Compile Data Set for Download or QSAR
Report error Found 190 Enz. Inhib. hit(s) with Target = 'Rap guanine nucleotide exchange factor 4'
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526580BDBM50526580(CHEMBL4549036)
Affinity DataEC50:  300nMAssay Description:Inhibition of 8Fluo-cAMP binding to DEP domain deficient mouse EPAC2 (280 to 988 residues) measured after 5 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425531BDBM50425531(CHEMBL2313646)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175225BDBM50175225(CHEMBL3808606)
Affinity DataIC50: 400nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425541BDBM50425541(CHEMBL2313637)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425555BDBM50425555(CHEMBL2313653)
Affinity DataIC50: 400nMAssay Description:Inhibition of EPAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175143BDBM50175143(CHEMBL3809313)
Affinity DataIC50: 400nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425539BDBM50425539(CHEMBL2313639)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425555BDBM50425555(CHEMBL2313653)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175266BDBM50175266(CHEMBL3808997)
Affinity DataIC50: 500nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175226BDBM50175226(CHEMBL3808936)
Affinity DataIC50: 500nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50011368BDBM50011368(CHEMBL3260989)
Affinity DataIC50: 600nMAssay Description:Inhibition of EPAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175100BDBM50175100(CHEMBL3809121)
Affinity DataIC50: 600nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425554BDBM50425554(CHEMBL2313654)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175228BDBM50175228(CHEMBL3808792)
Affinity DataIC50: 700nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 81292BDBM81292(8-Bromoadenosine 3',5'-cyclic monophosphat...)
Affinity DataEC50:  780nMAssay Description:Inhibition of 8Fluo-cAMP binding to DEP domain deficient mouse EPAC2 (280 to 988 residues) measured after 5 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098793BDBM50098793(CHEMBL3593342)
Affinity DataIC50: 900nMAssay Description:Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425542BDBM50425542(CHEMBL2313636)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098793BDBM50098793(CHEMBL3593342)
Affinity DataIC50: 900nMAssay Description:Displacement of 8-NBD-cAMP from mouse EPAC2 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175225BDBM50175225(CHEMBL3808606)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EPAC2 (unknown origin) assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal tru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175273BDBM50175273(CHEMBL3808989)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098792BDBM50098792(CHEMBL3593343)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175270BDBM50175270(CHEMBL3808484)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175227BDBM50175227(CHEMBL3809399)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 89901BDBM89901(1-(2,4,6-Trimethyl-benzenesulfonyl)-1H-indole | SM...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50452020BDBM50452020(CHEMBL4213611)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at recombinant full length EPAC2 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517717BDBM517717(ZL0524 | US11124489, Entry 32)
Affinity DataIC50: 1.20E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175100BDBM50175100(CHEMBL3809121)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of EPAC2 (unknown origin) assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal tru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425532BDBM50425532(CHEMBL2313645)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175265BDBM50175265(CHEMBL3808689)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175267BDBM50175267(CHEMBL3809943)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175268BDBM50175268(CHEMBL3809058)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098713BDBM50098713(CHEMBL3593335)
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175143BDBM50175143(CHEMBL3809313)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of EPAC2 (unknown origin) assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal tru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175070BDBM50175070(CHEMBL3809465)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50326557BDBM50326557(NSC45576, 2 | CHEMBL1253920 | (E)-5-((2-hydroxynap...)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175071BDBM50175071(CHEMBL3809991)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175069BDBM50175069(CHEMBL3808996)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175101BDBM50175101(CHEMBL3810034)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175264BDBM50175264(CHEMBL3810082)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098719BDBM50098719(CHEMBL3593329)
Affinity DataIC50: 1.90E+3nMAssay Description:Displacement of 8-NBD-cAMP from mouse EPAC2 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241952BDBM50241952(CHEMBL4099528)
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098719BDBM50098719(CHEMBL3593329)
Affinity DataIC50: 1.90E+3nMAssay Description:Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2016
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517689BDBM517689(NY0562 | US11124489, Compound 33)
Affinity DataIC50: 1.90E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425550BDBM50425550(CHEMBL2313658)
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175139BDBM50175139(CHEMBL3810304)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50526578BDBM50526578(CHEMBL4468490)
Affinity DataEC50:  2.06E+3nMAssay Description:Inhibition of 8Fluo-cAMP binding to DEP domain deficient mouse EPAC2 (280 to 988 residues) measured after 5 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241967BDBM50241967(CHEMBL4087626)
Affinity DataIC50: 2.20E+3nMAssay Description:Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175068BDBM50175068(CHEMBL3809695)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241961BDBM50241961(CHEMBL4081514)
Affinity DataIC50: 2.20E+3nMAssay Description:Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 517666BDBM517666(NY0617 | US11124489, Compound 10)
Affinity DataIC50: 2.20E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

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