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Report error Found 14 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2 [Y641N]'
TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM190202(US9175331, 32 | EPZ008337 | US12390472, Example EP...)
Affinity DataIC50: 0.5nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764976(3-(ethyl(tetrahydro-2H-pyran-4-yl) amino)-N-((4-me...)
Affinity DataIC50: 0.510nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764975(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.510nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM50594148(CHEMBL5207948 | US12390472, Example 91)
Affinity DataIC50: 0.600nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 1nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764973(3-((8-oxabicyclo[3.2.1]octan-3-yl)(ethyl) amino)-5...)
Affinity DataIC50: 2nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764972(3-((4,4-difluorocyclohexyl)(ethyl)amino)-5-(trans-...)
Affinity DataIC50: 2.60nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764978(3-((4,4-difluorocyclohexyl)(ethyl)amino)-N-((4-hyd...)
Affinity DataIC50: 3.10nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764968(WO2012142513, Compound 194 | tert-butyl 3-(3-(((4,...)
Affinity DataIC50: 3.40nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764969(WO2012142513, Compound 195 | 5-(azetidin-3-yloxy)-...)
Affinity DataIC50: 3.70nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764933(3-((4,4-difluorocyclohexyl)(ethyl) amino)-N-((4,6-...)
Affinity DataIC50: 5.20nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764977(3-((4,4-difluorocyclohexyl)(ethyl)amino)-N-((4-hyd...)
Affinity DataIC50: 100nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

LigandPNGBDBM50009672(AdoHcy | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-rib...)
Affinity DataIC50: 380nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

LigandPNGBDBM190225(US9175331, 75)
Affinity DataIC50: 4.10E+3nMpH: 7.6Assay Description:Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL , was plated in a 384 well microtiter plate. Positive control (100% inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent