Compile Data Set for Download or QSAR
Report error Found 2625 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 1'
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 86211BDBM86211(NSC_40539 | CAS_52809-07-1 | Quisqualate)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224406BDBM50224406(9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyri...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345941BDBM50345941(9-(2-Methyl-allylamino)-3-p-tolyl-3H-pyrido[3',2':...)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224407BDBM50224407(2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyr...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163592BDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301822BDBM50301822(CHEMBL568443 | CHEMBL1645349 | 5-(1-(2-fluoropyrid...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50301822BDBM50301822(CHEMBL568443 | CHEMBL1645349 | 5-(1-(2-fluoropyrid...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364722BDBM50364722(CHEMBL1951661)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224391BDBM50224391(9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5''...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50224402BDBM50224402(8-(4-chlorophenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50002371BDBM50002371(Glutaminsaeure | glutamic acid | Glutamate | CHEMB...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50364723BDBM50364723(CHEMBL1951662)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345942BDBM50345942(3-(4-Methoxy-phenyl)-9-(2-methyl-allylamino)-3H-py...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224392BDBM50224392(9-(4-chlorophenyl)-2,3-dihydro-2(S)-methyl-1H-pyri...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224395BDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163592BDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50: 0.550nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163592BDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50: 0.550nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163613BDBM50163613((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Affinity DataIC50: 0.560nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224400BDBM50224400(2,3-dihydro-3(R)-methyl-9-(4-methylphenyl)-1H-pyri...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345947BDBM50345947(3-(4-Chloro-phenyl)-9-prop-2-ynylamino-3H-pyrido[3...)
Affinity DataKi:  0.600nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345950BDBM50345950(3-(4-Bromo-phenyl)-9-prop-2-ynylamino-3H-pyrido[3'...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345934BDBM50345934(9-Allylamino-3-(4-bromo-phenyl)-3H-pyrido[3',2':4,...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50224390BDBM50224390(8-(4-methylphenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364700BDBM50364700(CHEMBL1951872)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50171313BDBM50171313((3-Ethyl-2-methyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataKi:  0.870nMAssay Description:In vitro affinity for cloned rat metabotropic glutamate 1 receptors stably expressed on CHO cells determined using [3H]-R214127 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50333368BDBM50333368([11C]-cis-(3-ethyl-2-methylquinolin-6-yl)(4-methox...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50333368BDBM50333368([11C]-cis-(3-ethyl-2-methylquinolin-6-yl)(4-methox...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345947BDBM50345947(3-(4-Chloro-phenyl)-9-prop-2-ynylamino-3H-pyrido[3...)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50379862BDBM50379862(CHEMBL2011870)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163596BDBM50163596((2-Amino-3-ethyl-quinolin-6-yl)-(4-methoxy-cyclohe...)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401714BDBM50401714(CHEMBL2205923)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401688BDBM50401688(CHEMBL2205921)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50177100BDBM50177100(9-dimethylamino-3-cycoheptyl-3H-5-thia-1,3,6-triaz...)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50401715BDBM50401715(CHEMBL2205922)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50177080BDBM50177080(3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at rat mGluR1 expressed in 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50177063BDBM50177063(9-dimethylamino-3-(p-bromophenyl)-3H-5-thia-1,3,6-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50224405BDBM50224405(2,3-dihydro-9-(4-methoxyphenyl)-1H-pyrimido[4'',5'...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177100BDBM50177100(9-dimethylamino-3-cycoheptyl-3H-5-thia-1,3,6-triaz...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345931BDBM50345931(9-Allylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':...)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345933BDBM50345933(9-Allylamino-3-(4-chloro-phenyl)-3H-pyrido[3',2':4...)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345937BDBM50345937(9-(Allyl-methyl-amino)-3-(4-chloro-phenyl)-3H-pyri...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50089896BDBM50089896(CHEMBL315591 | LY367385 | 4-(Amino-carboxy-methyl)...)
Affinity DataKi:  1.18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345940BDBM50345940(3-(4-Chloro-phenyl)-9-(2-methyl-allylamino)-3H-pyr...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163592BDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50: 1.21nMAssay Description:Antagonist activity at human mGlu1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50163606BDBM50163606(CHEMBL369459 | R 214127 | 1-(3,4-Dihydro-2H-1-oxa-...)
Affinity DataKi:  1.35nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50231744BDBM50231744(NPS 2390 | CHEMBL399160 | quinoxaline-2-carboxylic...)
Affinity DataKi:  1.36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50224406BDBM50224406(9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyri...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Mouse)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50333367BDBM50333367(6-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to mouse mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50345948BDBM50345948(9-Prop-2-ynylamino-3-p-tolyl-3H-pyrido[3',2':4,5]t...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50345943BDBM50345943(3-(4-Bromo-phenyl)-9-(2-methyl-allylamino)-3H-pyri...)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
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