Compile Data Set for Download or QSAR
Report error Found 127 Enz. Inhib. hit(s) with Target = 'RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]'
LigandChemical structure of BindingDB Monomer ID 373010BDBM373010(US9895376, Compound 2.30)
Affinity DataIC50: 0.25nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210021BDBM210021(US9273046, 2.27 | US9895376, Compound 2.27 | US105...)
Affinity DataIC50: 0.25nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210020BDBM210020(US9273046, 2.26 | US9895376, Compound 2.26 | US105...)
Affinity DataIC50: 0.25nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210051BDBM210051(US9273046, 2.29 | US9895376, Compound 2.29 | US105...)
Affinity DataIC50: 0.25nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210037BDBM210037(US9273046, 2.1 | US9895376, Compound 2.1 | US10576...)
Affinity DataIC50: 0.300nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210022BDBM210022(US9273046, 2.31 | US9895376, Compound 2.31 | US105...)
Affinity DataIC50: 0.350nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210015BDBM210015(US9273046, 2.21 | US9895376, Compound 2.21 | US105...)
Affinity DataIC50: 0.400nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322528BDBM322528(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322529BDBM322529(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 372977BDBM372977(US9895376, Compound 2.4a | US10576087, Compound 2....)
Affinity DataIC50: 0.540nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210044BDBM210044(US9273046, 2.4 | US9895376, Compound 2.4 | US10576...)
Affinity DataIC50: 0.560nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210024BDBM210024(US9273046, 2.33 | US9895376, Compound 2.33 | US105...)
Affinity DataIC50: 0.600nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322521BDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210002BDBM210002(US9273046, 2.8 | US9895376, Compound 2.8 | US10576...)
Affinity DataIC50: 0.710nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322521BDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210023BDBM210023(US9273046, 2.32 | US9895376, Compound 2.32 | US105...)
Affinity DataIC50: 0.900nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210016BDBM210016(US9273046, 2.22 | US9895376, Compound 2.22 | US105...)
Affinity DataIC50: 1nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322521BDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 372967BDBM372967(US9895376, Compound 2.2a | US10576087, Compound 2....)
Affinity DataIC50: 1.20nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210034BDBM210034(US9273046, 1.1 | US9895376, Compound 1.1 | US10576...)
Affinity DataIC50: 1.40nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210038BDBM210038(US9273046, 2.2 | US9895376, Compound 2.2 | US10576...)
Affinity DataIC50: 1.40nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210013BDBM210013(US9273046, 2.19 | US9895376, Compound 2.19 | US105...)
Affinity DataIC50: 1.60nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210007BDBM210007(US9273046, 2.13 | US9895376, Compound 2.28 | US105...)
Affinity DataIC50: 1.70nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210001BDBM210001(US9273046, 2.7 | US9895376, Compound 2.7 | US10576...)
Affinity DataIC50: 2.10nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 372978BDBM372978(US9895376, Compound 2.4b | US10576087, Compound 2....)
Affinity DataIC50: 2.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 372985BDBM372985(US9895376, Compound 2.5b | US10576087, Compound 2....)
Affinity DataIC50: 2.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 622280BDBM622280(4-amino-N-(1-((2-fluorophenyl)amino)-6-methylisoqu...)
Affinity DataIC50: 2.60nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 622284BDBM622284(4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-me...)
Affinity DataIC50: 2.68nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 238347BDBM238347(US9388165, 3)
Affinity DataIC50: 2.80nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 372973BDBM372973(US9895376, Compound 2.3a | US10576087, Compound 2....)
Affinity DataIC50: 3nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 622285BDBM622285(4-amino-N-(1-((2-fluoro-4-methoxyphenyl)amino)-6-m...)
Affinity DataIC50: 3.14nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210032BDBM210032(US9273046, 3.7 | US9895376, Compound 3.7 | US10576...)
Affinity DataIC50: 3.20nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210005BDBM210005(US9273046, 2.11 | US9895376, Compound 2.11 | US105...)
Affinity DataIC50: 3.30nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 622277BDBM622277(4-amino-N-(1-(4-chloro-2-fluorobenzoyl)-6-methylis...)
Affinity DataIC50: 3.48nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210009BDBM210009(US9273046, 2.15 | US9895376, Compound 2.15 | US105...)
Affinity DataIC50: 3.60nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 210010BDBM210010(US9273046, 2.16 | US9895376, Compound 2.16 | US105...)
Affinity DataIC50: 3.80nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 622276BDBM622276(4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)...)
Affinity DataIC50: 3.93nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322521BDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322540BDBM322540(5-[3-(5-phenyl-1H-pyrazol-3-yl)chroman-6-yl]oxy-3,...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322521BDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322541BDBM322541(5-[[(3S)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322525BDBM322525(5-[3[4-(4-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]o...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322542BDBM322542(5-[[(3R)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322527BDBM322527(5-[3-(4-tert-butyl-1H-imidazol-2-yl)chroman-6-yl]o...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322536BDBM322536(5-[3-[5-(1,3-benzodioxol-5-yl)-1H-imidazol-2-yl]ch...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322518BDBM322518(5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-di...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322537BDBM322537(5-[3-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imid...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322538BDBM322538(5-[[3-(4-phenyl-1H-imidazol-2-yl)-2H-chromen-6-yl]...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322521BDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 322532BDBM322532(5-[3-[4-(benzofuran-3-yl)-1H-imidazol-2-yl]chroman...)
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

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