Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with Target = 'Serum paraoxonase/arylesterase 1'
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139137BDBM50139137(CHEMBL3759162)
Affinity DataKi:  2.39E+3nMAssay Description:Competitive inhibition of human serum PON1 using paraoxon as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 86068BDBM86068(PPC)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139137BDBM50139137(CHEMBL3759162)
Affinity DataIC50: 6.37E+3nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594668BDBM50594668(CHEMBL5174712)
Affinity DataIC50: 7.84E+3nMAssay Description:Inhibition of human PON1 using paraoxon as a substrate by regression analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144692BDBM50144692(CHEMBL3759251)
Affinity DataIC50: 8.76E+3nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 92331BDBM92331(Lornoxicam)
Affinity DataKi:  9.00E+3nM ΔG°:  -28.8kJ/mole IC50: 1.36E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50454598BDBM50454598(CHEMBL4215208)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158481BDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50454599BDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001839BDBM50001839(CHEMBL428647 | taxol | PACLITAXEL)
Affinity DataKi:  1.65E+4nM IC50: 4.20E+4nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2016
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144693BDBM50144693(CHEMBL3758983)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139133BDBM50139133(CHEMBL3759178)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139135BDBM50139135(CHEMBL3759775)
Affinity DataIC50: 2.37E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144739BDBM50144739(CHEMBL3759516)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139132BDBM50139132(CHEMBL1462074)
Affinity DataIC50: 3.14E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139134BDBM50139134(CHEMBL3758686)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50316126BDBM50316126(Cetamide | Klaron | Sulfacel-15 | SULF-15 | N-Acet...)
Affinity DataKi:  8.60E+4nM IC50: 1.80E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2011
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17638BDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataKi:  9.70E+4nM ΔG°:  -22.9kJ/mole IC50: 1.95E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 243044BDBM243044((2-Bromo-4,5-dimethoxyphenyl)(2,3-dibromo-5,6-dime...)
Affinity DataIC50: 1.23E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 243045BDBM243045((3-Bromo-4,5-dimethoxyphenyl)(2,3-dibromo-5,6-dime...)
Affinity DataIC50: 1.25E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127140BDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataKi:  1.31E+5nM IC50: 2.26E+5nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2016
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 243043BDBM243043((2,3-dibromo-5,6-dimethoxyphenyl)(3,4-dimethoxyphe...)
Affinity DataIC50: 1.74E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10860BDBM10860(aromatic sulfonamide compound 6 | 4-(aminomethyl)b...)
Affinity DataKi:  3.40E+5nM IC50: 1.90E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2011
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 241973BDBM241973(Oxytetracycline hydrochloride)
Affinity DataKi:  2.00E+5nMAssay Description:PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144690BDBM50144690(CHEMBL3759001)
Affinity DataIC50: 2.38E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 82185BDBM82185(Sulfosalazine, 3)
Affinity DataKi:  5.70E+5nM IC50: 2.60E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2011
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36351BDBM36351(CID148124 | Docetaxel)
Affinity DataKi:  2.91E+5nM IC50: 6.65E+5nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2016
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 92332BDBM92332(Tenoxicam)
Affinity DataKi:  3.06E+5nM ΔG°:  -20.1kJ/mole IC50: 3.40E+5nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139136BDBM50139136(CHEMBL3759337)
Affinity DataIC50: 3.17E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25902BDBM25902(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
Affinity DataKi:  7.02E+5nM IC50: 3.60E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2011
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144740BDBM50144740(CHEMBL3758357)
Affinity DataIC50: 5.64E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144738BDBM50144738(CHEMBL3758838)
Affinity DataIC50: 6.26E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144691BDBM50144691(CHEMBL3759697)
Affinity DataIC50: 6.27E+5nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 243048BDBM243048((3-Bromo-4,5-dihydroxyphenyl)(2,3-dibromo-5,6-dihy...)
Affinity DataIC50: 7.01E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10880BDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  7.43E+5nM IC50: 8.00E+5nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2011
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50174201BDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)
Affinity DataKi:  8.05E+5nM ΔG°:  -17.7kJ/mole IC50: 1.64E+6nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 243046BDBM243046((2,3-Dibromo-5,6-dihydroxyphenyl)(3,4-dihydroxyphe...)
Affinity DataIC50: 8.32E+5nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 243047BDBM243047((2-Bromo-4,5-dihydroxyphenyl)(2,3-dibromo-5,6-dihy...)
Affinity DataIC50: 1.11E+6nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 243042BDBM243042((2,3-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanon...)
Affinity DataIC50: 1.21E+6nMAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10868BDBM10868(1,3,4-thiadiazole-2-sulfonamide 15 | 5-amino-1,3,4...)
Affinity DataKi:  2.00E+6nM IC50: 1.24E+6nMAssay Description:The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2011
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127646BDBM50127646(Phosphoric acid 4-amino-phenyl ester diethyl ester...)
Affinity DataIC50: 1.28E+6nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144742BDBM50144742(CHEMBL3758332)
Affinity DataIC50: 2.06E+6nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14675BDBM14675(CHEMBL26128 | phenoxyphosphonic acid | Fragment 5 ...)
Affinity DataIC50: 3.25E+6nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127647BDBM50127647(Phosphoric acid diethyl ester phenyl ester | CHEMB...)
Affinity DataIC50: 3.27E+6nMAssay Description:Inhibitory activity against human serum paraoxonase (PON1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50144741BDBM50144741(CHEMBL3760112)
Affinity DataIC50: 3.33E+6nMAssay Description:Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 241974BDBM241974(Netilmycin sulfate)
Affinity DataKi:  3.73E+6nMAssay Description:PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50022271BDBM50022271(2-(3-benzoylphenyl)propanoic acid | 2-(3-Benzoylph...)
Affinity DataKi:  1.30E+7nM ΔG°:  -10.8kJ/mole IC50: 6.23E+6nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 189358BDBM189358(N,3-bis(2-chloroethyl)-2-oxo-1,3,2-oxazaphosphinan...)
Affinity DataKi:  8.97E+6nM IC50: 2.33E+7nMpH: 10.5Assay Description:Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2016
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 92333BDBM92333(Lincomycine)
Affinity DataKi:  1.11E+7nM ΔG°:  -11.2kJ/mole IC50: 1.30E+7nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
In£N£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50335522BDBM50335522((2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3...)
Affinity DataKi:  1.83E+7nMAssay Description:PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
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