Compile Data Set for Download or QSAR
Report error Found 4075 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 1'
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787109BDBM787109(Preparation of (2R)-2-amino-2-(3-methoxyphenyl)-N-...)
Affinity DataIC50: 0.180nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787121BDBM787121((2S)-3-amino-2-benzyl-N-[3-(1H-pyrazol-4-yl)-1H-in...)
Affinity DataIC50: 0.180nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787093BDBM787093(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-amino-2-cy...)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 50546246BDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human ROCK1 expressed in baculovirus expression system by Kinase-Glo luminescent AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 50546246BDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of recombinant human GST-tagged ROCK1 catalytic domain expressed in baculovirus expression system by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 252239BDBM252239(US9458110, 309)
Affinity DataIC50: 0.200nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598584BDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 50546246BDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787082BDBM787082(Preparation of (2S)-2-amino-2-phenyl-N-[3-(1H-pyra...)
Affinity DataIC50: 0.240nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 252174BDBM252174(US9458110, 246)
Affinity DataIC50: 0.260nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  0.280nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787154BDBM787154(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-amino-2-(m...)
Affinity DataIC50: 0.290nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787088BDBM787088(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-amino-2-(3...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787117BDBM787117(3-(1-((3-(1H-pyrazol-4-yl)-1H-indol-7-yl)amino)-3-...)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787107BDBM787107(US20250346616, Example 40)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787077BDBM787077(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-amino-2-(4...)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787131BDBM787131(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-amino-2-(3...)
Affinity DataIC50: 0.370nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787147BDBM787147(3-amino-2-(4-aminophenyl)-N-[3-(1H-pyrazol-4-yl)-1...)
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 252175BDBM252175(US9458110, 247)
Affinity DataIC50: 0.390nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 569251BDBM569251(US11427563, Compound 120 | US11427563, Compound 11...)
Affinity DataIC50: 0.400nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 569271BDBM569271(US11427563, Compound 86 | US11427563, Compound 146)
Affinity DataIC50: 0.400nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 569271BDBM569271(US11427563, Compound 86 | US11427563, Compound 146)
Affinity DataIC50: 0.400nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787171BDBM787171(2-[4-(2-aminoethyl) piperazin-1-yl]-2-phenyl-N-[3-...)
Affinity DataIC50: 0.420nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787130BDBM787130(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-amino-2-(5...)
Affinity DataIC50: 0.430nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 252176BDBM252176(US9458110, 248)
Affinity DataIC50: 0.430nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787105BDBM787105(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-(4-methylp...)
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.444nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 572304BDBM572304(4-(2,7- diazaspiro[4.4]nonan-2- yl)-3-pyridazin-4-...)
Affinity DataKi:  0.448nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 376380BDBM376380(US9914740, VIII-6 | N-((R)-1-(3-methoxyphenyl) eth...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 569350BDBM569350(US11427563, Compound 125)
Affinity DataIC50: 0.5nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787112BDBM787112(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-2-(1-methylp...)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 199250BDBM199250(US9221808, 1bo-HCl | US9221808, 1bo-Mes | US922180...)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787100BDBM787100(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-amino-2-(p...)
Affinity DataIC50: 0.550nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787076BDBM787076(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-amino-2-(4...)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 412136BDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 412136BDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human ROCK1More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787190BDBM787190(N-(2-amino-1-(3-methoxyphenyl)ethyl)-3-(1H-pyrazol...)
Affinity DataIC50: 0.620nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 139540BDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 0.627nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 50089584BDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 50089584BDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 50089584BDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of ROCK1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787104BDBM787104(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-3-(4-methylp...)
Affinity DataIC50: 0.710nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787186BDBM787186(N-(3-(1H-pyrazol-4-yl)-1H-indol-7-yl)-2-amino-2-(p...)
Affinity DataIC50: 0.760nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 252182BDBM252182(US9458110, 254)
Affinity DataIC50: 0.770nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.799nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 50546544BDBM50546544(CHEMBL4791701)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH peptide substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 252182BDBM252182(US9458110, 254)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH peptide substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

US Patent
LigandChemical structure of BindingDB Monomer ID 787152BDBM787152(3-amino-2-(4-fluorophenyl)-N-[3-(1H-pyrazol-4-yl)-...)
Affinity DataIC50: 0.810nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/5/2026
Entry Details US Patent

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