Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with Target = 'RAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase'
LigandChemical structure of BindingDB Monomer ID 431867BDBM431867(US10550114, Compound 1a)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182517BDBM182517(US9145392, 218)
Affinity DataIC50: 1nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50550738BDBM50550738(CHEMBL4792262)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50572156BDBM50572156(CHEMBL4853207)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50550740BDBM50550740(CHEMBL4780030)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182373BDBM182373(US9145392, 74)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182529BDBM182529(US9145392, 230)
Affinity DataIC50: 4nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182519BDBM182519(US9145392, 220)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182390BDBM182390(US9145392, 91)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50593633BDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182413BDBM182413(US9145392, 114)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182307BDBM182307(US9145392, 8)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50572155BDBM50572155(CHEMBL4876889)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50550739BDBM50550739(CHEMBL4788683)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182372BDBM182372(US9145392, 73)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182381BDBM182381(US9145392, 82)
Affinity DataIC50: 12nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182377BDBM182377(US9145392, 78)
Affinity DataIC50: 16nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50528415BDBM50528415(CHEMBL4457064)
Affinity DataIC50: 21nMAssay Description:Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182518BDBM182518(US9145392, 219)
Affinity DataIC50: 23nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50528416BDBM50528416(CHEMBL4440965)
Affinity DataIC50: 44nMAssay Description:Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182337BDBM182337(US9145392, 38)
Affinity DataIC50: 84nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182356BDBM182356(US9145392, 57)
Affinity DataIC50: 140nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50188913BDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  160nMAssay Description:Activity against AKT-mediated PRAS40 T246P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182367BDBM182367(US9145392, 68)
Affinity DataIC50: 230nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182306BDBM182306(US9145392, 7)
Affinity DataIC50: 260nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50188913BDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  320nMAssay Description:Activity against AKT-mediated GSK3 S9P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 224325BDBM224325(US9321760, 2 | US10080750, Compound 2 | US9662330,...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182361BDBM182361(US9145392, 62)
Affinity DataIC50: 350nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50188913BDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  370nMAssay Description:Activity against AKT-mediated S6RP S235/236P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182308BDBM182308(US9145392, 9)
Affinity DataIC50: 518nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182354BDBM182354(US9145392, 55)
Affinity DataIC50: 850nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182347BDBM182347(US9145392, 48)
Affinity DataIC50: 880nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182338BDBM182338(US9145392, 39)
Affinity DataIC50: 930nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 224329BDBM224329(US9321760, 6 | US10080750, Compound 6 | US9662330,...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 224481BDBM224481(US9321760, 159 | US10080750, Compound 159 | US9662...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 28123BDBM28123(CHEMBL318804 | 4-({3-chloro-4-[(1-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 224477BDBM224477(US9321760, 155 | US10080750, Compound 155 | US9662...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50095232BDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 224338BDBM224338(US9321760, 15 | US10080750, Compound 15 | US966233...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 224350BDBM224350(US9321760, 27 | US10080750, Compound 27 | US966233...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182311BDBM182311(US9145392, 12)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182322BDBM182322(US9145392, 23)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182321BDBM182321(US9145392, 22)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50451248BDBM50451248(CHEMBL2368948)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Akt (proto-oncogenic serine/threonine) kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50451248BDBM50451248(CHEMBL2368948)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Akt (proto-oncogenic serine/threonine PKB) kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50204693BDBM50204693(3-(4'-hydroxy-biphenyl-4-yl)-1,4-dihydro-indeno[1,...)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of AKT by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182336BDBM182336(US9145392, 37)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50205472BDBM50205472(CHEMBL393929 | CHEMBL261644 | (Z)-5-(quinolin-6-yl...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50205477BDBM50205477((Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinol...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50205468BDBM50205468((Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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