Compile Data Set for Download or QSAR
Report error Found 664 Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 1'
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 588052BDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PRMT1 using Histone H4 and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590375BDBM50590375(CHEMBL5187396)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PRMT1 using Histone H4 and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Rat)
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243294BDBM50243294(CHEMBL4094513)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of rat His-tagged PRMT1 (11 to 353 residues) expressed in Escherichia coli BL21(DE3) incubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636218BDBM50636218(CHEMBL5559689)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PRMT1 (unknown origin) using SAM and histone (1 to 21 residues) as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648689BDBM50648689(CHEMBL5612531)
Affinity DataIC50: 3nMAssay Description:Inhibition of PRMT1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636218BDBM50636218(CHEMBL5559689)
Affinity DataIC50: 3nMAssay Description:Inhibition of PRMT1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636218BDBM50636218(CHEMBL5559689)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636218BDBM50636218(CHEMBL5559689)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50095432BDBM50095432(CHEMBL3589026)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636202BDBM50636202(CHEMBL5527874)
Affinity DataIC50: 4nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636201BDBM50636201(CHEMBL5517922)
Affinity DataIC50: 4nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178103BDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PRMT1 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178103BDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PRMT1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 178103BDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human PRMT1 assessed as inhibition of methylation activity using biotin-labeled peptide as substrate and [3H]-SAM by scintillation prox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50095354BDBM50095354(CHEMBL3589030)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50095356BDBM50095356(CHEMBL3589028)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636206BDBM50636206(CHEMBL5565736)
Affinity DataIC50: 5nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50095353BDBM50095353(CHEMBL3589031)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651366BDBM50651366(CHEMBL5633975)
Affinity DataIC50: 5nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Rat)
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243294BDBM50243294(CHEMBL4094513)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of rat His-tagged PRMT1 (11 to 353 residues) expressed in Escherichia coli BL21(DE3) using biotinylated H4 peptide (1 to 21 residues) as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637545BDBM50637545(CHEMBL5532081)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Rat)
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243295BDBM50243295(CHEMBL4084293)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat His-tagged PRMT1 (11 to 353 residues) expressed in Escherichia coli BL21(DE3) using biotinylated H4 peptide (1 to 21 residues) as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50095357BDBM50095357(CHEMBL3589027)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50095355BDBM50095355(CHEMBL3589029)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50095348BDBM50095348(CHEMBL3589036)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636200BDBM50636200(CHEMBL5542306)
Affinity DataIC50: 9nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636204BDBM50636204(CHEMBL5532462)
Affinity DataIC50: 9nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643941BDBM50643941(CHEMBL5567635)
Affinity DataIC50: 10nMAssay Description:Inhibition of PRMT1 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636218BDBM50636218(CHEMBL5559689)
Affinity DataIC50: 10nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 178103BDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKi:  11nM IC50: 30nMAssay Description:In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643940BDBM50643940(CHEMBL5566241)
Affinity DataIC50: 11nMAssay Description:Inhibition of PRMT1 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50095433BDBM50095433(CHEMBL3589913)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50095351BDBM50095351(CHEMBL3589033)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636212BDBM50636212(CHEMBL5560201)
Affinity DataIC50: 14nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50095347BDBM50095347(CHEMBL3589037)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50095352BDBM50095352(CHEMBL3589032)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636210BDBM50636210(CHEMBL5557453)
Affinity DataIC50: 15nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50095442BDBM50095442(CHEMBL3589038)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636203BDBM50636203(CHEMBL5561358)
Affinity DataIC50: 16nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636205BDBM50636205(CHEMBL5558900)
Affinity DataIC50: 16nMAssay Description:Inhibition of PRMT1 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648951BDBM50648951(CHEMBL5613785)
Affinity DataIC50: 16nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648690BDBM50648690(CHEMBL5613916)
Affinity DataIC50: 17nMAssay Description:Inhibition of PRMT1 (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50095434BDBM50095434(CHEMBL3589912)
Affinity DataIC50: 18nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 502122BDBM502122(US11028083, Example 91)
Affinity DataIC50: 22nMAssay Description:This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 502138BDBM502138(US11028083, Example 100b)
Affinity DataIC50: 22nMAssay Description:This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 502103BDBM502103(US11028083, Example 80b | US11028083, Example 79b)
Affinity DataIC50: 24nMAssay Description:This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 502116BDBM502116(US11028083, Example 87b)
Affinity DataIC50: 24nMAssay Description:This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50095438BDBM50095438(CHEMBL3589042)
Affinity DataIC50: 26nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Daiichi Sankyo Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 502127BDBM502127(US11028083, Example 94b)
Affinity DataIC50: 27nMAssay Description:This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50095350BDBM50095350(CHEMBL3589034)
Affinity DataIC50: 27nMAssay Description:Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
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