Compile Data Set for Download or QSAR
Report error Found 3209 Enz. Inhib. hit(s) with Target = 'Protein mono-ADP-ribosyltransferase TIPARP'
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700589BDBM700589(US20240336629, Compound 90B)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of PARP7 (unknown origin) incubated for 1 hr by chemiluminescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50634478BDBM50634478(CHEMBL5400567)
Affinity DataIC50: 0.110nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50634483BDBM50634483(CHEMBL5397180)
Affinity DataIC50: 0.140nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629205BDBM50629205(CHEMBL5394931)
Affinity DataIC50: 0.141nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629210BDBM50629210(CHEMBL5413717)
Affinity DataIC50: 0.151nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629209BDBM50629209(CHEMBL5415829)
Affinity DataIC50: 0.179nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50634482BDBM50634482(CHEMBL5393845)
Affinity DataIC50: 0.179nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50634481BDBM50634481(CHEMBL5422715)
Affinity DataIC50: 0.185nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50634479BDBM50634479(CHEMBL5407242)
Affinity DataIC50: 0.188nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50634480BDBM50634480(CHEMBL5421106)
Affinity DataIC50: 0.188nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by incubation with probe for 1.5 hrs by MSD e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701363BDBM701363((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.190nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630273BDBM50630273(CHEMBL5403305)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged PARP7 (400 to 657(end) residues) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629206BDBM50629206(CHEMBL5419793)
Affinity DataIC50: 0.212nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 431646BDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataKd:  0.220nMAssay Description:Binding affinity to PARP7 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 431795BDBM431795(US10550105, Example 661)
Affinity DataKd:  0.220nMAssay Description:Binding affinity to PARP7 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629211BDBM50629211(CHEMBL5422627)
Affinity DataIC50: 0.232nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629208BDBM50629208(CHEMBL5409582)
Affinity DataIC50: 0.233nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701389BDBM701389(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.240nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629204BDBM50629204(CHEMBL5425262)
Affinity DataIC50: 0.263nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629202BDBM50629202(CHEMBL5409458)
Affinity DataIC50: 0.288nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701379BDBM701379(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.380nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701312BDBM701312((R)-(1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyrid...)
Affinity DataIC50: 0.380nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701399BDBM701399(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.390nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700540BDBM700540(US20240336629, Compound 67A)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PARP7 (unknown origin) incubated for 1 hr by chemiluminescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50643508BDBM50643508(CHEMBL5568973)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PARP7 (unknown origin) incubated for 1 hr by chemiluminescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50629203BDBM50629203(CHEMBL5417113)
Affinity DataIC50: 0.405nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700584BDBM700584(US20240336629, Compound 88A)
Affinity DataIC50: 0.416nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700467BDBM700467(US20240336629, Compound 21A)
Affinity DataIC50: 0.424nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701309BDBM701309(N-(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin...)
Affinity DataIC50: 0.440nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700585BDBM700585(US20240336629, Compound 88B)
Affinity DataIC50: 0.446nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701376BDBM701376(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.460nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701394BDBM701394(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.480nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701397BDBM701397(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.490nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700590BDBM700590(US20240336629, Compound 91)
Affinity DataIC50: 0.496nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701359BDBM701359((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.5nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701356BDBM701356((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.520nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701325BDBM701325((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.520nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701384BDBM701384(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.530nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701374BDBM701374(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.530nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701311BDBM701311(US20240351997, Example 35)
Affinity DataIC50: 0.530nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701391BDBM701391(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridin-3-...)
Affinity DataIC50: 0.540nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701370BDBM701370((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.560nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700586BDBM700586(US20240336629, Compound 89A)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of PARP7 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701357BDBM701357((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.560nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595876BDBM50595876(CHEMBL5209116 | US20240336629, Compound 2)
Affinity DataIC50: 0.584nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595876BDBM50595876(CHEMBL5209116 | US20240336629, Compound 2)
Affinity DataIC50: 0.584nMAssay Description:Inhibition of PARP7 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701425BDBM701425((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.590nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700588BDBM700588(US20240336629, Compound 90A)
Affinity DataIC50: 0.592nMAssay Description:(1) Each compound to be tested was prepared using gradient dilution method with DMSO and water to obtain a solution with the concentration of 50 nM, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701303BDBM701303(US20240351997, Example 26)
Affinity DataIC50: 0.600nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 701358BDBM701358((S)-1-(6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridi...)
Affinity DataIC50: 0.600nMAssay Description:1. Preparation of 384-well histone-coated plate: 25 μL of histone solution was added to each well, and the plate was incubated overnight at 4° C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

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