Compile Data Set for Download or QSAR
Report error Found 80 Enz. Inhib. hit(s) with Target = 'Mu-type opioid receptor [N127C]'
TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579538BDBM579538(US11484525, Compound BD-131LR)
Affinity DataKi:  4.10nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579486BDBM579486(US11484525, Compound Naloxone)
Affinity DataKi:  4.10nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579537BDBM579537(US11484525, Compound DD-34L-ANTAGONIST)
Affinity DataKi:  6.20nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579527BDBM579527(US11484525, Compound DD-57L)
Affinity DataKi:  7.70nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579522BDBM579522(US11484525, Compound DD-63L-LB-S)
Affinity DataKi:  8.30nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579539BDBM579539(US11484525, Compound BD-131LS)
Affinity DataKi:  12nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579520BDBM579520(US11484525, Compound DD-63L-RS | US11484525, Compo...)
Affinity DataKi:  14nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579543BDBM579543(US11484525, Compound DD-144-ANTAGONIST-Covalent)
Affinity DataKi:  18nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579557BDBM579557(US11484525, Compound DD198)
Affinity DataKi:  22nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579533BDBM579533(US11484525, Compound DD-46L)
Affinity DataKi:  25nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 21015BDBM21015([tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephali...)
Affinity DataKi:  25nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 50493818BDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  27nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579562BDBM579562(US11484525, Compound DDLM-15)
Affinity DataKi:  27nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579503BDBM579503(US11484525, Compound DD-81)
Affinity DataKi:  29nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579532BDBM579532(US11484525, Compound DD-47LS)
Affinity DataKi:  34nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579561BDBM579561(US11484525, Compound DDLM-10)
Affinity DataKi:  36nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 50518036BDBM50518036(CHEMBL4467777 | US11484525, Compound BD-122LS-PZM2...)
Affinity DataKi:  37nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579528BDBM579528(US11484525, Compound DD-32D | US11484525, Compound...)
Affinity DataKi:  38nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579523BDBM579523(US11484525, Compound DD-53-LS)
Affinity DataKi:  38nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579515BDBM579515(US11484525, Compound DD-88B-S)
Affinity DataKi:  41nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579510BDBM579510(US11484525, Compound BD-122DR | US11484525, Compou...)
Affinity DataKi:  42nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579519BDBM579519(US11484525, Compound DD-61L-B-S)
Affinity DataKi:  42nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579501BDBM579501(US11484525, Compound DD-15 | US11484525, Compound ...)
Affinity DataKi:  43nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579560BDBM579560(US11484525, Compound DDLM-08)
Affinity DataKi:  43nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579520BDBM579520(US11484525, Compound DD-63L-RS | US11484525, Compo...)
Affinity DataKi:  43nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579530BDBM579530(US11484525, Compound DD-33D | US11484525, Compound...)
Affinity DataKi:  46nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579553BDBM579553(US11484525, Compound DD185)
Affinity DataKi:  47nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579516BDBM579516(US11484525, Compound DD-90)
Affinity DataKi:  47nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579485BDBM579485(US11484525, Compound Morphine)
Affinity DataKi:  52nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579536BDBM579536(US11484525, Compound DD-131)
Affinity DataKi:  66nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579517BDBM579517(US11484525, Compound DD-91)
Affinity DataKi:  72nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579518BDBM579518(US11484525, Compound DD-61L-A-R)
Affinity DataKi:  81nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579555BDBM579555(US11484525, Compound DD196)
Affinity DataKi:  81nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579525BDBM579525(US11484525, Compound DD-50-LS-)
Affinity DataKi:  85nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579545BDBM579545(US11484525, Compound DD-179)
Affinity DataKi:  90nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579513BDBM579513(US11484525, Compound DD-88A-R)
Affinity DataKi:  96nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579558BDBM579558(US11484525, Compound DD200)
Affinity DataKi:  110nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579492BDBM579492(US11484525, Compound BD-127-DS | US11484525, Compo...)
Affinity DataKi:  140nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579524BDBM579524(US11484525, Compound DD-51-LS)
Affinity DataKi:  150nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579504BDBM579504(US11484525, Compound DD-77)
Affinity DataKi:  170nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579497BDBM579497(US11484525, Compound DD-35D | US11484525, Compound...)
Affinity DataKi:  180nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579548BDBM579548(US11484525, Compound DD-154)
Affinity DataKi:  200nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579534BDBM579534(US11484525, Compound DD-79-I)
Affinity DataKi:  210nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579497BDBM579497(US11484525, Compound DD-35D | US11484525, Compound...)
Affinity DataKi:  210nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579556BDBM579556(US11484525, Compound DD187)
Affinity DataKi:  220nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579540BDBM579540(US11484525, Compound DD-120-D1-covalent-compound)
Affinity DataKi:  240nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579508BDBM579508(US11484525, Compound DD-181)
Affinity DataKi:  290nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579510BDBM579510(US11484525, Compound BD-122DR | US11484525, Compou...)
Affinity DataKi:  290nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579528BDBM579528(US11484525, Compound DD-32D | US11484525, Compound...)
Affinity DataKi:  310nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMu-type opioid receptor [N127C](Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 579506BDBM579506(US11484525, Compound DD-102)
Affinity DataKi:  320nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

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