Compile Data Set for Download or QSAR
Report error Found 3388 Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor'
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185287BDBM50185287(CHEMBL3823268)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122557BDBM122557(US8735386, I-27)
Affinity DataIC50: 0.180nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122627BDBM122627(US8735386, I-97)
Affinity DataIC50: 0.190nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122640BDBM122640(US8735386, I-110)
Affinity DataIC50: 0.190nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122699BDBM122699(US8735386, I-169)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265871BDBM50265871(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-4,4-di...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122701BDBM122701(US8735386, I-171)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122952BDBM122952(US8735386, IV-5)
Affinity DataIC50: 0.260nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122860BDBM122860(US8735386, III-22)
Affinity DataIC50: 0.270nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27826BDBM27826(4-fluoro-2-[(2-{[2-methoxy-4-(1-propylpiperidin-4-...)
Affinity DataIC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265869BDBM50265869(3-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122703BDBM122703(US8735386, I-173)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122702BDBM122702(US8735386, I-172)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122941BDBM122941(US8735386, III-103)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265847BDBM50265847(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122672BDBM122672(US8735386, I-142)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122951BDBM122951(US8735386, IV-4)
Affinity DataIC50: 0.310nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 482158BDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27825BDBM27825(4-fluoro-2-[(2-{[2-methoxy-4-(1-propylpiperidin-3-...)
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185286BDBM50185286(CHEMBL3823256)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122942BDBM122942(US8735386, III-104)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122706BDBM122706(US8735386, I-176)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122673BDBM122673(US8735386, I-143)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122705BDBM122705(US8735386, I-175)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122704BDBM122704(US8735386, I-174)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122950BDBM122950(US8735386, IV-3)
Affinity DataIC50: 0.430nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185288BDBM50185288(CHEMBL3824326)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265849BDBM50265849(2-(dimethylamino)-1-(7-(4-(indolin-1-yl)-7H-pyrrol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122955BDBM122955(US8735386, IV-8)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27842BDBM27842(4,5-difluoro-2-{[2-({2-methoxy-4-[4-(propan-2-yl)p...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265872BDBM50265872(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122670BDBM122670(US8735386, I-140)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122707BDBM122707(US8735386, I-177)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27793BDBM27793(2-{[2-({5-[2-(dimethylamino)acetamido]-2-methoxy-4...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122708BDBM122708(US8735386, I-178)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122859BDBM122859(US8735386, III-21)
Affinity DataIC50: 0.540nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122898BDBM122898(US8735386, III-60)
Affinity DataIC50: 0.570nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122697BDBM122697(US8735386, I-167)
Affinity DataIC50: 0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122696BDBM122696(US8735386, I-166)
Affinity DataIC50: 0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122712BDBM122712(US8735386, I-182)
Affinity DataIC50: 0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50437357BDBM50437357(CHEMBL3037909)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122711BDBM122711(US8735386, I-181)
Affinity DataIC50: 0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27822BDBM27822(2-[(2-{[2-methoxy-4-(1-propyl-1,2,5,6-tetrahydropy...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122710BDBM122710(US8735386, I-180)
Affinity DataIC50: 0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122709BDBM122709(US8735386, I-179)
Affinity DataIC50: 0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122948BDBM122948(US8735386, IV-1)
Affinity DataIC50: 0.630nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122578BDBM122578(US8735386, I-48)
Affinity DataIC50: 0.690nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 122713BDBM122713(US8735386, I-183)
Affinity DataIC50: 0.700nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265850BDBM50265850(3-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50437358BDBM50437358(CHEMBL3037908)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Displayed 1 to 50 (of 3388 total ) | Next | Last >>
Jump to: