Compile Data Set for Download or QSAR
Report error Found 5249 Enz. Inhib. hit(s) with Target = 'Galectin'
TargetGalectin-8(Human)
National Institute of Advanced Industrial Science and Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50336203(12-Mercaptododecyl-beta-D-galactopyranosyl-(1->4)-...)
Affinity DataKd:  0.233nMAssay Description:Binding affinity to human galectin-8 component 1 by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetGalectin-8(Human)
National Institute of Advanced Industrial Science and Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50336203(12-Mercaptododecyl-beta-D-galactopyranosyl-(1->4)-...)
Affinity DataKd:  0.233nMAssay Description:Binding affinity to human galectin-8 component 1 by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM653576(US20240059728, Example 2 | 3-[4-(4-Chloro-3,5-difl...)
Affinity DataKd:  0.300nMAssay Description:The affinity of Example 1-14 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM653575(3,3′-Dideoxy-3-[4-(3,4,5-trifluorophenyl)-1H...)
Affinity DataKd:  0.400nMAssay Description:The affinity of Example 1-14 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247478(CHEMBL4066068)
Affinity DataKd: <1nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM468295(US10800804, Example SX | 3,3′-Dideoxy-3,3...)
Affinity DataKd:  1nMAssay Description:The affinity of compounds S8a-c, S11, S16, S20a-b and S21 for galectins were determined by a fluorescence anisotropy assay where the compound was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM468290(US10800804, Example S11 | 3-{4-[(Butylamino)carbon...)
Affinity DataKd:  1nMAssay Description:The affinity of compounds S8a-c, S11, S16, S20a-b and S21 for galectins were determined by a fluorescence anisotropy assay where the compound was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM653577(US20240059728, Example 3 | 3′-[4-(2-Aminothi...)
Affinity DataKd:  1nMAssay Description:The affinity of Example 1-14 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247477(CHEMBL4102995)
Affinity DataKd: <1nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM468297(US10800804, Example 3b)
Affinity DataKd:  1nMAssay Description:The affinity of compounds 3a-c for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247479(CHEMBL4104417)
Affinity DataKd: <1nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM455404(3,3′-Dideoxy-3-[4-(tetrahydropyran-4-yl)-1H-...)
Affinity DataKd:  1nMAssay Description:The affinity of Example 1-5 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM468295(US10800804, Example SX | 3,3′-Dideoxy-3,3...)
Affinity DataKd:  1nMAssay Description:The affinity of compounds S8a-c, S11, S16, S20a-b and S21 for galectins were determined by a fluorescence anisotropy assay where the compound was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50635335(CHEMBL5512479)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247477(CHEMBL4102995)
Affinity DataKd:  1.10nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxybenzamido)-1,1'-sulfanediyl-di-beta-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-8(Human)
National Institute of Advanced Industrial Science and Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50336204(12-Mercaptododecyl-beta-D-galactopyranosyl-(1->4)-...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to human galectin-8 component 1 by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetGalectin-8(Human)
National Institute of Advanced Industrial Science and Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50336204(12-Mercaptododecyl-beta-D-galactopyranosyl-(1->4)-...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to human galectin-8 component 1 by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247478(CHEMBL4066068)
Affinity DataKd:  1.60nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxybenzamido)-1,1'-sulfanediyl-di-beta-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247479(CHEMBL4104417)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to human galectin 3 C-terminal domain expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM455401(3,3'-Dideoxy-3- [4-(morpholin-4- yl)-1H-1,2,3- tri...)
Affinity DataKd:  2nMAssay Description:The affinity of Example 1-5 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM560370(US11377464, Example 42 | 3,4-Dichlorophenyl 3- deo...)
Affinity DataKd:  2nMAssay Description:The assay was adapted to be able to measure the high affinity of compounds for galectin-3 by using the below probe constructed to have high affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM468298(US10800804, Example 3c)
Affinity DataKd:  2nMAssay Description:The affinity of compounds 3a-c for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM455405(3,3′-Dideoxy-3-[4-(propan-2-yl)-1H-1,2,3-tri...)
Affinity DataKd:  2nMAssay Description:The affinity of Example 1-5 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM468288(US10800804, Example S8b | 3′-Deoxy-3-O-[(5,6...)
Affinity DataKd:  2nMAssay Description:The affinity of compounds S8a-c, S11, S16, S20a-b and S21 for galectins were determined by a fluorescence anisotropy assay where the compound was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM461847(3,4-Dichlorophenyl 3-deoxy-3-[4-(2,3,4,5,6-pentafl...)
Affinity DataKd:  2nMAssay Description:The affinity of Example 1-106 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50581762(OLITIGALTIN | Olitigaltin | Td 139 | Td-139 | Td13...)
Affinity DataKd:  2.20nMAssay Description:Binding affinity at recombinant human Galectin-3 assessed as dissociation constant by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247479(CHEMBL4104417)
Affinity DataKd:  2.30nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxybenzamido)-1,1'-sulfanediyl-di-beta-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247476(CHEMBL4091143)
Affinity DataKd:  2.30nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50581762(OLITIGALTIN | Olitigaltin | Td 139 | Td-139 | Td13...)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to galectin-3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247476(CHEMBL4091143)
Affinity DataKd:  2.30nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxybenzamido)-1,1'-sulfanediyl-di-beta-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247482(CHEMBL4065371)
Affinity DataKd:  2.70nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247477(CHEMBL4102995)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to human galectin 3 C-terminal domain expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50591134(CHEMBL5181494)
Affinity DataKd:  3nMAssay Description:Binding affinity to human galectin-3 assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGalectin-1(Human)
Galecto Biotech

