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Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317217((2R)-N-(adamantan-2-yl)-1-(2,2,2-trifluoroethyl)py...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317211((2R)-N-(adamantan-2-yl)-1-propylpyrrolidine-2-carb...)
Affinity DataKi:  1nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317224((2R)-N-(adamantan-2-yl)-1-(oxan-4-ylmethyl)pyrroli...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317221((2R)-N-(adamantan-2-yl)-1-[(3-cyanophenyl)methyl]p...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317213((2R)-N-(adamantan-2-yl)-1-(cyclopentylmethyl)pyrro...)
Affinity DataKi:  1nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317218((2R)-N-(adamantan-2-yl)-1-(3,3,3-trifluoropropyl)p...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317223((2R)-N-(adamantan-2-yl)-1-(pyridin-2-yl)pyrrolidin...)
Affinity DataKi:  1nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317209((2R)-N-(adamantan-2-yl)-1-ethylpyrrolidine-2-carbo...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317211((2R)-N-(adamantan-2-yl)-1-propylpyrrolidine-2-carb...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317212((2R)-N-(adamantan-2-yl)-1-(propan-2-yl)pyrrolidine...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317219((2R)-N-(adamantan-2-yl)-1-[(4-chlorophenyl)methyl]...)
Affinity DataKi:  2nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317210((2R)-N-(adamantan-2-yl)-1-methylpyrrolidine-2-carb...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317216((2R)-N-(adamantan-2-yl)-1-(cyclohexylmethyl)pyrrol...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317208(CHEMBL1088115 | N-(adamantan-2-yl)-2-[cyclohexyl(e...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317216((2R)-N-(adamantan-2-yl)-1-(cyclohexylmethyl)pyrrol...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317218((2R)-N-(adamantan-2-yl)-1-(3,3,3-trifluoropropyl)p...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317222((2R)-N-(adamantan-2-yl)-1-(2-hydroxyethyl)pyrrolid...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317210((2R)-N-(adamantan-2-yl)-1-methylpyrrolidine-2-carb...)
Affinity DataKi:  5.40nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317219((2R)-N-(adamantan-2-yl)-1-[(4-chlorophenyl)methyl]...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317212((2R)-N-(adamantan-2-yl)-1-(propan-2-yl)pyrrolidine...)
Affinity DataKi:  9.40nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317207(CHEMBL1088517 | N-cyclohexyl-2-(7,8-dihydro-4H-iso...)
Affinity DataKi:  15nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317224((2R)-N-(adamantan-2-yl)-1-(oxan-4-ylmethyl)pyrroli...)
Affinity DataKi:  16nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317225((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclopentyl)m...)
Affinity DataKi:  17nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317217((2R)-N-(adamantan-2-yl)-1-(2,2,2-trifluoroethyl)py...)
Affinity DataKi:  35.2nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317223((2R)-N-(adamantan-2-yl)-1-(pyridin-2-yl)pyrrolidin...)
Affinity DataKi:  40nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317226((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclohexyl)me...)
Affinity DataKi:  48nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317221((2R)-N-(adamantan-2-yl)-1-[(3-cyanophenyl)methyl]p...)
Affinity DataKi:  170nMAssay Description:Inhibition of mouse 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317206((3-Phenyl-adamantan-1-yl)-piperidin-1-yl-methanone...)
Affinity DataKi:  175nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50317206((3-Phenyl-adamantan-1-yl)-piperidin-1-yl-methanone...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 11-beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317214((2R)-N-(adamantan-2-yl)-1-(2-methylpropyl)pyrrolid...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317215((2R)-N-(adamantan-2-yl)-1-(cyclobutylmethyl)pyrrol...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317220((2R)-N-(adamantan-2-yl)-1-[(4-cyanophenyl)methyl]p...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317226((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclohexyl)me...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317213((2R)-N-(adamantan-2-yl)-1-(cyclopentylmethyl)pyrro...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317216((2R)-N-(adamantan-2-yl)-1-(cyclohexylmethyl)pyrrol...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317217((2R)-N-(adamantan-2-yl)-1-(2,2,2-trifluoroethyl)py...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317221((2R)-N-(adamantan-2-yl)-1-[(3-cyanophenyl)methyl]p...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317219((2R)-N-(adamantan-2-yl)-1-[(4-chlorophenyl)methyl]...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317218((2R)-N-(adamantan-2-yl)-1-(3,3,3-trifluoropropyl)p...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317225((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclopentyl)m...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 23°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM25142((3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-...)
Affinity DataIC50:  1nMpH: 7.5 T: 23°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184105(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  1.01nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317211((2R)-N-(adamantan-2-yl)-1-propylpyrrolidine-2-carb...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184109(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)
Affinity DataIC50:  1.64nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184153(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  1.68nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184111(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)
Affinity DataIC50:  1.75nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184165(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  1.78nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  1.80nMpH: 7.5 T: 23°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184118(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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