Compile Data Set for Download or QSAR
Report error Found 717 Enz. Inhib. hit(s) with Target = 'Microtubule-associated protein tau'
TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281656BDBM281656(US10022461, Compound 126)
Affinity DataKi:  0.180nM ΔG°:  -55.6kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281558BDBM281558(US10022461, Compound 9)
Affinity DataKi:  0.220nM ΔG°:  -55.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281645BDBM281645(US10022461, Compound 115)
Affinity DataKi:  0.224nM ΔG°:  -55.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281560BDBM281560(US10022461, Compound 12)
Affinity DataKi:  0.290nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281561BDBM281561(US10022461, Compound 13)
Affinity DataKi:  0.290nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281633BDBM281633(US10022461, Compound 103)
Affinity DataKi:  0.320nM ΔG°:  -54.2kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281609BDBM281609(US10022461, Compound 59)
Affinity DataKi:  0.330nM ΔG°:  -54.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281563BDBM281563(US10022461, Compound 14-1)
Affinity DataKi:  0.330nM ΔG°:  -54.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281635BDBM281635(US10022461, Compound 105)
Affinity DataKi:  0.383nM ΔG°:  -53.7kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281559BDBM281559(US10022461, Compound 11-5)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50610396BDBM50610396(CHEMBL5278104)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of tau phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281565BDBM281565(US10022461, Compound 16)
Affinity DataKi:  0.410nM ΔG°:  -53.6kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281639BDBM281639(US10022461, Compound 109)
Affinity DataKi:  0.423nM ΔG°:  -53.5kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281566BDBM281566(US10022461, Compound 17)
Affinity DataKi:  0.430nM ΔG°:  -53.5kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281567BDBM281567(US10022461, Compound 18 | US20240165276, Compound ...)
Affinity DataKi:  0.430nM ΔG°:  -53.5kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281649BDBM281649(US10022461, Compound 119)
Affinity DataKi:  0.438nM ΔG°:  -53.4kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50615173BDBM50615173(CHEMBL5265782)
Affinity DataKi:  0.460nMAssay Description:Displacement of [11C]PBB3 in human brain tau incubated for 30 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50384537BDBM50384537(CHEMBL2036430)
Affinity DataKi:  0.480nMAssay Description:Displacement of Thioflavin S from recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281557BDBM281557(US10022461, Compound 8)
Affinity DataKi:  0.480nM ΔG°:  -53.2kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281623BDBM281623(US10022461, Compound 75)
Affinity DataKi:  0.480nM ΔG°:  -53.2kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281644BDBM281644(US10022461, Compound 114)
Affinity DataKi:  0.494nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281651BDBM281651(US10022461, Compound 121)
Affinity DataKi:  0.512nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281626BDBM281626(US10022461, Compound 93)
Affinity DataKi:  0.530nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281564BDBM281564(US10022461, Compound 15)
Affinity DataKi:  0.530nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281555BDBM281555(US10022461, Compound 6)
Affinity DataKi:  0.540nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281630BDBM281630(US10022461, Compound 99)
Affinity DataKi:  0.550nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281568BDBM281568(US10022461, Compound 19)
Affinity DataKi:  0.620nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281599BDBM281599(US10022461, Compound 49)
Affinity DataKi:  0.670nM ΔG°:  -52.4kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281642BDBM281642(US10022461, Compound 112)
Affinity DataKi:  0.672nM ΔG°:  -52.4kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281638BDBM281638(US10022461, Compound 108)
Affinity DataKi:  0.677nM ΔG°:  -52.3kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281624BDBM281624(US10022461, Compound 88)
Affinity DataKi:  0.690nM ΔG°:  -52.3kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50400616BDBM50400616(CHEMBL2203439)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to heparin induced human Tau 441 at 50 pM to 500 nM after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281569BDBM281569(US10022461, Compound 20)
Affinity DataKi:  0.75nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281600BDBM281600(US10022461, Compound 50)
Affinity DataKi:  0.75nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281622BDBM281622(US10022461, Compound 72)
Affinity DataKi:  0.760nM ΔG°:  -52.0kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281643BDBM281643(US10022461, Compound 113)
Affinity DataKi:  0.784nM ΔG°:  -52.0kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281601BDBM281601(US10022461, Compound 51)
Affinity DataKi:  0.870nM ΔG°:  -51.7kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281628BDBM281628(US10022461, Compound 95)
Affinity DataKi:  0.960nM ΔG°:  -51.5kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281602BDBM281602(US10022461, Compound 52)
Affinity DataKi:  0.980nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 674316BDBM674316(US20240165276, Compound 6)
Affinity DataIC50: 1nMAssay Description:In the presence of 3 nM of the known tau ligand [3H]-THK5117 (Novandi Chemistry) and 0.2 mM 0N4R tau fibrils in binding buffer (50 mM Tris-HCl, pH 7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50020865BDBM50020865(CHEMBL3286988)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human microtubule associated protein tau aggregation by Thiazin-red R displacement fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281603BDBM281603(US10022461, Compound 53)
Affinity DataKi:  1.02nM ΔG°:  -51.3kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281604BDBM281604(US10022461, Compound 54)
Affinity DataKi:  1.05nM ΔG°:  -51.2kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281631BDBM281631(US10022461, Compound 100)
Affinity DataKi:  1.06nM ΔG°:  -51.2kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281654BDBM281654(US10022461, Compound 124)
Affinity DataKi:  1.07nM ΔG°:  -51.2kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281641BDBM281641(US10022461, Compound 111)
Affinity DataKi:  1.09nM ΔG°:  -51.2kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281597BDBM281597(US10022461, Compound 44)
Affinity DataKi:  1.13nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281629BDBM281629(US10022461, Compound 98)
Affinity DataKi:  1.13nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281605BDBM281605(US10022461, Compound 55)
Affinity DataKi:  1.14nM ΔG°:  -51.0kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 281632BDBM281632(US10022461, Compound 101)
Affinity DataKi:  1.14nM ΔG°:  -51.0kJ/molepH: 7.4 T: 2°CAssay Description:For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

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