Compile Data Set for Download or QSAR
Report error Found 97 Enz. Inhib. hit(s) with Target = 'Polyphenol oxidase 1'
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195552BDBM195552(4-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl...)
Affinity DataIC50: 36nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 240726BDBM240726(US9422261, Compound 4)
Affinity DataIC50: 80nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 240723BDBM240723(US9422261, Compound 1)
Affinity DataIC50: 90nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 240731BDBM240731(US9422261, 4-(1- phenylethyl) benzene-1,3- diol)
Affinity DataIC50: 100nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 240725BDBM240725(US9422261, Compound 3)
Affinity DataIC50: 200nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473792BDBM473792(1-(3-methyl-2,4-dimethoxyphenyl)-3-(2′,4R...)
Affinity DataIC50: 240nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195551BDBM195551(4-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl...)
Affinity DataIC50: 255nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 233016BDBM233016(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Affinity DataKi:  290nM ΔG°:  -37.6kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 240724BDBM240724(US9422261, Compound 2)
Affinity DataIC50: 400nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195553BDBM195553(4-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl...)
Affinity DataIC50: 473nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473767BDBM473767(1-(2,4-dihydroxyphenyl)-3-(3',4'-dihydroxyphenyl)-...)
Affinity DataIC50: 500nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 233016BDBM233016(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Affinity DataKi:  640nM ΔG°:  -35.6kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195547BDBM195547(2-((2-Nitrobenzylidene)amino)-5-mercapto-1,3,4-thi...)
Affinity DataIC50: 671nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473769BDBM473769(1-(2,4-dihydroxyphenyl)-3-(2'-hydroxyphenyl)-1-pro...)
Affinity DataIC50: 700nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195548BDBM195548(2-((2-Methoxybenzylidene)amino)-5-mercapto-1,3,4-t...)
Affinity DataIC50: 733nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195540BDBM195540(2-((2-Fluorobenzylidene)amino)-5-mercapto-1,3,4-th...)
Affinity DataIC50: 765nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195550BDBM195550(2-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl...)
Affinity DataIC50: 785nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473768BDBM473768(1-(2,4-dihydroxyphenyl)-3-(3',4'-dimethoxyphenyl)-...)
Affinity DataIC50: 850nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195554BDBM195554(2-((2,4,6-Trimethoxybenzylidene)amino)-5-mercapto-...)
Affinity DataIC50: 907nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 233016BDBM233016(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Affinity DataKi:  950nM ΔG°:  -35.8kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 50248158BDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 1.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 233016BDBM233016(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Affinity DataKi:  1.05E+3nM ΔG°:  -35.5kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 233168BDBM233168(N-(2-Hydroxy-ethyl)-3,5-dinitro-benzamide (7))
Affinity DataIC50: 1.09E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195546BDBM195546(2-((4-(Tert-butyl)benzylidene)amino)-5-mercapto-1,...)
Affinity DataIC50: 1.39E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 234394BDBM234394(Polyhydroxy benzophenone, 10)
Affinity DataIC50: 1.40E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 240727BDBM240727(US9422261, Compound 5)
Affinity DataIC50: 1.50E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195544BDBM195544(4-Chloro-2-(((5-mercapto-1,3,4-thiadiazol-2-yl)imi...)
Affinity DataIC50: 1.72E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195545BDBM195545(4-Bromo-2-(((5-mercapto-1,3,4-thiadiazol-2-yl)imin...)
Affinity DataIC50: 1.97E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 240729BDBM240729(US9422261, Unigen resorcinol derivative | US968291...)
Affinity DataIC50: 2.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 233170BDBM233170(N-Hydroxy-4,N-dimethyl-benzamide (9))
Affinity DataIC50: 2.09E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195542BDBM195542(2-((4-Chlorobenzylidene)amino)-5-mercapto-1,3,4-th...)
Affinity DataIC50: 2.46E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473770BDBM473770(1-(2,4-dihydroxyphenyl)-3-(2'-methoxyphenyl)-1-pro...)
Affinity DataIC50: 3.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 233169BDBM233169(N-(2-Bromo-ethyl)-3,5-dinitro-benzamide (8))
Affinity DataIC50: 3.08E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195543BDBM195543(2-((3,4-Dichlorobenzylidene)amino)-5-mercapto-1,3,...)
Affinity DataIC50: 3.62E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 50198715BDBM50198715(CHEMBL245416 | L-mimosine | (2S)-2-amino-3-(3-hydr...)
Affinity DataIC50: 3.68E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L](White button mushroom)
University of Technology Sydney

LigandChemical structure of BindingDB Monomer ID 173587BDBM173587((2E)-3-(3,5-dihydroxyphenyl)-1-(3-hydroxynaphthale...)
Affinity DataKi:  3.80E+3nM IC50: 1.04E+4nMpH: 6.8Assay Description:The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L](White button mushroom)
University of Technology Sydney

LigandChemical structure of BindingDB Monomer ID 173584BDBM173584((2E)-3-(2,4-dihydroxyphenyl)-1-(3-hydroxynaphthale...)
Affinity DataKi:  4.50E+3nM IC50: 1.44E+4nMpH: 6.8Assay Description:The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195541BDBM195541(2-((3-Chlorobenzylidene)amino)-5-mercapto-1,3,4-th...)
Affinity DataIC50: 4.75E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 240730BDBM240730(US9422261, Unigen resorcinol derivative | US968291...)
Affinity DataIC50: 4.90E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandChemical structure of BindingDB Monomer ID 195549BDBM195549(2-((3,5-Dimethoxybenzylidene)amino)-5-mercapto-1,3...)
Affinity DataIC50: 5.35E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 50382706BDBM50382706(CHEMBL2023168 | Benzyldithiocarbamate sodium salt ...)
Affinity DataKi:  5.70E+3nM ΔG°:  -31.1kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 50382706BDBM50382706(CHEMBL2023168 | Benzyldithiocarbamate sodium salt ...)
Affinity DataKi:  5.90E+3nM ΔG°:  -31.0kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473771BDBM473771(1-(2,4-dihydroxyphenyl)-3-(4'-methoxyphenyl)-1-pro...)
Affinity DataIC50: 6.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 234393BDBM234393(Polyhydroxy benzophenone, 9)
Affinity DataIC50: 6.40E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 50249353BDBM50249353(1,1,3-trihydroxybenzophenone | 2,2',4-trihydroxybe...)
Affinity DataIC50: 7.30E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473773BDBM473773(1-(2,4-dihydroxyphenyl)-3-phenyl-1-propanol | US10...)
Affinity DataIC50: 8.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473772BDBM473772(1-(2,4,6-trihydroxyphenyl)-3-(4'-aminophenyl)-1-pr...)
Affinity DataIC50: 8.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 473774BDBM473774(1-(2,4-dihydroxyphenyl)-3-(3'-methoxy-4'-hydroxyph...)
Affinity DataIC50: 8.50E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 234397BDBM234397(Polyhydroxy benzophenone, 15)
Affinity DataIC50: 8.80E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandChemical structure of BindingDB Monomer ID 50382706BDBM50382706(CHEMBL2023168 | Benzyldithiocarbamate sodium salt ...)
Affinity DataKi:  9.40E+3nM ΔG°:  -28.9kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
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