Compile Data Set for Download or QSAR
Report error Found 1160 Enz. Inhib. hit(s) with Target = 'Isocitrate dehydrogenase [NADP], mitochondrial [R140Q]'
TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 740764BDBM740764(Preparation of 6-(6-(methylthio)pyridin-2-yl)-N2,N...)
Affinity DataIC50: 21nMAssay Description:A test compound is prepared as 10 mM stock in DMSO and diluted to 50× final concentration in DMSO, for a 50 μl reaction mixture. IDH enzyme activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/19/2025
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 497335BDBM497335(7-[[(1S)-1-[4-[(1S)-2- cyclopropyl-1-(4-prop-2- en...)
Affinity DataIC50: 36.9nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 497335BDBM497335(7-[[(1S)-1-[4-[(1S)-2- cyclopropyl-1-(4-prop-2- en...)
Affinity DataIC50: 36.9nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 497335BDBM497335(7-[[(1S)-1-[4-[(1S)-2- cyclopropyl-1-(4-prop-2- en...)
Affinity DataIC50: 36.9nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 600741BDBM600741(US11629156, Example 8)
Affinity DataIC50: 46nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 497348BDBM497348(US11001596, Example 6 | 1-Ethyl-7-[[(1S)-1-[4-[3- ...)
Affinity DataIC50: 46nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 497348BDBM497348(US11001596, Example 6 | 1-Ethyl-7-[[(1S)-1-[4-[3- ...)
Affinity DataIC50: 46nMAssay Description:IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280051BDBM280051(US10028961, Compound 204 | US10172864, Compound 20...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 486345BDBM486345(US10946023, Compound 151)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280052BDBM280052(US10028961, Compound 205 | US10172864, Compound 20...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279997BDBM279997(US10028961, Compound 150 | US10172864, Compound 15...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279996BDBM279996(US10028961, Compound 149 | US10172864, Compound 14...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280054BDBM280054(US10028961, Compound 207 | US10172864, Compound 20...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279995BDBM279995(US10028961, Compound 148 | US10172864, Compound 14...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280251BDBM280251(US10028961, Compound 410 | US10172864, Compound 41...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280047BDBM280047(US10028961, Compound 200 | US10172864, Compound 20...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279994BDBM279994(US10028961, Compound 147 | US10172864, Compound 14...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280048BDBM280048(US10028961, Compound 201 | US10172864, Compound 20...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280049BDBM280049(US10028961, Compound 202 | US10172864, Compound 20...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279993BDBM279993(US10028961, Compound 146 | US10172864, Compound 14...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280050BDBM280050(US10028961, Compound 203 | US10172864, Compound 20...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280006BDBM280006(US10028961, Compound 159 | US10172864, Compound 15...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280005BDBM280005(US10028961, Compound 158 | US10172864, Compound 15...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280060BDBM280060(US10028961, Compound 213 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280061BDBM280061(US10028961, Compound 214 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280003BDBM280003(US10028961, Compound 156 | US10172864, Compound 15...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280062BDBM280062(US10028961, Compound 215 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280002BDBM280002(US10028961, Compound 155 | US10172864, Compound 15...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280056BDBM280056(US10028961, Compound 209 | US10172864, Compound 20...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280001BDBM280001(US10028961, Compound 154 | US10172864, Compound 15...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280057BDBM280057(US10028961, Compound 210 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280000BDBM280000(US10028961, Compound 153 | US10172864, Compound 15...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280058BDBM280058(US10028961, Compound 211 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279999BDBM279999(US10028961, Compound 152 | US10172864, Compound 15...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280059BDBM280059(US10028961, Compound 212 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279923BDBM279923(US10028961, Compound 73 | US10172864, Compound 73 ...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280012BDBM280012(US10028961, Compound 165 | US10172864, Compound 16...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279924BDBM279924(US10028961, Compound 74 | US10172864, Compound 74 ...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280068BDBM280068(US10028961, Compound 221 | US10172864, Compound 22...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280011BDBM280011(US10028961, Compound 164 | US10172864, Compound 16...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280010BDBM280010(US10028961, Compound 163 | US10172864, Compound 16...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280063BDBM280063(US10028961, Compound 216 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280009BDBM280009(US10028961, Compound 162 | US10172864, Compound 16...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280064BDBM280064(US10028961, Compound 217 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280008BDBM280008(US10028961, Compound 161 | US10172864, Compound 16...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280065BDBM280065(US10028961, Compound 218 | US10172864, Compound 21...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280007BDBM280007(US10028961, Compound 160 | US10172864, Compound 16...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280020BDBM280020(US10028961, Compound 173 | US10172864, Compound 17...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 279960BDBM279960(US10028961, Compound 113 | US10172864, Compound 11...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme and cofactor, the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Servier Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 280019BDBM280019(US10028961, Compound 172 | US10172864, Compound 17...)
Affinity DataIC50: 50nMAssay Description:Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme, then the reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

Displayed 1 to 50 (of 1160 total ) | Next | Last >>
Jump to: