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Found 3887 with Last Name = 'davenport' and Initial = 'a'
TargetEndothelin-1 receptor(Homo sapiens (Human))
University of Cambridge

Curated by PDSP Ki Database
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
University of Cambridge

Curated by PDSP Ki Database
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
University of Cambridge

Curated by PDSP Ki Database
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataKi:  0.920nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245983((2R,3S,4S)-2-Ethyl-3-methyl-N-[3,5-(chloro)phenyl]...)
Affinity DataKi:  70nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245937((2R,3S,4S)-N-(3-bromophenyl)-2-ethyl-3-methyl-4-(p...)
Affinity DataKi:  100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50246518(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataKi:  100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245772((4-bromophenyl)((2R,3S,4S)-2-ethyl-3-methyl-4-(phe...)
Affinity DataKi:  100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50321586(1-(2-(2-isopropylphenyl)benzofuran-7-yl)-3-(4-pent...)
Affinity DataKi:  140nMAssay Description:Displacement of [33P]2-MeS-ADP from human P2Y1 receptor expressed in human U2OS cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245982((2R,3S,4S)-N-(3,5-dimethoxyphenyl)-2-ethyl-3-methy...)
Affinity DataKi:  200nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245934((2R,3S,4S)-N-(4-chlorophenyl)-2-ethyl-3-methyl-4-(...)
Affinity DataKi:  300nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245835((2R,3S,4S)-N-(3-chlorophenyl)-2-ethyl-3-methyl-4-(...)
Affinity DataKi:  300nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50321585(1-(2-(2-tert-butylphenyl)benzofuran-7-yl)-3-(4-(tr...)
Affinity DataKi:  400nMAssay Description:Displacement of [33P]2-MeS-ADP from human P2Y1 receptor expressed in human U2OS cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245981((2R,3S,4S)-2-ethyl-3-methyl-N-phenyl-4-(phenylamin...)
Affinity DataKi:  400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50246516(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataKi:  400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50246517((4-chlorophenyl)((2R,3S,4S)-2-ethyl-3-methyl-4-(ph...)
Affinity DataKi:  400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50246468(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataKi:  500nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245935((2R,3S,4S)-2-ethyl-N-(3-methoxyphenyl)-3-methyl-4-...)
Affinity DataKi:  500nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
University of Cambridge

Curated by PDSP Ki Database
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataKi:  570nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50321584(1-(2-(2-isopropylphenyl)benzofuran-7-yl)-3-(4-(tri...)
Affinity DataKi:  600nMAssay Description:Displacement of [33P]2-MeS-ADP from human P2Y1 receptor expressed in human U2OS cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50321587(1-(4-butoxyphenyl)-3-(2-(2-isopropylphenyl)benzofu...)
Affinity DataKi:  640nMAssay Description:Displacement of [33P]2-MeS-ADP from human P2Y1 receptor expressed in human U2OS cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50321588(1-(4-chlorophenyl)-3-(2-(2-isopropylphenyl)benzofu...)
Affinity DataKi:  760nMAssay Description:Displacement of [33P]2-MeS-ADP from human P2Y1 receptor expressed in human U2OS cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50245984(CHEMBL516508 | cis-(2(R)-ethyl-4-(phenylamino)-3,4...)
Affinity DataKi:  800nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
University of Cambridge

Curated by PDSP Ki Database
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataKi:  1.42E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50321583(1-(4-(trifluoromethoxy)phenyl)-3-(2-(2-(trifluorom...)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [33P]2-MeS-ADP from human P2Y1 receptor expressed in human U2OS cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
University of Cambridge

Curated by PDSP Ki Database
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325090(1-((1-benzyl-1H-tetrazol-5-yl)(4-(2-methyl-1H-imid...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325082(4-((1-benzyl-1H-tetrazol-5-yl)(4-cyclobutyl-1,4-di...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325065(1-((1-benzyl-1H-tetrazol-5-yl)(4-((4-methylpiperaz...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325065(1-((1-benzyl-1H-tetrazol-5-yl)(4-((4-methylpiperaz...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325092(4-(4-((1-benzyl-1H-tetrazol-5-yl)(4-cyclobutyl-1,4...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325087(1-((1-benzyl-1H-tetrazol-5-yl)(4-(4-methylpiperazi...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325086(4-(4-((1-benzyl-1H-tetrazol-5-yl)(4-cyclobutyl-1,4...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325094(1-((4-((1H-pyrazol-1-yl)methyl)phenyl)(1-benzyl-1H...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325096(1-((1-benzyl-1H-tetrazol-5-yl)(4-(pyridin-2-yloxy)...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319931(3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H...)
Affinity DataIC50:  1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319931(3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H...)
Affinity DataIC50:  1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319931(3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H...)
Affinity DataIC50:  1nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319931(3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H...)
Affinity DataIC50:  1nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325089(1-((4-(1H-pyrazol-1-yl)phenyl)(1-benzyl-1H-tetrazo...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325066(1-((4-(1H-1,2,4-triazol-1-yl)phenyl)(1-benzyl-1H-t...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50325064(1-((1-benzyl-1H-tetrazol-5-yl)(4-(methylsulfonyl)p...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319928(N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (...)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320052(3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta...)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320111(3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydro...)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319932(N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5...)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319936(3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-...)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319928(N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (...)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319932(N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5...)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM319936(3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-...)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM320041(US10174016, Example 208)
Affinity DataIC50:  2nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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