Compile Data Set for Download or QSAR
Report error Found 3956 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1'
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33202(benzisoxazole, 1)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33203(quinazolinone, 2)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33204(N-phenylquinazolin-4-amine, 3)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33205(N-(3-methoxybenzyl)quinazolin-4-amine, 4)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33206(thiazoloazepinyl acetamide, 5)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33207(benzothienopyrimidinone, 6)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33208(thiazole, 7)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33209(2-methylsulfanyl imidazol-4-one, 8)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33210(4-(7H-purin-6-yl)morpholine | purine, 9)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33203(quinazolinone, 2)
Affinity DatapH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33206(thiazoloazepinyl acetamide, 5)
Affinity DatapH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33208(thiazole, 7)
Affinity DatapH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33209(2-methylsulfanyl imidazol-4-one, 8)
Affinity DatapH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  1.20E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  1.90E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  540nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  1.30E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  1.20E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  3.20nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  300nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM91830(Chk1_104)
Affinity DataEC50: >1.00E+4nMAssay Description:ChemBL affinity - Published Abbott papersMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2012
Entry Details PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50254806(CHEMBL4066399)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50254814(CHEMBL4059912)
Affinity DataEC50:  8nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255141(CHEMBL4076939)
Affinity DataEC50:  3.70E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255155(CHEMBL4097424)
Affinity DataEC50:  840nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255163(CHEMBL4067770)
Affinity DataEC50:  30nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255165(CHEMBL4071952)
Affinity DataEC50:  60nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255210(CHEMBL4082801)
Affinity DataEC50:  410nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255167(CHEMBL4066751)
Affinity DataEC50:  150nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255168(CHEMBL4094277)
Affinity DataEC50:  2.30E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255173(CHEMBL4097937)
Affinity DataEC50:  12nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255160(CHEMBL4089699)
Affinity DataEC50:  340nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50254801(CHEMBL4104102)
Affinity DataEC50:  30nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255162(CHEMBL4105353)
Affinity DataEC50:  70nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50332136((S)-2-phenyl-4-(piperidin-3-ylamino)thieno[3,2-c]p...)
Affinity DataEC50:  26nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50254810(CHEMBL4100776)
Affinity DataEC50:  50nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255164(CHEMBL4096683)
Affinity DataEC50:  53nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255161(CHEMBL4081097)
Affinity DataEC50:  390nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255214(CHEMBL4088986)
Affinity DataEC50:  40nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50254805(CHEMBL4093952)
Affinity DataEC50:  10nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255213(CHEMBL4068572)
Affinity DataEC50:  210nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255216(CHEMBL4081827)
Affinity DataEC50:  880nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255178(CHEMBL4079910)
Affinity DataEC50:  10nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255208(CHEMBL4098878)
Affinity DataEC50:  24nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255144(CHEMBL4079391)
Affinity DataEC50:  110nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50243258((S)-1-(5-phenyl-3-(piperidin-3-ylcarbamoyl)thiophe...)
Affinity DataEC50:  19nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50255177(CHEMBL4104408)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin-induced G2/M phase arrestMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  20nMAssay Description:Binding affinity to recombinant human full-length N-terminal His-tagged CHEK1 expressed in baculovirus expression system using CHKtide as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50195218(3-(5-(morpholinomethyl)-1H-indol-2-yl)-6-(1H-pyraz...)
Affinity DataEC50:  170nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM50195216(3-(5-((4-fluoropiperidin-1-yl)methyl)-1H-indol-2-y...)
Affinity DataEC50:  120nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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