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Report error Found 1536 Enz. Inhib. hit(s) with Target = 'Solute carrier family 22 member 1'
TargetSolute carrier family 22 member 1(Bovine)
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM29568([3H]-Minipress | [3H]-Furazosin | PRAZOSIN HYDROCH...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetSolute carrier family 22 member 1(Bovine)
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM81444(NSC_185453 | CAS_185453 | WB 4101 | WB-4101)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM165905(US9067922, 247)
Affinity DataIC50: 1nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetSolute carrier family 22 member 1(Bovine)
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM50033312(Urapidil-5-methyl | CHEMBL539806 | Benzyl-(6-chlor...)
Affinity DataKi:  1.99nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50239134(CHEMBL4087516)
Affinity DataIC50: 2nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM165898(US9067922, 239)
Affinity DataIC50: 2nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM165900(US9067922, 241)
Affinity DataIC50: 3nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612481(CHEMBL5271398)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 11(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of OAT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50625677(CHEMBL5414132)
Affinity DataIC50: 4nMAssay Description:Inhibition of URAT1 (unknown origin) assessed as decrease in uric acid level measured after 15 minsMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50546900(CHEMBL4756866)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50625676(CHEMBL5399348)
Affinity DataIC50: 6nMAssay Description:Inhibition of URAT1 (unknown origin) assessed as decrease in uric acid level measured after 15 minsMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 1(Bovine)
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM86757(NSC_11603174 | CAS_0 | [11C]MMP)
Affinity DataKi:  6.75nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM165745(US9067922, 235 | US9067922, 79)
Affinity DataIC50: 7nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of URAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612476(CHEMBL5277301)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612472(CHEMBL5284974)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612468(CHEMBL5287151)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612477(CHEMBL5289202)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM165896(US9067922, 237)
Affinity DataIC50: 8nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM290450(2{[4-(4-Cyanonaphthalen)isoquinolin-6-yl]thio}-2-m...)
Affinity DataIC50: 8nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612478(CHEMBL5269373)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612475(CHEMBL5278085)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612464(CHEMBL5279672)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612485(CHEMBL5289441)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612465(CHEMBL5273217)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612469(CHEMBL5277066)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50239146(CHEMBL4088988)
Affinity DataIC50: 10nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM152051(US8987473, 137)
Affinity DataIC50: 10nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The resultin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612490(CHEMBL5268478)
Affinity DataIC50: 10nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 1(Bovine)
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM82424(CAS_1236 | NSC_1236 | Niguldipine(+))
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612488(CHEMBL5290258)
Affinity DataIC50: 10nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM290480(US10100016, Compound 45B)
Affinity DataIC50: 10nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM152041(US8987473, 122)
Affinity DataIC50: 10nMAssay Description:It was introduced human URAT1 full-length cDNA into an expression vector pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The resultin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612470(CHEMBL5291373)
Affinity DataIC50: 11nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612491(CHEMBL5267727)
Affinity DataIC50: 11nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612479(CHEMBL5285786)
Affinity DataIC50: 11nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612463(CHEMBL5267010)
Affinity DataIC50: 11nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612482(CHEMBL5282615)
Affinity DataIC50: 11nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM290470(US10100016, Compound 43A)
Affinity DataIC50: 11nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612487(CHEMBL5290341)
Affinity DataIC50: 12nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612471(CHEMBL5282586)
Affinity DataIC50: 12nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612480(CHEMBL5268476)
Affinity DataIC50: 12nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM290481(3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2,2...)
Affinity DataIC50: 12nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM165893(US9067922, 232)
Affinity DataIC50: 12nMpH: 7.4Assay Description:Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM318948(US10173990, Example 72 | 2-Methyl-2-[[7-(4-nitroph...)
Affinity DataIC50: 12nMAssay Description:URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612493(CHEMBL5266247)
Affinity DataIC50: 12nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM50612466(CHEMBL5285533)
Affinity DataIC50: 12nMAssay Description:Inhibition of human URAT1 mediated 14C-uric acid uptake expressed in HEK293 cells using 14C-uric acid as substrate incubated for 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
Pfizer

US Patent
LigandPNGBDBM290489(3-[4-(4-Cyanophenyl)thieno[2,3-c]pyridin-2-yl]-2,2...)
Affinity DataIC50: 12nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

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