Compile Data Set for Download or QSAR
Report error Found 92 Enz. Inhib. hit(s) with Target = 'Short transient receptor potential channel 3'
LigandPNGBDBM50439217(CHEMBL2418811)
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM542462(5-fluoro-1-[4-(4-fluorophenyl)-2-pyrimidin-4-yloxy...)
Affinity DataIC50: 3.68nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542444(5-fluoro-1-[4-(4-fluorophenyl)-2-(tetrazol-2-yl) c...)
Affinity DataIC50: 4.03nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542143(1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...)
Affinity DataIC50: 4.28nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM50439218(CHEMBL2418809)
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM542121(1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...)
Affinity DataIC50: 5.39nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542199(1-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophe...)
Affinity DataIC50: 6.22nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542439(5-fluoro-1-[4-(4-fluorophenyl)-2-pyrazol-1-yl-cycl...)
Affinity DataIC50: 6.64nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542457(6-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophe...)
Affinity DataIC50: 7.20nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542445(1-[4-(4-fluorophenyl)-2-(tetrazol-2-yl)cyclopentyl...)
Affinity DataIC50: 7.55nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542437(1-[4-(4-fluorophenyl)-2-pyrazol-1-yl-cyclopentyl] ...)
Affinity DataIC50: 7.97nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542111(1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...)
Affinity DataIC50: 8.31nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM50638824(CHEMBL5558723)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM542456(1-[2-(4-chloropyridazin-3-yl)oxy-4-(4-fluorophenyl...)
Affinity DataIC50: 11.3nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542446(1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...)
Affinity DataIC50: 14.3nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542443(5-fluoro-1-[4-(4-fluorophenyl)-2-(1,2,4-triazol-1-...)
Affinity DataIC50: 16nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542201(1-[2-(3-amino-4,4-difluoro-1-piperidyl)-4-(4-fluor...)
Affinity DataIC50: 17.5nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542002(1-[4-(4-fluorophenyl)-2-(triazol-2-yl)cyclopentyl]...)
Affinity DataIC50: 17.7nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM50239161(CHEMBL4085233)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
LigandPNGBDBM542448(4-[2-(3-amino-1-piperidyl)-4-(4-fluoro-3-methoxy-p...)
Affinity DataIC50: 22.5nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542463(2-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...)
Affinity DataIC50: 24nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542464(5-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...)
Affinity DataIC50: 25.5nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542459(6-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...)
Affinity DataIC50: 25.5nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM50439218(CHEMBL2418809)
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM542461(1-[4-(4-fluorophenyl)-2-pyridazin-3-yloxy-cyclopen...)
Affinity DataIC50: 32.2nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542453(2-[2-(3-amino-1-piperidyl)-4-phenyl-cyclopentoxy] ...)
Affinity DataIC50: 38.8nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542465(5-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...)
Affinity DataIC50: 39.2nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542451(4-[2-(5-amino-3,3-difluoro-1-piperidyl)-4-(4-fluor...)
Affinity DataIC50: 42.5nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542450(4-[2-(3-amino-4,4-difluoro-1-piperidyl)-4-(4-fluor...)
Affinity DataIC50: 46.1nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542119(1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...)
Affinity DataIC50: 46.4nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542460(6-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...)
Affinity DataIC50: 50.7nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542447(4-[2-(3-amino-1-piperidyl)-4-(4-fluoro-3-hydroxy-p...)
Affinity DataIC50: 58.8nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542452(4-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...)
Affinity DataIC50: 64.5nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542449(4-[2-(3-amino-1-piperidyl)-4-(3-fluorophenyl) cycl...)
Affinity DataIC50: 69.5nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM542454(4-[2-(3-amino-1-piperidyl)-4-phenyl-cyclopentoxy]-...)
Affinity DataIC50: 72.3nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM50439220(CHEMBL2418807)
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50439217(CHEMBL2418811)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM542455(6-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophe...)
Affinity DataIC50: 118nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM50239160(CHEMBL4060387)
Affinity DataEC50:  138nMAssay Description:Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
LigandPNGBDBM50439219(CHEMBL2418808)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM542458(l-[4-(4-fluorophenyl)-2-(5-fluoropyridazin-3-yl)ox...)
Affinity DataIC50: 209nMAssay Description:For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

LigandPNGBDBM50239162(CHEMBL4060400)
Affinity DataEC50:  236nMAssay Description:Agonist activity at human TRPC3 expressed in HEK293 cells assessed as induction of membrane depolarization measured for 2.5 mins in presence of 0.5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
LigandPNGBDBM50439216(CHEMBL2418812)
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50439221(CHEMBL2418806)
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50273009(CHEMBL4129809)
Affinity DataIC50: 282nMAssay Description:Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50439214(CHEMBL2418814)
Affinity DataIC50: 316nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50439213(CHEMBL2418815)
Affinity DataIC50: 316nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50557651(CHEMBL4761535)
Affinity DataIC50: 370nMAssay Description:Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in absence of extracellular calcium by whole cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50439227(CHEMBL2418823)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50557651(CHEMBL4761535)
Affinity DataIC50: 430nMAssay Description:Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in presence of 2 mM extracellular calcium by who...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
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