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Report error Found 1345 Enz. Inhib. hit(s) with Target = 'Methionine aminopeptidase 2'
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36590(FOS-72)
Affinity DataEC50:  0.0130nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36589(Ovalicin)
Affinity DataEC50:  0.0180nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36588(AGM-1470)
Affinity DataEC50:  0.0370nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
LigandPNGBDBM17428(N-[5-(benzylsulfanyl)-4H-1,2,4-triazol-3-yl]pyridi...)
Affinity DataKi:  0.0400nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17355(5-(benzylsulfanyl)-N-(2-methylphenyl)-4H-1,2,4-tri...)
Affinity DataKi:  0.0400nM ΔG°:  -58.8kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17388(5-(benzylsulfanyl)-N-(4-methoxyphenyl)-4H-1,2,4-tr...)
Affinity DataKi:  0.0500nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17365(5-(benzylsulfanyl)-N-(4-methylphenyl)-4H-1,2,4-tri...)
Affinity DataKi:  0.0700nM ΔG°:  -57.4kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM36597(FOS-69)
Affinity DataIC50: 0.100nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36592(FOS-70)
Affinity DataEC50:  0.120nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
LigandPNGBDBM17390(5-{[(2-fluorophenyl)methyl]sulfanyl}-N-(4-methoxyp...)
Affinity DataKi:  0.130nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17362(5-[(3-methylbut-2-en-1-yl)sulfanyl]-N-(2-methylphe...)
Affinity DataKi:  0.150nM ΔG°:  -55.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17395(N-(4-methoxyphenyl)-5-[(3-methylbut-2-en-1-yl)sulf...)
Affinity DataKi:  0.160nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataKi:  0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataKi:  0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM17358(5-{[(2-fluorophenyl)methyl]sulfanyl}-N-(2-methylph...)
Affinity DataKi:  0.230nM ΔG°:  -54.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17430(N-(5-{[(2-fluorophenyl)methyl]sulfanyl}-4H-1,2,4-t...)
Affinity DataKi:  0.300nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36597(FOS-69)
Affinity DataEC50:  0.310nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
LigandPNGBDBM50137405(Carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2...)
Affinity DataIC50: 0.390nMAssay Description:Inhibitory activity against Methionine aminopeptidase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
LigandPNGBDBM36589(Ovalicin)
Affinity DataIC50: 0.400nMpH: 7.35 T: 2°CAssay Description:Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
LigandPNGBDBM50295172(4-Hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methy...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of methionine aminopeptidase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandPNGBDBM17411(methyl 4-[(5-{[(2-fluorophenyl)methyl]sulfanyl}-4H...)
Affinity DataKi:  0.410nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17377(5-(benzylsulfanyl)-N-(4-chlorophenyl)-4H-1,2,4-tri...)
Affinity DataKi:  0.430nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM50137403(Acetyl-carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(R...)
Affinity DataIC50: 0.430nMAssay Description:Inhibitory activity against Methionine aminopeptidase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM36595(FOS-68)
Affinity DataEC50:  0.460nMpH: 7.5Assay Description:Proliferation assay using bovine aortic endothelial cell (BAEC) line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2011
Entry Details Article
PubMed
LigandPNGBDBM17431(N-(5-{[(3,4-difluorophenyl)methyl]sulfanyl}-4H-1,2...)
Affinity DataKi:  0.5nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17416(methyl 4-({5-[(3-methylbut-2-en-1-yl)sulfanyl]-4H-...)
Affinity DataKi:  0.5nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17352(5-(benzylsulfanyl)-N-phenyl-4H-1,2,4-triazol-3-ami...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM50137404(Acetic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-m...)
Affinity DataIC50: 0.510nMAssay Description:Inhibitory activity against Methionine aminopeptidase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
LigandPNGBDBM17385(N-(4-chlorophenyl)-5-[(3-methylbut-2-en-1-yl)sulfa...)
Affinity DataKi:  0.520nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17380(N-(4-chlorophenyl)-5-{[(2-fluorophenyl)methyl]sulf...)
Affinity DataKi:  0.610nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM50113436(fumagillin | CHEMBL32838)
Affinity DataIC50: 0.630nMAssay Description:Inhibitory activity against Methionine aminopeptidase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
LigandPNGBDBM17368(5-{[(2-fluorophenyl)methyl]sulfanyl}-N-(4-methylph...)
Affinity DataKi:  0.650nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17408(methyl 4-{[5-(benzylsulfanyl)-4H-1,2,4-triazol-3-y...)
Affinity DataKi:  0.700nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17354(N-phenyl-5-[(thiophen-2-ylmethyl)sulfanyl]-4H-1,2,...)
Affinity DataKi:  0.75nM ΔG°:  -51.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM50137402(4-Ethyl-piperazine-1-carboxylic acid (3R,4S,5S,6R)...)
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against Methionine aminopeptidase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
LigandPNGBDBM17418(methyl 4-[(5-{[(5-methyl-1,2-oxazol-3-yl)methyl]su...)
Affinity DataKi:  0.800nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM401307(US10005756, Compound A78)
Affinity DataKd:  0.880nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM401307(US10005756, Compound A78)
Affinity DataKd:  0.880nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM17413(methyl 4-({5-[(pyridin-2-ylmethyl)sulfanyl]-4H-1,2...)
Affinity DataKi:  0.900nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17414(methyl 4-({5-[(pyridin-4-ylmethyl)sulfanyl]-4H-1,2...)
Affinity DataKi:  0.900nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM401307(US10005756, Compound A78)
Affinity DataKi:  0.900nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM401307(US10005756, Compound A78)
Affinity DataKi:  0.900nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM17405(N-(3,4-dimethoxyphenyl)-5-[(3-methylbut-2-en-1-yl)...)
Affinity DataKi:  0.900nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM50512383(CHEMBL137766)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50131562(Deca-2,4,6,8-tetraenedioic acid mono-{5-methoxy-4-...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against purified recombinant human Methionine Aminopeptidase 2 (MetAP2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM17442(5-[(3-methylbut-2-en-1-yl)sulfanyl]-N-phenyl-4H-1,...)
Affinity DataKi:  1nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM17461(5-(4-iodophenyl)-1H-1,2,3-triazole | 1,2,3-triazol...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50: 1nMAssay Description:Inhibition of methionine aminopeptidase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataKi:  1nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed
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