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Found 133 with Last Name = 'yokomizo' and Initial = 'a'
TargetCoagulation factor X(Oryctolagus cuniculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataKi:  1.74nMAssay Description:Inhibition of rabbit factor 10a by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataKi:  2.85nMAssay Description:Inhibition of human factor 10a by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetCoagulation factor X(Rattus norvegicus (rat))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataKi:  8.77nMAssay Description:Inhibition of rat factor 10a by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi:  41nMAssay Description:Inhibition of human factor 10a by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataKi:  2.54E+3nMAssay Description:Inhibition of human thrombin by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition of human recombinant tissue plasminogen activator by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of human plasmin by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataKi:  6.82E+4nMAssay Description:Inhibition of human recombinant tissue plasminogen activator by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant factor 7a/soluble tissue factor by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human plasmin by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of human thrombin by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338903(CHEMBL1684849 | Ethyl 1-{4-[{4-chloro-2-[(2-fluoro...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338880(CHEMBL1684826 | Ethyl 1-{4-[{4-chloro-2-[(2-chloro...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338892(Benzyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338910(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338907(CHEMBL1684996 | Ethyl 1-{4-[{4-chloro-2-[hydroxy(2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338883(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338919(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338934(1-{4-[{4-Chloro-2-[hydroxy(2-methoxyphenyl)methyl]...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351091(CHEMBL1819577)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351073(CHEMBL1819477)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35751(cis-1,2-diaminocyclohexane derivative, 8h)
Affinity DataIC50:  1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351081(CHEMBL1819567)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351083(CHEMBL1819569)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338887(CHEMBL1684833 | N-Butyl-1-{4-[{4-chloro-2-[(2-chlo...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351079(CHEMBL1819565)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338925(1-{4-[{4-Chloro-2-[hydroxy(2-methoxyphenyl)methyl]...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255631(CHEMBL516922 | N-[(1R,2R,5S)-2-{[(5-Chloroindol-2-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338937(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50:  2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338905(CHEMBL1684994 | Ethyl 1-{4-[{4-chloro-2-[(2-chloro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35756(cis-1,2-diaminocyclohexane derivative, 8m)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255577(CHEMBL473243 | N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50:  2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255205(CHEMBL508906 | N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338891(CHEMBL1684837 | Ethyl 4-{4-[{4-chloro-2-[(2-chloro...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351094(CHEMBL1819580)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338885(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351077(CHEMBL1819563)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255207(CHEMBL474459 | N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351092(CHEMBL1819578)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338916(CHEMBL1685005 | Ethyl 1-{4-[{4-chloro-2-[hydroxy(2...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255159(CHEMBL515569 | N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338928(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255204(CHEMBL515895 | N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351088(CHEMBL1819574)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351088(CHEMBL1819574)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM35759(cis-1,2-diaminocyclohexane derivative, 8p)
Affinity DataIC50:  3.20nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351085(CHEMBL1819571)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351075(CHEMBL1819561)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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