Compile Data Set for Download or QSAR
Report error Found 696 Enz. Inhib. hit(s) with Target = 'Isoform A of Ketohexokinase (Peripheral)'
TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769161BDBM769161((S)-(5-(2-((S)-3,3-difluoro-2-methylazetidin-1-yl)...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 707376BDBM707376((2S,3R)-1-{5-chloro-4-[1-(1- methyl-3-azetidinyl)-...)
Affinity DataIC50: 0.200nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 707376BDBM707376((2S,3R)-1-{5-chloro-4-[1-(1- methyl-3-azetidinyl)-...)
Affinity DataIC50: 0.200nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769159BDBM769159((S)-(5-(7,7-difluoro-2-((2S,3R)-3-fluoro-2-methyla...)
Affinity DataIC50: 0.200nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769160BDBM769160((S)-(5-(7,7-difluoro-2-((2S,3S)-3-fluoro-2-methyla...)
Affinity DataIC50: 0.300nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769137BDBM769137((S)-cyclopropyl(5-(7,7-difluoro-2-((2S,3R)-3-hydro...)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769185BDBM769185(3-[4-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769422BDBM769422((S)-(5-(7,7-difluoro-2-((R)-2-(trifluoromethyl)aze...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769140BDBM769140((S)-(2-cyclopropoxy-5-(7,7-difluoro-2-((2S,3R)-3-h...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769093BDBM769093((S)-(5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 0.700nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769400BDBM769400(3-amino-3-(4-(7,7-difluoro-2-((R)-2-(trifluorometh...)
Affinity DataIC50: 0.800nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769139BDBM769139((2-cyclopropoxy-5-(7,7-difluoro-2-((2S,3R)-3-hydro...)
Affinity DataIC50: 0.900nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 707377BDBM707377((2S,3R)-1-{5-ethyl-4-[1-(1- methyl-3-azetidinyl)-4...)
Affinity DataIC50: 0.960nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769434BDBM769434((R)-3-(4-(7,7-difluoro-2-(2-(trifluoromethyl)azeti...)
Affinity DataIC50: 1nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50628740BDBM50628740(CHEMBL5402865 | US12410160, Example 696)
Affinity DataIC50: 1nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769300BDBM769300(6-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azetidi...)
Affinity DataIC50: 1nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 768910BDBM768910((S)-1-(4-(2-(2-methylazetidin-1-yl)-6,7-dihydro-5H...)
Affinity DataIC50: 1.20nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 707370BDBM707370(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-chloro-6- (...)
Affinity DataIC50: 1.30nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 707378BDBM707378((2S,3R)-2-methyl-1-{5-methyl-4- [1-(1-methyl-3-aze...)
Affinity DataIC50: 1.30nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769184BDBM769184(3-[4-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 1.30nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 707387BDBM707387((2S,3R)-1-{6-(difluoromethyl)-5- methyl-4-[1-(1-me...)
Affinity DataIC50: 1.46nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 518444BDBM518444(US11124500, Example 35 | (2S,3R)-2-Methyl-1-[4-[1-...)
Affinity DataIC50: 1.59nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769084BDBM769084((S)-5'-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyl...)
Affinity DataIC50: 1.70nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 707370BDBM707370(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-chloro-6- (...)
Affinity DataIC50: 1.80nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 707401BDBM707401((2S,3R)-1-{4-[1-(3-azetidinyl)-4- pyrazolyl]-6-(di...)
Affinity DataIC50: 1.90nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769425BDBM769425((S)-(5-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2,3-dime...)
Affinity DataIC50: 2nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769427BDBM769427((R)-6-(7,7-difluoro-2-((R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 2nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769335BDBM769335((R)-4-amino-4-(4-(7,7-difluoro-2-(2-(trifluorometh...)
Affinity DataIC50: 2nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 707387BDBM707387((2S,3R)-1-{6-(difluoromethyl)-5- methyl-4-[1-(1-me...)
Affinity DataIC50: 2.05nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769493BDBM769493((R)-3-(5-(7,7-difluoro-2-(2-(trifluoromethyl)azeti...)
Affinity DataIC50: 2.10nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769175BDBM769175(N-((R)-6-(7,7-difluoro-2-((R)-2-(trifluoromethyl)a...)
Affinity DataIC50: 2.10nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 707391BDBM707391((2R,3R)-1-{4-[1-(1-methyl-3- azetidinyl)-4-pyrazol...)
Affinity DataIC50: 2.20nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 707367BDBM707367(2-(4-{2-[(R)-2-(trifluoromethyl)-1- azetidinyl]-5-...)
Affinity DataIC50: 2.20nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769095BDBM769095(6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 2.20nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769322BDBM769322(8-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methylazeti...)
Affinity DataIC50: 2.20nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769276BDBM769276(N-[(3R)-6-[7,7-difluoro-2-[(2S,3R)-3-fluoro-2-meth...)
Affinity DataIC50: 2.30nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 707372BDBM707372(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-ethyl-6- (t...)
Affinity DataIC50: 2.30nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769116BDBM769116((2S,3R)-1-(4-(4-((R)-3-aminotetrahydrofuran-3-yl)p...)
Affinity DataIC50: 2.30nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 768727BDBM768727((S)-4-(7,7-difluoro-2-(2-methylazetidin-1-yl)-6,7-...)
Affinity DataIC50: 2.30nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769097BDBM769097((S)-6-(7,7-difluoro-2-((2S,3R)-3-hydroxy-2-methyla...)
Affinity DataIC50: 2.40nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769280BDBM769280(3-[4-[7,7-difluoro-2-[2-(trifluoromethyl)azetidin-...)
Affinity DataIC50: 2.40nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769399BDBM769399((R)-3-amino-3-(4-(7,7-difluoro-2-(2-(trifluorometh...)
Affinity DataIC50: 2.40nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769441BDBM769441(((1,3-dioxan-5-yl)methyl)(imino)(2-methoxy-5-(2-((...)
Affinity DataIC50: 2.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769429BDBM769429((2S,3R)-1-[4-[3-(difluoromethylsulfonimidoyl)-4-me...)
Affinity DataIC50: 2.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 768893BDBM768893((S)-1-(4-(2-(2-methylazetidin-1-yl)-6,7-dihydro-5H...)
Affinity DataIC50: 2.60nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769187BDBM769187(3-[4-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 2.70nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 769284BDBM769284(3-[4-[2-[(2R)-2-(difluoromethyl)azetidin-1-yl]-7,7...)
Affinity DataIC50: 2.80nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 768800BDBM768800([4-[2-[(2S,3R)-3-fluoro-2-methyl-azetidin-1-yl]-6,...)
Affinity DataIC50: 2.90nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 707369BDBM707369(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-5-methyl-6- (...)
Affinity DataIC50: 2.90nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 768982BDBM768982(2-[2-[(2S)-2-methylazetidin-1-yl]-6,7-dihydro-5H-c...)
Affinity DataIC50: 2.90nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

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