Compile Data Set for Download or QSAR
Report error Found 9175 Enz. Inhib. hit(s) with Target = 'Genome polyprotein'
TargetGenome polyprotein [1973-2419](HCV)
TBA

US Patent
LigandPNGBDBM244109(US9428491, 1.2: 2HCl)
Affinity DataIC50: 0.000790nMT: 2°CAssay Description:Solutions of the tested compounds in DMEM medium {DMEM) 1x; Source: Cellgro; Catalogue: 10-013-CV} were prepared immediately before use. Eleven seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458023(CHEMBL4214282)
Affinity DataEC50:  0.000800nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH-1 infected in human Huh7.5.1 cells assessed as reduction in viral replication after 3 days by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453103(CHEMBL4218872)
Affinity DataEC50:  0.00100nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 4a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453103(CHEMBL4218872)
Affinity DataEC50:  0.00100nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 3a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453103(CHEMBL4218872)
Affinity DataEC50:  0.00100nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 5a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM516578(US11053243, Example 189b | methyl [(2S)-1-{(2S)-2-...)
Affinity DataEC50:  0.00100nMAssay Description:Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458020(CHEMBL4203791)
Affinity DataEC50:  0.00110nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH-1 infected in human Huh7.5.1 cells assessed as reduction in viral replication after 3 days by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453100(A-1325912.0 | ABT-530 | Pibrentasvir)
Affinity DataEC50:  0.00140nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 5a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453112(CHEBI:85183 | ABT-267 | Ombitasvir)
Affinity DataEC50:  0.00170nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 4a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein [1973-2419](HCV)
TBA

US Patent
LigandPNGBDBM244111(US9428491, 1.4: 2HCl)
Affinity DataIC50: 0.00180nMT: 2°CAssay Description:Solutions of the tested compounds in DMEM medium {DMEM) 1x; Source: Cellgro; Catalogue: 10-013-CV} were prepared immediately before use. Eleven seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453100(A-1325912.0 | ABT-530 | Pibrentasvir)
Affinity DataEC50:  0.00190nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 4a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453100(A-1325912.0 | ABT-530 | Pibrentasvir)
Affinity DataEC50:  0.00190nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2b assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein [1657-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM245926(US9433609, 19)
Affinity DataEC50:  0.00200nMAssay Description:In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [810-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243434(US9427428, 19)
Affinity DataEC50:  0.00200nMAssay Description:In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM516573(tert-butyl {(1R)-2-[(2S)-2-({4-[5-({[(2S)-1-{(2R)-...)
Affinity DataEC50:  0.00200nMAssay Description:Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetGenome polyprotein [810-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243449(US9433609, 13 | US9427428, 13)
Affinity DataEC50:  0.00200nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1657-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243449(US9433609, 13 | US9427428, 13)
Affinity DataEC50:  0.00200nMAssay Description:In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1973-2419](HCV)
TBA

US Patent
LigandPNGBDBM244105(US9428491, 1.10: 2HCl)
Affinity DataIC50: 0.00200nMT: 2°CAssay Description:Solutions of the tested compounds in DMEM medium {DMEM) 1x; Source: Cellgro; Catalogue: 10-013-CV} were prepared immediately before use. Eleven seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453109(CHEMBL4205352)
Affinity DataEC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 5a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50147212(CHEMBL3765311 | US11053243, Example 192)
Affinity DataEC50:  0.00200nMAssay Description:Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453117(CHEMBL4211486)
Affinity DataEC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 5a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453103(CHEMBL4218872)
Affinity DataEC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2b assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein [1657-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243449(US9433609, 13 | US9427428, 13)
Affinity DataEC50:  0.00200nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453100(A-1325912.0 | ABT-530 | Pibrentasvir)
Affinity DataEC50:  0.00210nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 3a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453100(A-1325912.0 | ABT-530 | Pibrentasvir)
Affinity DataEC50:  0.00230nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458018(CHEMBL4216436)
Affinity DataEC50:  0.00250nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH-1 infected in human Huh7.5.1 cells assessed as reduction in viral replication after 3 days by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50453112(CHEBI:85183 | ABT-267 | Ombitasvir)
Affinity DataEC50:  0.00260nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH-1 infected in human Huh7.5.1 cells assessed as reduction in viral replication after 3 days by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453100(A-1325912.0 | ABT-530 | Pibrentasvir)
Affinity DataEC50:  0.00280nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 6a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453109(CHEMBL4205352)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 3a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein [1657-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243451(US9433609, 15 | US9427428, 15)
Affinity DataEC50:  0.00300nMAssay Description:In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1657-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243452(US9433609, 16 | US9427428, 16)
Affinity DataEC50:  0.00300nMAssay Description:In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453115(CHEMBL4203712)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453103(CHEMBL4218872)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453109(CHEMBL4205352)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453103(CHEMBL4218872)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453103(CHEMBL4218872)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 6a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453109(CHEMBL4205352)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 4a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein [810-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243446(US9433609, 8 | US9427428, 8)
Affinity DataEC50:  0.00300nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1973-2419,Y2165C](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243436(US9427428, 21 | US9427428, 17)
Affinity DataEC50:  0.00300nMAssay Description:In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1973-2419,Y2165C](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243437(US9427428, 18)
Affinity DataEC50:  0.00300nMAssay Description:In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [810-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243437(US9427428, 18)
Affinity DataEC50:  0.00300nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [810-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243434(US9427428, 19)
Affinity DataEC50:  0.00300nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1657-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243446(US9433609, 8 | US9427428, 8)
Affinity DataEC50:  0.00300nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [810-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243452(US9433609, 16 | US9427428, 16)
Affinity DataEC50:  0.00300nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453109(CHEMBL4205352)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2b assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453108(CHEMBL4202479)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein [810-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243451(US9433609, 15 | US9427428, 15)
Affinity DataEC50:  0.00300nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1657-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM245925(US9433609, 18)
Affinity DataEC50:  0.00300nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [1657-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM245926(US9433609, 19)
Affinity DataEC50:  0.00300nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [810-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243445(US9433609, 7 | US9427428, 7)
Affinity DataEC50:  0.00300nMAssay Description:In a transient set-up, a Huh-7 lunet hepatoma cell line was transiently transfected with an autonomously replicating RNA encoding a bi-cistronic expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

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