Compile Data Set for Download or QSAR
Report error Found 104 Enz. Inhib. hit(s) with Target = 'RNA-binding protein FXR1'
TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  2nMAssay Description:Binding affinity to human FXR1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665692BDBM665692(US20240116912, Example 71 | 3-(6-((2R,4R)-4-((5-cy...)
Affinity DataEC50:  2.10nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665639BDBM665639(US20240116912, Example 18 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  2.90nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665687BDBM665687(US20240116912, Example 66 | 3-(6-((1R,3r,5S)-3-((5...)
Affinity DataEC50:  3nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665644BDBM665644(US20240116912, Example 23 | 3-(4-((2R,4R)-4-((5-cy...)
Affinity DataEC50:  3.10nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665671BDBM665671(US20240116912, Example 50 | 3-(4-((1R,F,5S)-3-((5-...)
Affinity DataEC50:  3.20nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665634BDBM665634(US20240116912, Example 13 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  3.5nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665624BDBM665624(US20240116912, Example 3 | 3-(4-(4-((5-cyclopropyl...)
Affinity DataEC50:  3.60nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665668BDBM665668(US20240116912, Example 47 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  3.70nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665627BDBM665627(US20240116912, Example 6 | 3-(6-(4-((5-cyclopropyl...)
Affinity DataEC50:  4.40nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665693BDBM665693(US20240116912, Example 72 | 3-(6-((2R,4R)-4-((3-(2...)
Affinity DataEC50:  4.5nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504302BDBM504302(3α,7α,11β,23-tetrahydroxy-6α-e...)
Affinity DataEC50:  7.5nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504302BDBM504302(3α,7α,11β,23-tetrahydroxy-6α-e...)
Affinity DataEC50:  7.5nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504302BDBM504302(3α,7α,11β,23-tetrahydroxy-6α-e...)
Affinity DataEC50:  7.5nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665635BDBM665635(US20240116912, Example 14 | 3-(2-chloro-4-(4-((5-c...)
Affinity DataEC50:  8.5nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665674BDBM665674(US20240116912, Example 53 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  9nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665646BDBM665646(US20240116912, Example 25 | 2-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  9.10nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665631BDBM665631(US20240116912, Example 10 | 6-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  9.10nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665690BDBM665690(US20240116912, Example 69 | 5-(6-((1R,3R,5S)-3-((5...)
Affinity DataEC50:  9.5nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  9.60nMAssay Description:Binding affinity to human FXR1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665664BDBM665664(US20240116912, Example 43 | 6-(6-(4-((5-cyclopropy...)
Affinity DataEC50:  11.2nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665670BDBM665670(US20240116912, Example 49 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  11.7nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665653BDBM665653(US20240116912, Example 32 | 3-(4-((3S,4R)-4-((5-cy...)
Affinity DataEC50:  12.6nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665688BDBM665688(US20240116912, Example 67 | 6-(4-((1R,3R,5S)-3-((5...)
Affinity DataEC50:  12.7nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504304BDBM504304(3α,7α,11β-rihydroxy-6α-ethyl-5...)
Affinity DataEC50:  15nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504304BDBM504304(3α,7α,11β-rihydroxy-6α-ethyl-5...)
Affinity DataEC50:  15nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504304BDBM504304(3α,7α,11β-rihydroxy-6α-ethyl-5...)
Affinity DataEC50:  15nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665660BDBM665660(US20240116912, Example 39 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  16.1nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665680BDBM665680(US20240116912, Example 59 | 5-(6-(4-((5-cyclopropy...)
Affinity DataEC50:  17.9nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665657BDBM665657(US20240116912, Example 36 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  18.8nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665665BDBM665665(US20240116912, Example 44 | 3-(4-(4-((3-(2-chlorop...)
Affinity DataEC50:  21.3nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665632BDBM665632(US20240116912, Example 11 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  21.9nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665686BDBM665686(US20240116912, Example 65 | 5-(4-((1R,3R,5S)-3-((5...)
Affinity DataEC50:  22.1nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665637BDBM665637(US20240116912, Example 16 | 5-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  24nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665689BDBM665689(US20240116912, Example 68 | 5-(6-((1R,3R,5S)-3-((5...)
Affinity DataEC50:  26.4nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665629BDBM665629(US20240116912, Example 8 | 3-(5-(4-((5-cyclopropyl...)
Affinity DataEC50:  28.1nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665659BDBM665659(US20240116912, Example 38 | 3-(5-(4-((5-cyclopropy...)
Affinity DataEC50:  28.6nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504311BDBM504311(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  29nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504311BDBM504311(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  29nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504306BDBM504306(US11034717, Compound B)
Affinity DataEC50:  30nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665626BDBM665626(US20240116912, Example 5 | 3-(2-(4-((5-cyclopropyl...)
Affinity DataEC50:  31nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665675BDBM665675(US20240116912, Example 54 | 3-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  37.6nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665669BDBM665669(US20240116912, Example 48 | 5-(4-(4-((5-cyclopropy...)
Affinity DataEC50:  41.6nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504310BDBM504310(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  42nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 504310BDBM504310(3α,7α,11β-trihydroxy-6α-ethyl-...)
Affinity DataEC50:  42nMAssay Description:AlphaScreen was used with the aim of identifying novel modulators by taking advantage of the bimolecular interaction prevailing between FXR and the L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665677BDBM665677(US20240116912, Example 56 | 3-(5-(4-((5-cyclopropy...)
Affinity DataEC50:  43.1nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665656BDBM665656(US20240116912, Example 35 | 3-(5-(4-((5-cyclopropy...)
Affinity DataEC50:  43.5nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665652BDBM665652(US20240116912, Example 31 | 3-(4-((3R,4S)-4-((5-cy...)
Affinity DataEC50:  45nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665694BDBM665694(US20240116912, Example 73 | 3-(6-((2R,4R)-4-((5-cy...)
Affinity DataEC50:  47.6nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetRNA-binding protein FXR1 [244-476](Human)
Terns Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 665658BDBM665658(US20240116912, Example 37 | 5-(6-(4-((5-cyclopropy...)
Affinity DataEC50:  49.4nMAssay Description:A cell free coactivator recruitment assay was developed for FXR, to measure the functional potency of novel FXR compounds. In this assay, novel FXR c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

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