Compile Data Set for Download or QSAR
Report error Found 124 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 1/2'
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25472BDBM25472(N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benz...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human ROCK incubated for 20 mins followed by 33P ATP after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196694BDBM50196694(N-(1-(thiophen-3-ylmethyl)piperidin-3-yl)-1H-indaz...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196700BDBM50196700(N-[1-(3-nitrobenzyl)-3-piperidyl]-N-(1H-5-indazoly...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196718BDBM50196718(N-(1-(thiophen-2-ylmethyl)piperidin-3-yl)-1H-indaz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525584BDBM50525584(CHEMBL4453941)
Affinity DataKi:  6nMAssay Description:Inhibition of ROCK (unknown origin) using Myelin Basic Protein as substrate incubated for 60 mins in presence of [33P] gammaATP by microbeta liquid s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196692BDBM50196692(N-(1-(4-methylbenzyl)piperidin-3-yl)-1H-indazol-5-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196695BDBM50196695(N-(1-(3,4-difluorobenzyl)piperidin-3-yl)-1H-indazo...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196690BDBM50196690(N-(1-(4-aminobenzyl)piperidin-3-yl)-1H-indazol-5-a...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196711BDBM50196711(1-benzyl-3-piperidyl-(1H-5-indazolyl)ether | 5-(1-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196689BDBM50196689(N-[1-(1H-2-pyrrolylmethyl)-3-piperidyl]-N-(1H-5-in...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196682BDBM50196682(N-(1-(4-chlorobenzyl)piperidin-3-yl)-1H-indazol-5-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519606BDBM50519606(CHEMBL4448462)
Affinity DataIC50: 12nMAssay Description:Inhibition of human ROCK incubated for 20 mins followed by 33P ATP after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506948BDBM50506948(CHEMBL4448806)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196707BDBM50196707(N-[1-(2-chlorobenzyl)-3-piperidyl]-N-(1H-5-indazol...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196712BDBM50196712(N-(1-(4-methoxybenzyl)piperidin-3-yl)-1H-indazol-5...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196704BDBM50196704(1-benzyl-N-(1H-indazol-5-yl)piperidine-3-carboxami...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196728BDBM50196728(N-[1-(3-chlorobenzyl)-3-piperidyl]-N-(1H-5-indazol...)
Affinity DataIC50: 19nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196698BDBM50196698(N-[1-(3-chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazo...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196725BDBM50196725(N-(1-benzylpiperidin-3-yl)-1H-indazol-5-amine | N-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196687BDBM50196687(1-(2,6-dichlorophenyl)-3-(3H-indazol-5-yl)urea | 1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196725BDBM50196725(N-(1-benzylpiperidin-3-yl)-1H-indazol-5-amine | N-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196686BDBM50196686(N-[1-(4-chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazo...)
Affinity DataIC50: 24nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197913BDBM50197913((3R)-N-[1-(3-aminobenzyl)-3-pyrrolidyl]-N-(5-isoqu...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196688BDBM50196688(N-(1-(4-fluorobenzyl)piperidin-3-yl)-1H-indazol-5-...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196708BDBM50196708(N-(1-benzylpyrrolidin-3-yl)-1H-indazol-5-amine | N...)
Affinity DataIC50: 32nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196699BDBM50196699(N-[1-(3-aminobenzyl)-3-piperidyl]-N-(1H-5-indazoly...)
Affinity DataIC50: 35nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196679BDBM50196679(N-[1-(2-chlorobenzyl)-3-pyrrolidyl]-N-(1H-5-indazo...)
Affinity DataIC50: 45nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506928BDBM50506928(CHEMBL4469434)
Affinity DataIC50: 56nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197914BDBM50197914(N-(1-(4-chlorobenzyl)pyrrolidin-3-yl)isoquinolin-5...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196706BDBM50196706(N-(1-(furan-2-ylmethyl)piperidin-3-yl)-1H-indazol-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197915BDBM50197915(N-(1-(3-chlorobenzyl)pyrrolidin-3-yl)isoquinolin-5...)
Affinity DataIC50: 65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197922BDBM50197922(anti-N1-cyclopropyl-N4-(isoquinolin-5-yl)cyclohexa...)
Affinity DataIC50: 70nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196683BDBM50196683(N-[1-(3-pyridylmethyl)-3-piperidyl]-N-(1H-5-indazo...)
Affinity DataIC50: 72nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506932BDBM50506932(CHEMBL2006299)
Affinity DataIC50: 75nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197907BDBM50197907(N-(1-(2,6-difluorobenzyl)pyrrolidin-3-yl)isoquinol...)
Affinity DataIC50: 75nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196685BDBM50196685(N-(1-(3,5-dimethoxybenzyl)piperidin-3-yl)-1H-indaz...)
Affinity DataIC50: 80nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196681BDBM50196681(N-(2,6-difluorobenzyl)-N0-(1H-5-indazolyl)urea | 1...)
Affinity DataIC50: 85nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196702BDBM50196702(N-[1-(2-aminobenzyl)-3-piperidyl]-N-(1H-5-indazoly...)
Affinity DataIC50: 85nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196691BDBM50196691(N-(1-(4-nitrobenzyl)piperidin-3-yl)-1H-indazol-5-a...)
Affinity DataIC50: 87nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506931BDBM50506931(CHEMBL4465725)
Affinity DataIC50: 94nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197900BDBM50197900(N-[1-(4-fluorobenzyl)-3-pyrrolidyl]-N-(5-isoquinol...)
Affinity DataIC50: 95nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 148412BDBM148412(US9682963, 5)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 148410BDBM148410(US9682963, 4)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 148408BDBM148408(US9682963, 2)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 148425BDBM148425(US9682963, 13)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetRho-associated protein kinase 1/2(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196696BDBM50196696(1-benzyl-4-piperidyl-(1H-5-indazolyl)ether | 5-(1-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 148423BDBM148423(US9682963, 12)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 148421BDBM148421(US9682963, 11)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 148416BDBM148416(US9682963, 9)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 148414BDBM148414(US9682963, 7)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

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