDBM2134(1-(4-chloro-1,2-dihydropyridazin-1-yl)-3-[2-(2-cya...)
Affinity DataIC50: 1.10E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 12078BDBM12078(6-chloro-4-(cyclohexyloxy)-3-propyl-1,2-dihydroqui...)
Affinity DataIC50: 1.36E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 12080BDBM12080(6-chloro-4-(cyclohexylsulfanyl)-3-propyl-1,2-dihyd...)
Affinity DataIC50: 1.61E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2136BDBM2136(1-(5-bromopyridin-2-yl)-3-[2-(2,5-diethoxyphenyl)e...)
Affinity DataIC50: 1.65E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2121BDBM2121(N-[2-(2,6-Difluoro-3-(dimethylamino)phenethyl)]-N-...)
Affinity DataIC50: 1.90E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2122BDBM2122(1-(5-bromopyridin-2-yl)-3-{2-[3-(dimethylamino)-2,...)
Affinity DataIC50: 1.90E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 12079BDBM12079(6-chloro-4-(cyclohexyloxy)-3-(propan-2-yl)-1,2-dih...)
Affinity DataIC50: 1.96E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2153BDBM2153(3-[2-(2H-1,2,3-benzotriazol-2-yl)ethyl]-1-(5-bromo...)
Affinity DataIC50: 2.00E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2118BDBM2118(3-(2-{[(5-bromopyridin-2-yl)carbamothioyl]amino}et...)
Affinity DataIC50: 2.00E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2119BDBM2119(N-[2-(3-(Acetamidomethyl)-2,6-difluorophenethyl)]-...)
Affinity DataIC50: 2.00E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 12081BDBM12081(6-chloro-4-(cyclohexanesulfinyl)-3-propyl-1,2-dihy...)
Affinity DataIC50: 2.38E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2006
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2154BDBM2154(1-(5-bromopyridin-2-yl)-3-[2-(5,6-dimethyl-2H-1,2,...)
Affinity DataIC50: 2.50E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2155BDBM2155(N-[2-(2-Benzimidazolyl)ethyl]-N-[2-(5-bromopyridyl...)
Affinity DataIC50: 2.50E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2151BDBM2151(1-(5-bromopyridin-2-yl)-3-[2-(1H-indol-3-yl)ethyl]...)
Affinity DataIC50: 2.50E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2152BDBM2152(1-(5-bromopyridin-2-yl)-3-[2-(5-methoxy-1H-indol-3...)
Affinity DataIC50: 2.50E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2150BDBM2150(N-[2-[2-(3-Cyanofuranyl)]ethyl]-N-[2-(5-chloropyri...)
Affinity DataIC50: 2.60E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandChemical structure of BindingDB Monomer ID 2148BDBM2148(N-[2-[2-(1-Methylpyrrolyl)]ethyl]-N-[2-(5-chloropy...)
Affinity DataIC50: 2.70E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
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