Compile Data Set for Download or QSAR
Report error Found 832 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid type B receptor subunit 1'
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550633(CHEMBL4763515)
Affinity DataIC50: 0.200nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50019213(5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benz...)
Affinity DataKi:  0.75nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50019213(5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benz...)
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50019213(5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benz...)
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50108997(CGP-71872 | CHEMBL1628548)
Affinity DataKd:  1nMAssay Description:Binding affinity to GABA-B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
LigandPNGBDBM24185(CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl...)
Affinity DataIC50: 1nMAssay Description:In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article
PDB3D3D Structure (crystal)
LigandPNGBDBM26263(ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...)
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550634(CHEMBL4791366)
Affinity DataIC50: 1.20nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50019213(5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benz...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50243981(CHEMBL453066 | Beta CCM | Methyl Beta-carboline-3 ...)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50243981(CHEMBL453066 | Beta CCM | Methyl Beta-carboline-3 ...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM26263(ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM26263(ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...)
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550631(CHEMBL4756657)
Affinity DataIC50: 2.40nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataKi:  2.75nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50435128(CHEMBL2391908)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
Affinity DataIC50: 3nMAssay Description:In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM81480(CAS_5590 | CAS_118-96-7 | NSC_5590 | Triton,(-) | ...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550632(CHEMBL4787614)
Affinity DataIC50: 4.90nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM25878(Flunitrazepam | [3H]Rohypnol | 5-(2-fluorophenyl)-...)
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
In Depth
Date in BDB:
2/29/2012
Entry Details
PubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
Affinity DataIC50: 5nMAssay Description:Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
Affinity DataKi:  5.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of [3H]CGP-27492 binding to Gamma-aminobutyric acid type B receptor of rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM25878(Flunitrazepam | [3H]Rohypnol | 5-(2-fluorophenyl)-...)
Affinity DataKi:  6.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50435128(CHEMBL2391908)
Affinity DataIC50: 6.40nMAssay Description:Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24185(CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
Affinity DataKi:  6.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM25878(Flunitrazepam | [3H]Rohypnol | 5-(2-fluorophenyl)-...)
Affinity DataKi:  7.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50108998(CHEMBL3600560)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at human recombinant GABA-B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
LigandPNGBDBM25878(Flunitrazepam | [3H]Rohypnol | 5-(2-fluorophenyl)-...)
Affinity DataKi:  8.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM81480(CAS_5590 | CAS_118-96-7 | NSC_5590 | Triton,(-) | ...)
Affinity DataKi:  9.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
LigandPNGBDBM104978(US8575375, C-8)
Affinity DataIC50: 9.79nMAssay Description:[35S]TBPS binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

LigandPNGBDBM403332(US10329320, Compound 9)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM585870(US11530237, Compound 28 | US11542297, Compound 28)
Affinity DataIC50: 10nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM403333(US10329320, Compound 10)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM585871(US11530237, Compound 29 | US11542297, Compound 29)
Affinity DataIC50: 10nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM403334(US10329320, Compound 11)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM585868(US11530237, Compound 26 | US11542297, Compound 26)
Affinity DataIC50: 10nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM25878(Flunitrazepam | [3H]Rohypnol | 5-(2-fluorophenyl)-...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM403335(US10329320, Compound 12)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM403328(US10329320, Compound 1 | US10329320, Compound 2)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM585874(US11530237, Compound 32)
Affinity DataIC50: 10nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

LigandPNGBDBM403328(US10329320, Compound 1 | US10329320, Compound 2)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM403330(US10329320, Compound 7)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM403331(US10329320, Compound 8)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

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