Compile Data Set for Download or QSAR
Report error Found 18643 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2'
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM494073(US10988481, Compound 6)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells with holding potential of -80 mV by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50117930(N-(4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidi...)
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells with holding potential of -80 mV by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50616086(CHEMBL5432371)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells with holding potential of -80 mV by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327248(endo-3-(8-(4-methylbenzyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327247(endo-3-(8-(3-phenylpropyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327244(3-Endo-(8-((5-methylthiophen-2-yl)methyl)-8-azabic...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095768(CHEMBL3590463)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327246(endo-3-(8-phenethyl-8-azabicyclo[3.2.1]octan-3-ylo...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50214370(N-(4-{2-[[2-(4-methanesulfonylaminophenoxy)ethyl](...)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50082445(CHEMBL3422978)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM89440(4-(4-chlorophenyl)butyl-diethyl-heptylazanium;4-me...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50321777((R)-1'-benzyl-6-methoxy-1-phenyl-1,6-dihydrospiro[...)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327243(endo-3-(8-(thiophen-2-ylmethyl)-8-azabicyclo[3.2.1...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095768(CHEMBL3590463)
Affinity DataKd:  0.440nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM396904(US9981950, Example 113B)
Affinity DataIC50: 0.480nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM396904(US9981950, Example 113B)
Affinity DataIC50: 0.480nMAssay Description:Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM398608(US10323021, Example 114)
Affinity DataIC50: 0.510nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM396905(US9981950, Example 114)
Affinity DataIC50: 0.510nMAssay Description:Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM396901(US9981950, Example 110)
Affinity DataIC50: 0.520nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327249(endo-3-(8-(3-methylbenzyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM396901(US9981950, Example 110)
Affinity DataIC50: 0.520nMAssay Description:Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50319962((1S,4S)-2-(5-(benzo[b]thiophen-5-yl)pyridin-2-yl)-...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50319955((1S,4S)-2-(5-(benzo[b]thiophen-5-yl)pyrimidin-2-yl...)
Affinity DataKi:  0.560nMAssay Description:Displacement of [3H]dofetidile from human ERG by whole-cell patch clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50325855(exo-3-((1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327256(endo-3-(8-(benzo[d][1,3]dioxol-5-ylmethyl)-8-azabi...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327250(endo-3-(8-(2-methylbenzyl)-8-azabicyclo[3.2.1]octa...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM396903(US9981950, Example 113A)
Affinity DataIC50: 0.650nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50375351(CHEMBL259732)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM396903(US9981950, Example 113A)
Affinity DataIC50: 0.650nMAssay Description:Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50333594(4-(Naphthalen-2-ylmethoxy)-1-{4-[2-(pyrrolidin-1-y...)
Affinity DataIC50: 0.670nMAssay Description:Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM300972(5-((6S,8R)-1- fluoro-8- methyl-7- (2,2,2- trifluor...)
Affinity DataIC50: 0.690nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327264(endo-3-(8-(2-oxo-2-(phenylamino)ethyl)-8-azabicycl...)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50082380(CHEMBL3422952)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50314264((-)-(R)-2-(1-(2-(2-(azetidin-1-yl)ethyl)benzo[b]th...)
Affinity DataKi:  0.730nMAssay Description:Inhibition of human ERG expressed in HEK cells assessed as blockade of potassium tail current by standard patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095652(CHEMBL3590452)
Affinity DataKd:  0.730nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50391763(CHEMBL2146867)
Affinity DataIC50: 0.760nMAssay Description:Displacement of [35S]MK499 from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM300961(1-(3-Fluoropropyl)-N-(4-((6R,8R)-8-methyl-7-(2,2,2...)
Affinity DataIC50: 0.810nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50333604(1-(4-{2-[Benzyl(methyl)amino]ethoxy}phenyl)-4-(ben...)
Affinity DataIC50: 0.810nMAssay Description:Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50082429(CHEMBL3422970)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM436275(US10590130, Example 61 | 2,2-difluoro-3- ((6S,8R)-...)
Affinity DataIC50: 0.880nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50082385(CHEMBL3422959)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM24226(cid_2247 | [3H]-ASTEMIZOLE | Hismanal | ASTEMIZOLE...)
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity against Potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM24226(cid_2247 | [3H]-ASTEMIZOLE | Hismanal | ASTEMIZOLE...)
Affinity DataIC50: 0.900nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM24226(cid_2247 | [3H]-ASTEMIZOLE | Hismanal | ASTEMIZOLE...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of hERG potassium channel in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM24226(cid_2247 | [3H]-ASTEMIZOLE | Hismanal | ASTEMIZOLE...)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM24226(cid_2247 | [3H]-ASTEMIZOLE | Hismanal | ASTEMIZOLE...)
Affinity DataIC50: 0.912nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM300973(2-fluoro-6- ((6S,8R)-1- fluoro-8- methyl-7- (2,2,2...)
Affinity DataIC50: 0.940nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50279579(CHEMBL4171244)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50327268(endo-3-(8-(1,2,3,4-tetrahydronaphthalen-1-yl)-8-az...)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50082440(CHEMBL3422977)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of MK499 binding to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
Displayed 1 to 50 (of 18643 total ) | Next | Last >>
Jump to: