Compile Data Set for Download or QSAR
Report error Found 2015 Enz. Inhib. hit(s) with Target = 'Oxysterols receptor LXR-alpha'
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551946BDBM50551946(CHEMBL4764328)
Affinity DataEC50:  0.0800nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 19993BDBM19993(CHEMBL62136 | [3H]T0901317 | T 0901317 | N-[4-(1,1...)
Affinity DataEC50:  0.0980nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551956BDBM50551956(CHEMBL4756418)
Affinity DataEC50:  0.145nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551964BDBM50551964(CHEMBL4745005)
Affinity DataEC50:  0.161nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551953BDBM50551953(CHEMBL4764838)
Affinity DataEC50:  0.174nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551945BDBM50551945(CHEMBL4747448)
Affinity DataEC50:  0.214nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551951BDBM50551951(CHEMBL4749385)
Affinity DataEC50:  0.251nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551949BDBM50551949(CHEMBL4762546)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551947BDBM50551947(CHEMBL4797369)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551950BDBM50551950(CHEMBL4757761)
Affinity DataEC50:  0.274nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551948BDBM50551948(CHEMBL4760781)
Affinity DataEC50:  0.277nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551957BDBM50551957(CHEMBL4755317)
Affinity DataEC50:  0.372nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 19992BDBM19992(2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]meth...)
Affinity DataEC50:  0.401nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 26066BDBM26066(JMC517161 Compound 12 | 2-[(2-chloro-4-fluoropheny...)
Affinity DataEC50:  0.431nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551954BDBM50551954(CHEMBL4757158)
Affinity DataEC50:  0.708nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306072BDBM50306072(2-isobutyl-1-(3-(3-(methylsulfonyl)phenoxy)phenyl)...)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50378590BDBM50378590(CHEMBL611735)
Affinity DataIC50: 0.810nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551961BDBM50551961(CHEMBL4791199)
Affinity DataEC50:  0.843nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305075BDBM50305075(3-benzyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50: 0.920nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551944BDBM50551944(CHEMBL4748480)
Affinity DataEC50:  0.928nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551955BDBM50551955(CHEMBL4777240)
Affinity DataEC50:  0.940nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50167697BDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataEC50:  1nMAssay Description:Effective concentration in recombinant human LXRalpha ligand binding domain in homogeneous time-resolved fluorescence assay More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305077BDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305077BDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50167697BDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241903BDBM50241903(acetyl Podocarpic acid anhydride | CHEMBL506838)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human recombinant LXRalpha expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRalpha ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50167697BDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration in LXRSPA alpha binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306070BDBM50306070(2-isopropyl-1-(3-(3-(methylsulfonyl)phenoxy)phenyl...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50167698BDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataEC50:  1nMAssay Description:Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50167698BDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataEC50:  1nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305077BDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50192109BDBM50192109(2-(4-(benzyl(2,2,2-trifluoroethyl)amino)-3-chlorop...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to LXRalpha by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50167697BDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataEC50:  1nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50198769BDBM50198769(CHEBI:72761 | TRYPROSTATIN A)
Affinity DataKd:  1nMAssay Description:Binding affinity to full length human LXRalpha assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551958BDBM50551958(CHEMBL4780872)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305072BDBM50305072(8-chloro-3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306073BDBM50306073(1-(3-(3-(methylsulfonyl)phenoxy)phenyl)-2-phenyl-4...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305073BDBM50305073(3-benzyl-8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306074BDBM50306074(2-(4-fluorobenzyl)-1-(3-(3-(methylsulfonyl)phenoxy...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551963BDBM50551963(CHEMBL4764539)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306068BDBM50306068(1-(3-(3-(methylsulfonyl)phenoxy)phenyl)-2,4-bis(tr...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305064BDBM50305064(3-(3-(3-(3-methyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306075BDBM50306075(4-chloro-2-isopropyl-1-(3-(3-(methylsulfonyl)pheno...)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305070BDBM50305070(4-(3-(3-(ethylsulfonyl)phenoxy)phenyl)-3-methyl-8-...)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306069BDBM50306069(2-ethyl-1-(3-(3-(methylsulfonyl)phenoxy)phenyl)-4-...)
Affinity DataIC50: 1.70nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551952BDBM50551952(CHEMBL4762542)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305068BDBM50305068(4-(3-(3-(isopropylsulfonyl)phenoxy)phenyl)-3-methy...)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305060BDBM50305060(4-(3-(3-fluoro-5-(methylsulfonyl)phenoxy)phenyl)-3...)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305077BDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/Retinoic acid receptor RXR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551959BDBM50551959(CHEMBL4759393)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
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