Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with Target = 'Methylcytosine dioxygenase TET1'
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639624BDBM50639624(CHEMBL5565375)
Affinity DataIC50: 250nMAssay Description:Inhibition of N-terminal 3xFlag-tagged recombinant human TET1 catalytic domain (E1418 to V2136 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639623BDBM50639623(CHEMBL5527999)
Affinity DataIC50: 250nMAssay Description:Inhibition of N-terminal 3xFlag-tagged recombinant human TET1 catalytic domain (E1418 to V2136 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50639622BDBM50639622(CHEMBL5557372)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal 3xFlag-tagged recombinant human TET1 catalytic domain (E1418 to V2136 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50498665BDBM50498665(CHEMBL1982368)
Affinity DataEC50:  440nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50570893BDBM50570893(CHEMBL4851104)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human N-terminal Flag-tagged TET1 (1418 to 2136 residues) expressed in Baculovirus infected Sf9 cells assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50570891BDBM50570891(CHEMBL4872206)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of TET1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29589BDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594525BDBM50594525(CHEMBL5189434)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396018BDBM50396018(CHEMBL1230640)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594530BDBM50594530(CHEMBL5181110)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594527BDBM50594527(CHEMBL5177921)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594520BDBM50594520(CHEMBL5194845)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 26106BDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50483927BDBM50483927(CHEMBL3183531)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118338BDBM118338(US8653111, 62)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396018BDBM50396018(CHEMBL1230640)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of FLAG-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in doxycycline induced human U2OS cells incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594529BDBM50594529(CHEMBL5201158)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50510129BDBM50510129(CHEMBL4475458)
Affinity DataEC50:  2.40E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594528BDBM50594528(CHEMBL5178563)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50508775BDBM50508775(CHEMBL4457636)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of TET1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50508775BDBM50508775(CHEMBL4457636)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged TET1 (1418 to 2136 residues) expressed in baculovirus infected sf9 cells assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118338BDBM118338(US8653111, 62)
Affinity DataEC50:  7.90E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594523BDBM50594523(CHEMBL5182454)
Affinity DataIC50: 8.10E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293660BDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60875BDBM60875(GSK-J1 | 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 223320BDBM223320(KDOAM-25)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 195608BDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594531BDBM50594531(CHEMBL5198555)
Affinity DataIC50: 1.07E+5nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50620916BDBM50620916(CHEMBL92309 | N-Methoxycarbonylmethyl-Oxalamic Aci...)
Affinity DataEC50:  1.10E+5nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 26122BDBM26122(FUMARIC ACID | Fumarate | (2E)-but-2-enedioic acid...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 26121BDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594521BDBM50594521(CHEMBL5193964)
Affinity DataIC50: 1.66E+5nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50361471BDBM50361471(CHEMBL1614745)
Affinity DataKi:  2.46E+5nMAssay Description:Competitive inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344962BDBM50344962((2S)-2-HYDROXYPENTANEDIOIC ACID | L-2-Hydroxygluta...)
Affinity DataKi:  2.69E+5nMAssay Description:Competitive inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50504654BDBM50504654(CHEBI:76004 | AZL 0 211089 | AZL O 211089 | AZL-02...)
Affinity DataEC50:  3.16E+5nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Mus musculus)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50361471BDBM50361471(CHEMBL1614745)
Affinity DataIC50: 4.00E+6nMAssay Description:Inhibition of recombinant mouse TET1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed