Compile Data Set for Download or QSAR
Report error Found 928 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 4'
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50426556(CHEMBL2323962)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity at TRPV4 (unknown origin) by ligand-gated assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50426558(CHEMBL2323960)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity at TRPV4 (unknown origin) by ligand-gated assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50426557(CHEMBL2323961)
Affinity DataIC50: 0.00100nMAssay Description:Antagonist activity at TRPV4 (unknown origin) by ligand-gated assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264847(CHEMBL4096902)
Affinity DataIC50: 0.180nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50256209(CHEMBL4101768)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264846(CHEMBL4066531)
Affinity DataIC50: 0.210nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192809(CHEMBL3941914)
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192809(CHEMBL3941914)
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50256228(CHEMBL4099293)
Affinity DataIC50: 0.290nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192811(CHEMBL3971502)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192811(CHEMBL3971502)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50521182(CHEMBL4456312 | US11260049, Ex. 123)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264858(CHEMBL4077638)
Affinity DataIC50: 0.310nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50521995(CHEMBL4578182)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192807(CHEMBL3984947)
Affinity DataIC50: 0.360nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264859(CHEMBL4078117)
Affinity DataIC50: 0.390nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192809(CHEMBL3941914)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192809(CHEMBL3941914)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of hypotonicity-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50502628(CHEMBL4469630)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM50545036(CHEMBL4632531)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at mouse TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50521192(CHEMBL4547537 | US11260049, Ex. 121)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50521183(CHEMBL4461475 | US11260049, Ex. 125)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264845(CHEMBL4095552)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192804(CHEMBL3933401)
Affinity DataIC50: 0.570nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50256212(CHEMBL4060956)
Affinity DataIC50: 0.620nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264848(CHEMBL4062935)
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264857(CHEMBL4090714)
Affinity DataIC50: 0.710nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50522021(CHEMBL4465116)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50521996(CHEMBL4459940)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264856(CHEMBL4084992)
Affinity DataIC50: 0.870nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192820(CHEMBL3950646)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50256230(CHEMBL4083772)
Affinity DataIC50: 0.970nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264855(CHEMBL4091558)
Affinity DataIC50: 0.990nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at TRPV4 (unknown origin) assessed as inhibition of capsaicin induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50521183(CHEMBL4461475 | US11260049, Ex. 125)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at rat TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50450513(CHEMBL4168219)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192808(CHEMBL3915150)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50521996(CHEMBL4459940)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50192779(CHEMBL3957347)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50502648(CHEMBL4588831)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50521995(CHEMBL4578182)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50502635(CHEMBL4521512)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50554960(CHEMBL4749555)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human TRPV4 expressed in BHK or HEK MSR2 cells assessed as inhibition of TRPV4 agonist GSK634775 (EC80)-induced response incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50264844(CHEMBL4069724)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50256210(CHEMBL4080527)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50263440(CHEMBL4083195)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50502626(CHEMBL4536058)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50502649(CHEMBL4532369)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM50232815(CHEMBL4104743)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50502640(CHEMBL4470585)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of rat TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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