Compile Data Set for Download or QSAR
Report error Found 500 Enz. Inhib. hit(s) with Target = 'Interleukin-1 beta'
TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531296BDBM531296(US11208399, Example 53)
Affinity DataIC50: 0.400nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531223BDBM531223(US11208399, Example 4 | (R)-2-(4-Methyl-6-((1-meth...)
Affinity DataIC50: 0.400nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 65497BDBM65497(CC-220 (Compound 6) | US9694015, 6.4S)
Affinity DataIC50: 0.460nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531253BDBM531253(US11208399, Example 12)
Affinity DataIC50: 0.600nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531331BDBM531331(US11208399, Example 82)
Affinity DataIC50: 0.700nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531289BDBM531289(US11208399, Example 48)
Affinity DataIC50: 0.800nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531332BDBM531332(US11208399, Example 83a)
Affinity DataIC50: 0.800nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531220BDBM531220(US11208399, Example 1 | (R)-2-(6-((1-Ethylpiperidi...)
Affinity DataIC50: 0.800nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531288BDBM531288(US11208399, Example 47)
Affinity DataIC50: 0.800nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531319BDBM531319(US11208399, Example 71)
Affinity DataIC50: 0.800nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 77001BDBM77001(3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoisoin...)
Affinity DataIC50: 0.850nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531230BDBM531230(US11208399, Example 6)
Affinity DataIC50: 0.900nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 50058530BDBM50058530((S)-3-{[(1S,9S)-9-(2-Fluoro-benzoylamino)-6,10-dio...)
Affinity DataKi:  1nMAssay Description:Binding affinity to Interleukin-1beta (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 50058526BDBM50058526((S)-3-{[(1S,9S)-9-(4-Carboxymethoxy-benzoylamino)-...)
Affinity DataKi:  1nMAssay Description:Binding affinity to Interleukin-1beta (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531254BDBM531254(US11208399, Example 13)
Affinity DataIC50: 1.20nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531337BDBM531337(US11208399, Example 85b | 3-Methyl-2-(6-(((1R,2R,5...)
Affinity DataIC50: 1.30nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531252BDBM531252(US11208399, Example 11)
Affinity DataIC50: 1.30nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531354BDBM531354(US11208399, Example 94a | 2-(6-(((3S, 5S)-5-Fluoro...)
Affinity DataIC50: 1.60nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531291BDBM531291(US11208399, Example 49)
Affinity DataIC50: 1.60nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531339BDBM531339(US11208399, Example 86b | 2-(6-(((1S,2S,5S)-8-(2-H...)
Affinity DataIC50: 1.80nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531232BDBM531232(US11208399, Example 7)
Affinity DataIC50: 1.90nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531364BDBM531364(US11208399, Example 101 | (R)-2-(6-((1-Ethylpiperi...)
Affinity DataIC50: 1.90nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531292BDBM531292(US11208399, Example 50)
Affinity DataIC50: 2.30nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 695523BDBM695523(US12084416, Example 21)
Affinity DataIC50: 2.40nMAssay Description:THP1 monocytes were differentiated with PMA (100 ng/mL) and incubated at 37 deg C. for 20 hrs in presence of 5% CO2. 2×105 differentiated cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531323BDBM531323(US11208399, Example 74)
Affinity DataIC50: 2.60nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531293BDBM531293(US11208399, Example 51)
Affinity DataIC50: 2.60nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 695530BDBM695530(US12084416, Example 91)
Affinity DataIC50: 2.90nMAssay Description:THP1 monocytes were differentiated with PMA (100 ng/mL) and incubated at 37 deg C. for 20 hrs in presence of 5% CO2. 2×105 differentiated cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531282BDBM531282(US11208399, Example 41)
Affinity DataIC50: 3nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531224BDBM531224(US11208399, Example 5 | (R)-3-Methyl-2-(5-methyl-6...)
Affinity DataIC50: 3nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531279BDBM531279(US11208399, Example 39)
Affinity DataIC50: 3.20nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531286BDBM531286(US11208399, Example 45)
Affinity DataIC50: 3.20nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531350BDBM531350(US11208399, Example 92a | 2-(6-(((R)-1-((S)-2-Hydr...)
Affinity DataIC50: 3.30nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531318BDBM531318(US11208399, Example 70)
Affinity DataIC50: 3.5nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531351BDBM531351(US11208399, Example 92b | 2-(6-(((R)-1-((R)-2-Hydr...)
Affinity DataIC50: 3.60nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 695533BDBM695533(US12084416, Example 111)
Affinity DataIC50: 4.30nMAssay Description:THP1 monocytes were differentiated with PMA (100 ng/mL) and incubated at 37 deg C. for 20 hrs in presence of 5% CO2. 2×105 differentiated cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531329BDBM531329(US11208399, Example 80)
Affinity DataIC50: 4.70nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 695535BDBM695535(US12084416, Example 127)
Affinity DataIC50: 5.60nMAssay Description:THP1 monocytes were differentiated with PMA (100 ng/mL) and incubated at 37 deg C. for 20 hrs in presence of 5% CO2. 2×105 differentiated cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531310BDBM531310(US11208399, Example 64)
Affinity DataIC50: 5.90nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 695536BDBM695536(US12084416, Example 129)
Affinity DataIC50: 5.90nMAssay Description:THP1 monocytes were differentiated with PMA (100 ng/mL) and incubated at 37 deg C. for 20 hrs in presence of 5% CO2. 2×105 differentiated cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531363BDBM531363(US11208399, Example 100 | (R)-3-Methyl-2-(5-methyl...)
Affinity DataIC50: 6nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 77015BDBM77015((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...)
Affinity DataIC50: 6.20nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531340BDBM531340(US11208399, Example 87a | 2-(6-(((3R,6R)-6-(Hydrox...)
Affinity DataIC50: 6.30nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531352BDBM531352(US11208399, Example 93a | 2-(6-(((3S,5S)-5-Fluorop...)
Affinity DataIC50: 6.60nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531280BDBM531280(US11208399, Example 40)
Affinity DataIC50: 6.80nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531311BDBM531311(US11208399, Example 65)
Affinity DataIC50: 7.40nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 695514BDBM695514(US12084416, Example 4)
Affinity DataIC50: 7.40nMAssay Description:THP1 monocytes were differentiated with PMA (100 ng/mL) and incubated at 37 deg C. for 20 hrs in presence of 5% CO2. 2×105 differentiated cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531360BDBM531360(US11208399, Example 97 | (3S,5R)-5-((6-(2-Hydroxy-...)
Affinity DataIC50: 7.60nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 695526BDBM695526(US12084416, Example 63)
Affinity DataIC50: 8nMAssay Description:THP1 monocytes were differentiated with PMA (100 ng/mL) and incubated at 37 deg C. for 20 hrs in presence of 5% CO2. 2×105 differentiated cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531302BDBM531302(US11208399, Example 56)
Affinity DataIC50: 8.30nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 695528BDBM695528(US12084416, Example 84)
Affinity DataIC50: 8.5nMAssay Description:THP1 monocytes were differentiated with PMA (100 ng/mL) and incubated at 37 deg C. for 20 hrs in presence of 5% CO2. 2×105 differentiated cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

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