Compile Data Set for Download or QSAR
Report error Found 411 Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit'
TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446463(US10669271, Example 16 | US10669271, Example 19 | ...)
Affinity DataEC50: <10nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446453(US10669271, Example 6 | US10669271, Example 33 | (...)
Affinity DataEC50: <10nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446481(US10669271, Example 34 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50: <10nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446478(US10669271, Example 31 | (S)-1-((7-cyano-2-(3̸...)
Affinity DataEC50: <10nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446473(US10669271, Example 26 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50: <10nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446477(US10669271, Example 30 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50: <10nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446470(US10669271, Example 23 | (S)-1-((7-cyano-2-(3̸...)
Affinity DataEC50: <10nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527568(US11186588, Example 26)
Affinity DataIC50: 12.3nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527554(US11186588, Example 9)
Affinity DataIC50: 17.6nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527550(US11186588, Example 5)
Affinity DataIC50: 27.5nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM511480(US11059789, Example 40 | US11691950, Example 40)
Affinity DataIC50: 28nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527563(US11186588, Example 22 | US11186588, Example 21)
Affinity DataIC50: 30.3nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527557(US11186588, Example 12)
Affinity DataIC50: 32.1nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527563(US11186588, Example 22 | US11186588, Example 21)
Affinity DataIC50: 33.6nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527616(US11186588, Example 92)
Affinity DataIC50: 34.2nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM511481(US11059789, Example 25 | US11691950, Example 25)
Affinity DataIC50: 39nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527608(US11186588, Example 81)
Affinity DataIC50: 47.2nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM50062648(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50: 50nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527567(US11186588, Example 25)
Affinity DataIC50: 50.3nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM527549(US11186588, Example 3)
Affinity DataIC50: 51.9nMAssay Description:A549/NF-κB-luc cells (available from Panomics, Cat No. LR0051) were prepared at 375,000 cells/mL in the culture medium. The 375,000 cells/mL A54...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446465(US10669271, Example 18 | US10669271, Example 21 | ...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446469(US10669271, Example 22 | (S)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446464(US10669271, Example 17 | US10669271, Example 20 | ...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM511483(US11059789, Example 66 | US11691950, Example 66)
Affinity DataIC50: 55nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446463(US10669271, Example 16 | US10669271, Example 19 | ...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446464(US10669271, Example 17 | US10669271, Example 20 | ...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446465(US10669271, Example 18 | US10669271, Example 21 | ...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446452(US10669271, Example 5 | (S)-1-((7-cyano-2-(3′...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446453(US10669271, Example 6 | US10669271, Example 33 | (...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446476(US10669271, Example 29 | (R)-1-((2-(3′-(2-am...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446451(US10669271, Example 4 | (S)-1-((7-cyano-2-(3′...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446474(US10669271, Example 27 | (R)-3-(1-((7-cyano-2-(3&#...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446475(US10669271, Example 28 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446472(US10669271, Example 25 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446450(US10669271, Example 3 | (S)-1-((7-cyano-2-(3′...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446448(US10669271, Example 1 | (R)-1-((7-cyano-2-(3′...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446449(US10669271, Example 2 | (R)-1-((7-cyano-2-(3′...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM511482(US11059789, Example 83 | US11691950, Example 83)
Affinity DataIC50: 55nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446471(US10669271, Example 24 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446458(US10669271, Example 11 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446456(US10669271, Example 9 | (R)-1-((7-cyano-2-(3′...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446457(US10669271, Example 10 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446455(US10669271, Example 8 | (R)-1-((7-cyano-2-(3′...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446479(US10669271, Example 32 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446454(US10669271, Example 7 | (R)-1-((7-cyano-2-(3′...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446462(US10669271, Example 15 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446460(US10669271, Example 13 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446461(US10669271, Example 14 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM446459(US10669271, Example 12 | (R)-1-((7-cyano-2-(3̸...)
Affinity DataEC50:  55nMAssay Description:PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Incyte

US Patent
LigandPNGBDBM50196926(Rocaglamide | CHEMBL438139 | US10085988, Compound ...)
Affinity DataIC50: 75nMAssay Description:Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
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