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Found 376 with Last Name = 'moore' and Initial = 'ag'
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50257636(5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-...)
Affinity DataKi:  1.00E+8nMAssay Description:Inhibition of 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50257636(5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-...)
Affinity DataKi:  1.00E+8nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50257636(5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-...)
Affinity DataKi:  1.00E+8nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50257636(5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-...)
Affinity DataKi:  1.00E+8nMAssay Description:Inhibition of 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50040728(CHEMBL3353219 | US9255110, 1)
Affinity DataIC50:  1nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206090(US9255110, 2)
Affinity DataIC50:  2nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206091(US9255110, 3)
Affinity DataIC50:  3nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206092(US9255110, 4)
Affinity DataIC50:  4nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206093(US9255110, 5)
Affinity DataIC50:  5nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50413370(CHEMBL495204)
Affinity DataIC50:  6.30nMAssay Description:Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206094(US9255110, 6)
Affinity DataIC50:  7nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(CHEMBL3353220 | US9255110, 7)
Affinity DataIC50:  8nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206095(US9255110, 8)
Affinity DataIC50:  8nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206096(US9255110, 9)
Affinity DataIC50:  9nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206098(US9255110, 11)
Affinity DataIC50:  10nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50257636(5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206097(US9255110, 10)
Affinity DataIC50:  10nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206099(US9255110, 12)
Affinity DataIC50:  11nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206100(US9255110, 13)
Affinity DataIC50:  12nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206101(US9255110, 14)
Affinity DataIC50:  12nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 2(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50413370(CHEMBL495204)
Affinity DataIC50:  13nMAssay Description:Inhibition of P2X2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206102(US9255110, 15)
Affinity DataIC50:  15nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206098(US9255110, 11)
Affinity DataIC50:  17nMpH: 7.2 T: 2°CAssay Description:SYK activity is measured by phosphorylation of a peptide substrate (Biotin-EPEGDYEEVLE) with [gamma-33P] ATP. The enzyme reaction was conducted at 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206104(US9255110, 17)
Affinity DataIC50:  18nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206103(US9255110, 16)
Affinity DataIC50:  18nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50413395(CHEMBL495203)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206105(US9255110, 18)
Affinity DataIC50:  23nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206108(US9255110, 21)
Affinity DataIC50:  24nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206106(US9255110, 19)
Affinity DataIC50:  24nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206107(US9255110, 20)
Affinity DataIC50:  24nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50413394(CHEMBL448525)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50413382(CHEMBL494833)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206109(US9255110, 22)
Affinity DataIC50:  28nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206110(US9255110, 23)
Affinity DataIC50:  29nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206111(US9255110, 24)
Affinity DataIC50:  29nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 26 | US9255110, 27 | US...)
Affinity DataIC50:  31nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 26 | US9255110, 27 | US...)
Affinity DataIC50:  31nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 26 | US9255110, 27 | US...)
Affinity DataIC50:  31nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50415550(CHEMBL599760 | Ro-85)
Affinity DataIC50:  31.6nMAssay Description:Antagonist activity at rat P2X3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206116(US9255110, 29)
Affinity DataIC50:  33nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206115(US9255110, 28)
Affinity DataIC50:  33nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206117(US9255110, 30)
Affinity DataIC50:  35nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206112(US9255110, 25 | US9255110, 26 | US9255110, 27 | US...)
Affinity DataIC50:  37nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50415601(CHEMBL598103)
Affinity DataIC50:  39.8nMAssay Description:Antagonist activity at rat P2X3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50415553(CHEMBL605130)
Affinity DataIC50:  39.8nMAssay Description:Antagonist activity at rat P2X3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50413400(CHEMBL521983)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206119(US9255110, 32)
Affinity DataIC50:  40nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 3(RAT)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50413377(CHEMBL494176)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206120(US9255110, 33)
Affinity DataIC50:  43nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM206122(US9255110, 35)
Affinity DataIC50:  49nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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