US Patent
LigandPNGBDBM653575(3,3′-Dideoxy-3-[4-(3,4,5-trifluorophenyl)-1H...)
Affinity DataKd:  3nMAssay Description:The affinity of Example 1-14 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM468296(US10800804, Example 3a | 3,3′-dideoxy-3,3...)
Affinity DataKd:  3nMAssay Description:The affinity of compounds 3a-c for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM468294(US10800804, Example S21 | 3,3′-Dideoxy-3-[4-...)
Affinity DataKd:  3nMAssay Description:The affinity of compounds S8a-c, S11, S16, S20a-b and S21 for galectins were determined by a fluorescence anisotropy assay where the compound was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247478(CHEMBL4066068)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to human galectin 3 C-terminal domain expressed in Escherichia coli BL21(DE3) by competitive isothermal titration calorimetric analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247482(CHEMBL4065371)
Affinity DataKd:  4nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxybenzamido)-1,1'-sulfanediyl-di-beta-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-1(Human)
Galecto Biotech

US Patent
LigandPNGBDBM653576(US20240059728, Example 2 | 3-[4-(4-Chloro-3,5-difl...)
Affinity DataKd:  4nMAssay Description:The affinity of Example 1-14 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetGalectin-1(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50635335(CHEMBL5512479)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50247480(CHEMBL4064035)
Affinity DataKd:  4nMAssay Description:Displacement of 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50581785(CHEMBL5081052)
Affinity DataIC50: 5nMAssay Description:Inhibition of biotin-asialofetuin binding to human Gal3 measured after 90 mins by HTRF competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM455403(3,3′-Dideoxy-3-[4-(piperidin-4-yl)-1H-1,2,3-...)
Affinity DataKd:  5nMAssay Description:The affinity of Example 1-5 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM653579(US20240059728, Example 5 | 1,1′-Sulfanediyl-...)
Affinity DataKd:  6nMAssay Description:The affinity of Example 1-14 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetGalectin-1(Human)
Galecto Biotech

US Patent
LigandPNGBDBM508740(US11046725, Example 16 | 5-Chloro-2-cyano-3-pyridy...)
Affinity DataKd:  6nMAssay Description:The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2021
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM572517(5-Bromo-2-(N-azetidinylcarbamoyl)-3-pyridyl 3-deox...)
Affinity DataKd:  6nMAssay Description:The affinity of Example 1-71 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50645959(CHEMBL5589832)
Affinity DataIC50: 6.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM541746(US11267811, Example A78)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of His-tagged recombinant human Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM541746(US11267811, Example A78)
Affinity DataIC50: 7nMAssay Description:The Gal-3 assays were performed in 384 white Opti plates in three replicates at room temperature with gentle shaking at 250-300 rpmFrom the original ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2022
Entry Details
US Patent

TargetGalectin-3(Human)
Galecto Biotech

US Patent
LigandPNGBDBM50645958(CHEMBL5593643)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
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