Report error Found 858 Enz. Inhib. hit(s) with Target = 'Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase'
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP1 in cell based assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand InfoPDB
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
China Innovation Center of Roche
Curated by ChEMBL
China Innovation Center of Roche
Curated by ChEMBL
Ligand Info







3D Structure (crystal)



























