Compile Data Set for Download or QSAR
Report error Found 859 Enz. Inhib. hit(s) with Target = 'Tyrosyl-DNA phosphodiesterase 2'
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437709BDBM437709(US10617706, Example 143)
Affinity DataIC50: 3.85nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437686BDBM437686(US10617706, Example 120)
Affinity DataIC50: 5.01nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437707BDBM437707(US10617706, Example 141)
Affinity DataIC50: 6.09nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521692BDBM50521692(CHEMBL4441013)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437708BDBM437708(US10617706, Example 142)
Affinity DataIC50: 6.49nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521699BDBM50521699(CHEMBL4572376)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437703BDBM437703(US10617706, Example 137)
Affinity DataIC50: 7.25nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521689BDBM50521689(CHEMBL4436202)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437685BDBM437685(US10617706, Example 119)
Affinity DataIC50: 8.28nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437705BDBM437705(US10617706, Example 139)
Affinity DataIC50: 13.6nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521691BDBM50521691(CHEMBL4587441)
Affinity DataIC50: 14nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437704BDBM437704(US10617706, Example 138)
Affinity DataIC50: 19.8nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521690BDBM50521690(CHEMBL4520052)
Affinity DataIC50: 20nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 188529BDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 25nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 188529BDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 29nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438854BDBM50438854(CHEMBL2420474)
Affinity DataEC50:  30nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437694BDBM437694(US10617706, Example 128)
Affinity DataIC50: 32.8nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521687BDBM50521687(CHEMBL4560735)
Affinity DataIC50: 33nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521697BDBM50521697(CHEMBL4468174)
Affinity DataIC50: 33nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 188529BDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 33nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437692BDBM437692(US10617706, Example 126)
Affinity DataIC50: 33.1nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521698BDBM50521698(CHEMBL4555612)
Affinity DataIC50: 35nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437697BDBM437697(US10617706, Example 131)
Affinity DataIC50: 35nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521678BDBM50521678(CHEMBL4521151)
Affinity DataIC50: 38nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437696BDBM437696(US10617706, Example 130)
Affinity DataIC50: 38nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437689BDBM437689(US10617706, Example 123)
Affinity DataIC50: 39nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50518351BDBM50518351(CHEMBL4470500)
Affinity DataIC50: 40nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 188529BDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 40nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438848BDBM50438848(CHEMBL2420480)
Affinity DataEC50:  40nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438848BDBM50438848(CHEMBL2420480)
Affinity DataIC50: 41nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438864BDBM50438864(CHEMBL2420507)
Affinity DataIC50: 42nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437687BDBM437687(US10617706, Example 121)
Affinity DataIC50: 47nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438894BDBM50438894(CHEMBL2420481)
Affinity DataEC50:  50nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438864BDBM50438864(CHEMBL2420507)
Affinity DataEC50:  50nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437699BDBM437699(US10617706, Example 133)
Affinity DataIC50: 59nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438863BDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 62nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437695BDBM437695(US10617706, Example 129)
Affinity DataIC50: 64.7nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521701BDBM50521701(CHEMBL4457155)
Affinity DataIC50: 65nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521688BDBM50521688(CHEMBL4546104)
Affinity DataIC50: 70nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437693BDBM437693(US10617706, Example 127)
Affinity DataIC50: 70.4nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438856BDBM50438856(CHEMBL2420472)
Affinity DataEC50:  90nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438863BDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataEC50:  90nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437702BDBM437702(US10617706, Example 136)
Affinity DataIC50: 119nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437698BDBM437698(US10617706, Example 132)
Affinity DataIC50: 119nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438914BDBM50438914(CHEMBL2420614)
Affinity DataEC50:  120nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521702BDBM50521702(CHEMBL4518508)
Affinity DataIC50: 130nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 437683BDBM437683(US10617706, Example 117)
Affinity DataIC50: 131nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438863BDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 140nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50438863BDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 140nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandChemical structure of BindingDB Monomer ID 50521683BDBM50521683(CHEMBL4576353)
Affinity DataIC50: 150nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
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