Compile Data Set for Download or QSAR
Report error Found 927 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 3'
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154708BDBM154708(US8999957, Table 2, Compound 45)
Affinity DataKd:  0.0100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154710BDBM154710(US8999957, Table 2, Compound 47)
Affinity DataKd:  0.0200nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154709BDBM154709(US8999957, Table 2, Compound 46)
Affinity DataKd:  0.0300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154670BDBM154670(US8999957, Table 2, Compound 7)
Affinity DataKd:  0.0520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154713BDBM154713(US8999957, Table 2, Compound 50)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154698BDBM154698(US8999957, Table 2, Compound 35)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154699BDBM154699(US8999957, Table 2, Compound 36)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331095BDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of ERK1 phosphorylation in VEGF-stimulated serum-starved human HUVEC cells by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154694BDBM154694(US8999957, Table 2, Compound 31)
Affinity DataKd:  0.130nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154680BDBM154680(US8999957, Table 2, Compound 17)
Affinity DataKd:  0.150nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154692BDBM154692(US8999957, Table 2, Compound 29)
Affinity DataKd:  0.200nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154681BDBM154681(US8999957, Table 2, Compound 18)
Affinity DataKd:  0.210nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154696BDBM154696(US8999957, Table 2, Compound 33)
Affinity DataKd:  0.210nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154673BDBM154673(US8999957, Table 2, Compound 10)
Affinity DataKd:  0.220nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154687BDBM154687(US8999957, Table 2, Compound 24)
Affinity DataKd:  0.240nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154720BDBM154720(US8999957, Table 2, Compound 59)
Affinity DataKd:  0.260nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154682BDBM154682(US8999957, Table 2, Compound 19)
Affinity DataKd:  0.270nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154706BDBM154706(US8999957, Table 2, Compound 43)
Affinity DataKd:  0.280nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154599BDBM154599(US8999957, Column 153, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154634BDBM154634(US8999957, Table 1, Compound 2)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50094465BDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataKi: <0.300nMAssay Description:Binding affinity to ERK1 (unknown origin) measured after 20 mins in presence of [gamma33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154599BDBM154599(US8999957, Column 153, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154711BDBM154711(US8999957, Table 2, Compound 48)
Affinity DataKd:  0.390nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154665BDBM154665(US8999957, Table 2, Compound 2)
Affinity DataKd:  0.400nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154666BDBM154666(US8999957, Table 2, Compound 3)
Affinity DataKd:  0.400nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154712BDBM154712(US8999957, Table 2, Compound 49)
Affinity DataKd:  0.420nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154675BDBM154675(US8999957, Table 2, Compound 12)
Affinity DataKd:  0.480nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154667BDBM154667(US8999957, Table 2, Compound 4)
Affinity DataKd:  0.5nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154674BDBM154674(US8999957, Table 2, Compound 11)
Affinity DataKd:  0.510nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154669BDBM154669(US8999957, Table 2, Compound 6)
Affinity DataKd:  0.520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154691BDBM154691(US8999957, Table 2, Compound 28)
Affinity DataKd:  0.530nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325534BDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.550nMAssay Description:Inhibition of ERK1 phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154588BDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154588BDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154600BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154600BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154635BDBM154635(US8999957, Table 1, Compound 3)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154700BDBM154700(US8999957, Table 2, Compound 37)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154591BDBM154591(US8999957, Column 141, Compound 7 | US8999957, Tab...)
Affinity DataKd:  0.610nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154591BDBM154591(US8999957, Column 141, Compound 7 | US8999957, Tab...)
Affinity DataKd:  0.610nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601918BDBM50601918(TEMUTERKIB | Temuterkib | Ly 3214996 | Ly3214996 |...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity to ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154676BDBM154676(US8999957, Table 2, Compound 13)
Affinity DataKd:  0.660nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154596BDBM154596(US8999957, Column 152, Compound 1)
Affinity DataKd:  0.800nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154664BDBM154664(US8999957, Table 2, Compound 1)
Affinity DataKd:  0.810nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154688BDBM154688(US8999957, Table 2, Compound 25)
Affinity DataKd:  0.830nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154685BDBM154685(US8999957, Table 2, Compound 22)
Affinity DataKd:  0.900nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154719BDBM154719(US8999957, Table 2, Compound 57)
Affinity DataKd:  0.970nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 120095BDBM120095(US8697715, 39 | US9259470, 39 | US10525036, Exampl...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 154589BDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)
Affinity DataKd:  1.20nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 696313BDBM696313(US20240300975, Compound WX001)
Affinity DataIC50: 1.20nMAssay Description:1. Purpose of the Assay:The ability of compounds to inhibit ERK1 and ERK2 kinase activity was measured.2. Assay Buffer:20 mM Hepes (pH 7.5), 10 mM Mg...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

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