Compile Data Set for Download or QSAR
Report error Found 76 Enz. Inhib. hit(s) with Target = 'Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1'
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419064BDBM50419064(CHEMBL1823874)
Affinity DataIC50: 15.8nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419067BDBM50419067(CHEMBL1823878)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419065BDBM50419065(CHEMBL1823875)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419068BDBM50419068(CHEMBL1823879)
Affinity DataIC50: 50.1nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419069BDBM50419069(CHEMBL1823880)
Affinity DataIC50: 79.4nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419080BDBM50419080(CHEMBL1823677)
Affinity DataIC50: 126nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419053BDBM50419053(ZD-7288 | CHEMBL2052019)
Affinity DataIC50: 158nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419070BDBM50419070(CHEMBL1823881)
Affinity DataIC50: 200nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419066BDBM50419066(CHEMBL1823876)
Affinity DataIC50: 251nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419085BDBM50419085(CHEMBL1823887)
Affinity DataIC50: 316nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688533BDBM688533(US20240190854, Example 9)
Affinity DataIC50: 370nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419055BDBM50419055(CHEMBL1823666)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419074BDBM50419074(CHEMBL1823886)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419062BDBM50419062(CHEMBL1435630)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419083BDBM50419083(CHEMBL1823882)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688629BDBM688629(US20240190854, Example 125)
Affinity DataIC50: 400nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688578BDBM688578(US20240190854, Example 73)
Affinity DataIC50: 500nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Mouse)
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326990BDBM50326990(3,3'-((2Z,2'Z)-4,4'-((R)-2-(3,4-dimethoxyphenyl)pr...)
Affinity DataEC50:  600nMAssay Description:Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419075BDBM50419075(CHEMBL1823888)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419078BDBM50419078(CHEMBL1823667)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419060BDBM50419060(CHEMBL1823674)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688577BDBM688577(US20240190854, Example 72)
Affinity DataIC50: 1.00E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419054BDBM50419054(CHEMBL1823665)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688574BDBM688574(US20240190854, Example 69)
Affinity DataIC50: 1.40E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419084BDBM50419084(CHEMBL1823885)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688530BDBM688530(US20240190854, Example 6)
Affinity DataIC50: 1.80E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688568BDBM688568(US20240190854, Example 68 | US20240190854, Example...)
Affinity DataIC50: 2.00E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688582BDBM688582(US20240190854, Example 77)
Affinity DataIC50: 2.20E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Mouse)
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326991BDBM50326991(3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)
Affinity DataEC50:  2.31E+3nMAssay Description:Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688634BDBM688634(US20240190854, Example 14)
Affinity DataIC50: 2.40E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419076BDBM50419076(CHEMBL1823889)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688632BDBM688632(US20240190854, Example 12)
Affinity DataIC50: 2.80E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688529BDBM688529(US20240190854, Example 5)
Affinity DataIC50: 2.90E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688639BDBM688639(US20240190854, Example 19)
Affinity DataIC50: 2.90E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688636BDBM688636(US20240190854, Example 16)
Affinity DataIC50: 3.00E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688535BDBM688535(US20240190854, Example 30)
Affinity DataIC50: 3.00E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688633BDBM688633(US20240190854, Example 13)
Affinity DataIC50: 3.20E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688620BDBM688620(US20240190854, Example 116)
Affinity DataIC50: 3.40E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688575BDBM688575(US20240190854, Example 70)
Affinity DataIC50: 3.80E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688644BDBM688644(US20240190854, Example 24)
Affinity DataIC50: 4.20E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688576BDBM688576(US20240190854, Example 71)
Affinity DataIC50: 4.40E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688618BDBM688618(US20240190854, Example 114)
Affinity DataIC50: 4.50E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Mouse)
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326992BDBM50326992(ivabradine | CHEMBL471737)
Affinity DataEC50:  4.50E+3nMAssay Description:Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688579BDBM688579(US20240190854, Example 74)
Affinity DataIC50: 4.60E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688635BDBM688635(US20240190854, Example 15)
Affinity DataIC50: 5.10E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688641BDBM688641(US20240190854, Example 21)
Affinity DataIC50: 5.30E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Mouse)
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326993BDBM50326993(3-((Z)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)
Affinity DataEC50:  5.60E+3nMAssay Description:Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688638BDBM688638(US20240190854, Example 18)
Affinity DataIC50: 7.60E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688568BDBM688568(US20240190854, Example 68 | US20240190854, Example...)
Affinity DataIC50: 8.00E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688529BDBM688529(US20240190854, Example 5)
Affinity DataIC50: 8.70E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

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