Compile Data Set for Download or QSAR
Report error Found 2039 Enz. Inhib. hit(s) with Target = 'Protein cereblon'
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586185BDBM50586185(CHEMBL5090416)
Affinity DataIC50: 0.0200nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586179BDBM50586179(CHEMBL4744617)
Affinity DataIC50: 0.310nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586184BDBM50586184(CHEMBL5078429)
Affinity DataIC50: 0.450nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630767BDBM50630767(CHEMBL5279477)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of CRBN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643720BDBM50643720(CHEMBL5574408)
Affinity DataIC50: 0.900nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594639BDBM594639(Methyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 693802BDBM693802(3-(5-(((1S,2S)-2-(3-((cis)-4- isopropoxycyclohexyl...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 562168BDBM562168(US11401256, Example 60 | 6-(3,4-Dihydro-2H-quinoli...)
Affinity DataKd:  1nMAssay Description:Process 1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content 2) Titrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594669BDBM594669(2-Benzoyl-2,7-diazaspiro[4.5]decane-6,8-dione | US...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 693805BDBM693805(3-(5-(((1S,2S)-2-(3-(4- ethoxycyclohexyl)azetidin-...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594668BDBM594668(2-(1-Acetylindoline-4-carbonyl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594700BDBM594700(8-(Pyrazolo[1,5-a]pyridine-3-carbonyl)-1,3,8-triaz...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594643BDBM594643((+)-2-(4-Nitrophenyl)-2,7-diazaspiro[4.5]decane-6,...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594705BDBM594705(8-(4-Nitrophenyl)-1,3,8-triazaspiro[4.5]decane-2,4...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594640BDBM594640(2-(Thiazolo[4,5-b]pyridin-2-yl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594672BDBM594672(2-(5-Aminopyridin-2-yl-2,7-diazaspiro[4.5]decane-6...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594678BDBM594678(2-(Pyrazolo[1,5-a]pyridine-3-carbonyl)-2,7-diazasp...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594645BDBM594645(2-(Benzo[d]thiazol-2-yl)-2,7-diazaspiro[4.5]decane...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594708BDBM594708(8-Benzoyl-2,8-diazaspiro[4.5]decane-1,3-dione | US...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 693807BDBM693807(3-(5-(((1S,2S)-2-(3-(4- (difluoromethoxy)cyclohexy...)
Affinity DataEC50:  1nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594663BDBM594663(2-(5-Nitropyridin-2-yl)-2,7-diazaspiro[4.5]decane-...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594662BDBM594662(2-(Benzo[d]thiazole-5-carbonyl)-2,7-diazaspiro[4.5...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594699BDBM594699(8-(Benzofuran-3-carbonyl)-1,3,8-triazaspiro[4.5]de...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594666BDBM594666(2-(5-Nitro-1H-benzo[d]imidazol-2-yl)-2,7-diazaspir...)
Affinity DataKd: <1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594665BDBM594665(Methyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)...)
Affinity DataKd:  1nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586180BDBM50586180(CHEMBL5082689)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630767BDBM50630767(CHEMBL5279477)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of N-terminal fused Nano Luc CRBN in HEK293T cells by NanoBRET CRBN engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630767BDBM50630767(CHEMBL5279477)
Affinity DataIC50: 1.10nMAssay Description:Displacement of BODIPY-lenalidomide from human N-terminal NanoLuc-fused CRBN expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643726BDBM50643726(CHEMBL5566094)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643725BDBM50643725(CHEMBL5575548)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643724BDBM50643724(CHEMBL5565362)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643721BDBM50643721(CHEMBL5575700)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein cereblon/CUL4A/AR(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50634837BDBM50634837(CHEMBL5437141)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to human androgen receptor transfected in HEK293 cell membrane co-transfected with ARC1 assessed as inhibition of [3H]-methyltrienol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586176BDBM50586176(CHEMBL4742130)
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643722BDBM50643722(CHEMBL5564627)
Affinity DataIC50: 1.80nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 693802BDBM693802(3-(5-(((1S,2S)-2-(3-((cis)-4- isopropoxycyclohexyl...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594704BDBM594704(8-(Benzo[d]thiazol-2-yl)-2,8-diazaspiro[4.5]decane...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505628BDBM50505628(CHEMBL4449512)
Affinity DataIC50: 2nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 669519BDBM669519(US20240132463, Compound 1 | N-(2-(2,6-dioxopiperid...)
Affinity DataIC50: 2nMAssay Description:In this competitive fluorescent polarization assay Cy5 conjugated lenalidomide analog (Cy5-O-Len)13 was used as a fluorescent probe. 6×His-CRBN-DDB1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 686544BDBM686544(US20240246935, Example 124 | 3-(5-(((1S,2S)-2-(3-(...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 693789BDBM693789(3-(5-(((1S,2S)-2-(3-(4,4- difluorocyclohexyl)azeti...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594658BDBM594658(US11584748, Example 25 | US11584748, Example 56 | ...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594657BDBM594657(tert-Butyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594658BDBM594658(US11584748, Example 25 | US11584748, Example 56 | ...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594694BDBM594694(8-(Benzo[d]thiazol-2-yl)-1,3,8-triazaspiro[4.5]dec...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 594693BDBM594693(8-Benzoyl-1,3,8-triazaspiro[4.5]decane-2,4-dione |...)
Affinity DataKd:  2nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 562157BDBM562157(US11401256, Example 49 | N-Methyl-2-[3-(methylcarb...)
Affinity DataKd:  2nMAssay Description:Process 1) Optimization of measurement parameters to minimize protein consumption and to minimize the dilution effect and the DMSO content 2) Titrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 693795BDBM693795(US20240287037, Example 9 | US20240287037, Example ...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 693793BDBM693793(US20240287037, Example 7 | 3-(5-(((1S,2S)-2-(3-((c...)
Affinity DataEC50:  2nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetProtein cereblon(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643723BDBM50643723(CHEMBL5575710)
Affinity DataIC50: 2.80nMAssay Description:Binding affinity to GST-tagged human CRBN by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
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