Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with Target = 'Ionotropic glutamate receptor NMDA 1/2C'
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663373BDBM50663373(CHEMBL562641)
Affinity DataEC50:  3nMAssay Description:Partial agonist activity at recombinant wild-type human GluN1/2C expressed in Xenopus laevis oocytes by TEVC recording methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664811BDBM50664811(CHEMBL6173708)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at recombinant human GluN1/2C expressed in Xenopus laevis oocytes in presence of glycine/glutamate by TEVC recording methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 557694BDBM557694(US11466027, Compound 1e | US11358971, Compound 1c)
Affinity DataEC50:  120nMAssay Description:Agonist activity at recombinant human GluN1/2C expressed in Xenopus laevis oocytes by TEVC recording methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597430BDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2C receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663375BDBM50663375(CHEMBL6159574)
Affinity DataEC50:  320nMAssay Description:Agonist activity at GluN1/GluN2C (unknown origin) expressed in xenopus laevis oocytes by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664814BDBM50664814(CHEMBL6146530)
Affinity DataEC50:  360nMAssay Description:Agonist activity at recombinant human GluN1/2C expressed in Xenopus laevis oocytes by TEVC recording methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50498430BDBM50498430(CHEMBL3594112)
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant GluN1/GluN2C receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of glutamate-evoked current by whol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663374BDBM50663374(CHEMBL6163634)
Affinity DataEC50:  1.97E+3nMAssay Description:Agonist activity at GluN1/GluN2C (unknown origin) expressed in xenopus laevis oocytes by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103516BDBM50103516(CHEBI:40009 | Cycloserine | Seromycin)
Affinity DataEC50:  4.50E+3nMAssay Description:Agonist activity at recombinant human GluN1/2C expressed in Xenopus laevis oocytes by TEVC recording methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205849BDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  4.70E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2C receptor (unknown origin) assessed as increase in glutamate-induced calcium flux measured at time inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50164398BDBM50164398(CHEMBL3799213)
Affinity DataEC50:  7.40E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2C NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 436689BDBM436689(US10617676, Example 20 | N-Cyclopropyl-2-[2-oxo-6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2C expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 409486BDBM409486(N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2C expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599751BDBM50599751(CHEMBL5092058)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at GluN1a/GluN2C (unknown origin) expressed in CHO cells in presence of glutamate by Ca2+ influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666968BDBM50666968(CHEMBL6163935)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666969BDBM50666969(CHEMBL6176593)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666970BDBM50666970(CHEMBL6177304)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666971BDBM50666971(CHEMBL6176863)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666965BDBM50666965(CHEMBL6176778)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666976BDBM50666976(JNJ-78911118 | CHEMBL6176014)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666977BDBM50666977(CHEMBL6176303)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666978BDBM50666978(CHEMBL6174828)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666979BDBM50666979(CHEMBL6175398)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666972BDBM50666972(CHEMBL6174428)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666973BDBM50666973(CHEMBL6163649)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666974BDBM50666974(CHEMBL6177012)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50259886BDBM50259886(CHEMBL2333943)
Affinity DataIC50: 6.80E+4nMAssay Description:Negative allosteric modulation of GluN1a/GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glutamate/glyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed