Compile Data Set for Download or QSAR
Report error Found 758 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 7'
LigandChemical structure of BindingDB Monomer ID 692247BDBM692247(US20240279233, Example 47 | (E)-N-isopropyl-N,11-d...)
Affinity DataIC50: 1nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692203BDBM692203(US20240279233, Example 3)
Affinity DataIC50: 1nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692247BDBM692247(US20240279233, Example 47 | (E)-N-isopropyl-N,11-d...)
Affinity DataIC50: 1nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692213BDBM692213(US20240279233, Example 13)
Affinity DataIC50: 1nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692209BDBM692209(US20240279233, Example 9)
Affinity DataIC50: 1nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692212BDBM692212(US20240279233, Example 12)
Affinity DataIC50: 1nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692211BDBM692211(US20240279233, Example 11)
Affinity DataIC50: 1nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  1.5nMAssay Description:Binding constant for TAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50209760BDBM50209760(CHEMBL3885421)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of TAK1 (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50209760BDBM50209760(CHEMBL3885421)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 692234BDBM692234(US20240279233, Example 34)
Affinity DataIC50: 2nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692246BDBM692246(US20240279233, Example 46)
Affinity DataIC50: 2nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692300BDBM692300(US20240279233, Example 100)
Affinity DataIC50: 2nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50557619BDBM50557619(CHEMBL4796239)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human full-length His-tagged TAK1-TAB1 fusion protein (437 to 504 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 692269BDBM692269(US20240279233, Example 69)
Affinity DataIC50: 2nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692225BDBM692225(US20240279233, Example 25)
Affinity DataIC50: 2nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186972BDBM50186972(CHEMBL3823127)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50209759BDBM50209759(CHEMBL3884839)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50209759BDBM50209759(CHEMBL3884839)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of TAK1 (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  2.90nMAssay Description:Binding constant for TAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to TAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 692249BDBM692249(US20240279233, Example 50 | (E)-17-(3-methoxy-3-me...)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692249BDBM692249(US20240279233, Example 50 | (E)-17-(3-methoxy-3-me...)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692303BDBM692303(US20240279233, Example 103)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692216BDBM692216(US20240279233, Example 16)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50187106BDBM50187106(CHEMBL3823992)
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 692257BDBM692257(US20240279233, Example 57)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692232BDBM692232(US20240279233, Example 32 | (E)-N,N,11-trimethyl-3...)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692316BDBM692316(US20240279233, Example 116)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692202BDBM692202(US20240279233, Example 5 | US20240279233, Example ...)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692264BDBM692264(US20240279233, Example 64)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692285BDBM692285(US20240279233, Example 85 | (R,E)-11-methyl-17-(1-...)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692231BDBM692231(US20240279233, Example 31 | (E)-N,N,11-trimethyl-3...)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692240BDBM692240(US20240279233, Example 40)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692241BDBM692241(US20240279233, Example 41)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692266BDBM692266(US20240279233, Example 66)
Affinity DataIC50: 3nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 254948BDBM254948(US9505765, 38)
Affinity DataIC50: 3.10nMAssay Description:TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50209653BDBM50209653(CHEMBL3884616)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50209653BDBM50209653(CHEMBL3884616)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of TAK1 (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50209662BDBM50209662(CHEMBL3884569)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50209662BDBM50209662(CHEMBL3884569)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of TAK1 (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Ambit Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186971BDBM50186971(CHEMBL3823882)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 692326BDBM692326(US20240279233, Example 126 | (11S,E)-14-(3-fluoro-...)
Affinity DataIC50: 4nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692217BDBM692217(US20240279233, Example 17)
Affinity DataIC50: 4nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692304BDBM692304(US20240279233, Example 104)
Affinity DataIC50: 4nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692243BDBM692243(US20240279233, Example 43)
Affinity DataIC50: 4nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692297BDBM692297(US20240279233, Example 97)
Affinity DataIC50: 4nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692245BDBM692245(US20240279233, Example 45)
Affinity DataIC50: 4nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 692299BDBM692299(US20240279233, Example 99)
Affinity DataIC50: 4nMAssay Description:Assay kits from Promega Corporation V4089 were used according to manufacturer's instructions and adapted as outlined here. ADP-Glo Kinase Assay k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50438224BDBM50438224(CHEMBL2407759)
Affinity DataIC50: 4nMAssay Description:Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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