Compile Data Set for Download or QSAR
Report error Found 260 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 2 [1-552]'
TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598601BDBM598601(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598664BDBM598664(US11613531, Example 342 | Ethyl 2-(3,8-diazabicycl...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598596BDBM598596(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598630BDBM598630(US11613531, Example 301 | N-(2-(3,6-diazabicyclo[3...)
Affinity DataIC50: 0.400nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598602BDBM598602(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 0.400nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598581BDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50: 0.900nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598603BDBM598603(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 1nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598647BDBM598647(US11613531, Example 319 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 1.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598604BDBM598604(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 1.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578446BDBM578446((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chloropheny...)
Affinity DataIC50: 1.20nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598655BDBM598655(US11613531, Example 332 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578479BDBM578479((S) N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-...)
Affinity DataIC50: 1.60nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598584BDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50: 1.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598562BDBM598562(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)pyrimidin...)
Affinity DataIC50: 1.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578424BDBM578424(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-chlorophenyl)-2...)
Affinity DataIC50: 1.70nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598666BDBM598666(US11613531, Example 344 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578438BDBM578438((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50: 1.80nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598652BDBM598652(US11613531, Example 329 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578449BDBM578449(3-(2-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-(methyla...)
Affinity DataIC50: 1.90nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598631BDBM598631(US11613531, Example 302 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 2.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598606BDBM598606(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3,8-diazabicyclo[...)
Affinity DataIC50: 2.30nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578470BDBM578470(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 2.40nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598636BDBM598636(US11613531, Example 307 | 2-(3,6-diazabicyclo[3.1....)
Affinity DataIC50: 2.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578435BDBM578435((R) N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...)
Affinity DataIC50: 2.90nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578410BDBM578410((S) N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50: 3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578409BDBM578409(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(2-methoxyphenyl)-...)
Affinity DataIC50: 3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578454BDBM578454(N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-pyra...)
Affinity DataIC50: 3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598517BDBM598517(US11613531, Example 228 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 3nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578415BDBM578415(US11479533, Example 11 | US11479533, Example 21 | ...)
Affinity DataIC50: 3.10nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578420BDBM578420(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-chlorophenyl)-2...)
Affinity DataIC50: 3.5nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598659BDBM598659(US11613531, Example 336 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 3.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598579BDBM598579(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluorop...)
Affinity DataIC50: 3.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598597BDBM598597(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro...)
Affinity DataIC50: 3.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598639BDBM598639(US11613531, Example 310 | 2-(3,6-diazabicyclo[3.1....)
Affinity DataIC50: 3.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578411BDBM578411(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 4nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578415BDBM578415(US11479533, Example 11 | US11479533, Example 21 | ...)
Affinity DataIC50: 4nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578423BDBM578423(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-fluorophenyl)-2...)
Affinity DataIC50: 4.80nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598594BDBM598594(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-chloro...)
Affinity DataIC50: 4.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598586BDBM598586(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-methoxy...)
Affinity DataIC50: 5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578430BDBM578430(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 5.30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578476BDBM578476(N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)-2-((2-meth...)
Affinity DataIC50: 5.30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598665BDBM598665(US11613531, Example 343 | 4-((1H-indazol-5-yl)amin...)
Affinity DataIC50: 5.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598663BDBM598663(US11613531, Example 341 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 5.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598577BDBM598577(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...)
Affinity DataIC50: 5.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598654BDBM598654(US11613531, Example 331 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 5.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578417BDBM578417(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(ethylamino)-2-(3-...)
Affinity DataIC50: 6.30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578421BDBM578421(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chlorophenyl)-2...)
Affinity DataIC50: 6.30nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578461BDBM578461(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50: 6.5nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 598598BDBM598598(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 6.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 578418BDBM578418(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(methylamino)-2-(m...)
Affinity DataIC50: 6.80nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

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