Compile Data Set for Download or QSAR
Report error Found 1613 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8'
LigandPNGBDBM50268750(CHEMBL4064391)
Affinity DataEC50:  0.00100nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268748(CHEMBL4069241)
Affinity DataEC50:  0.00200nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268747(CHEMBL4070838)
Affinity DataEC50:  0.00400nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50613663(CHEMBL5287633)
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50465610(CHEMBL4295040)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50268769(CHEMBL4087522)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50268773(CHEMBL4075397)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM256277(US9487488, 1)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at TRPM8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM256277(US9487488, 1)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM50268764(CHEMBL4099556)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM256293(US9487488, 17)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM50268837(CHEMBL4072494)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 0.413nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of cold-induced channel current by whole cell electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
LigandPNGBDBM256299(US9487488, 23)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256310(US9487488, 34)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM50268749(CHEMBL4097005)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM151765(US8987445, 201)
Affinity DataIC50: 0.600nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM256298(US9487488, 22)
Affinity DataIC50: 0.600nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256301(US9487488, 25)
Affinity DataIC50: 0.700nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256314(US9487488, 38)
Affinity DataIC50: 0.700nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256278(US9487488, 2)
Affinity DataIC50: 0.700nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM50268746(CHEMBL4097943)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM256290(US9487488, 14)
Affinity DataIC50: 0.700nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256303(US9487488, 27)
Affinity DataIC50: 0.800nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human TRMP8 incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50268828(CHEMBL4079591)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM151774(US8987445, 210)
Affinity DataIC50: 0.800nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM151797(US8987445, 233)
Affinity DataIC50: 0.900nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM256294(US9487488, 18)
Affinity DataIC50: 0.900nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM151677(US8987445, 104)
Affinity DataIC50: 0.900nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM50036542(CHEMBL3353600)
Affinity DataIC50: 0.960nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
LigandPNGBDBM256302(US9487488, 26)
Affinity DataIC50: 1nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256283(US9487488, 7)
Affinity DataIC50: 1nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256328(US9487488, 52)
Affinity DataIC50: 1nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM151745(US8987445, 181)
Affinity DataIC50: 1nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM151773(US8987445, 209)
Affinity DataIC50: 1nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells measured after 24 hrs of menthol activation by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM151748(US8987445, 184)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM50268729(CHEMBL4060261)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2020
Entry Details Article
PubMed
LigandPNGBDBM256285(US9487488, 9)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256317(US9487488, 41)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256280(US9487488, 4)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256297(US9487488, 21)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256306(US9487488, 30)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256307(US9487488, 31)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256300(US9487488, 24)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM151749(US8987445, 185)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM151655(US8987445, 61)
Affinity DataIC50: 1.30nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM151758(US8987445, 194)
Affinity DataIC50: 1.30nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

LigandPNGBDBM151766(US8987445, 202)
Affinity DataIC50: 1.40nMT: 2°CAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

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