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Found 77 with Last Name = 'hengerer' and Initial = 'b'
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM22167(1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)pip...)
Affinity DataIC50:  3.70nMAssay Description:Compound was tested for its ability to inhibit the uptake of [3H]-dopamine in DAT (dopamine transporter system) expressing cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  4.30nMAssay Description:Compound was tested for its ability to inhibit the uptake of [3H]-dopamine in DAT (dopamine transporter system) expressing cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  7nMAssay Description:Binding affinity of the compound towards human Caspase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145661((S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl...)
Affinity DataIC50:  10nMAssay Description:Binding affinity of the compound towards human Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  13nMAssay Description:Binding affinity of the compound towards human Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145661((S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl...)
Affinity DataIC50:  27nMAssay Description:Binding affinity of the compound towards mouse Caspase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  33nMAssay Description:Binding affinity of the compound towards mouse Caspase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  37nMAssay Description:Binding affinity of the compound towards human Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145670((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataIC50:  135nMAssay Description:Binding affinity of the compound towards human Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  160nMAssay Description:Binding affinity of the compound towards human Caspase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145661((S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl...)
Affinity DataIC50:  179nMAssay Description:Binding affinity of the compound towards human Caspase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145661((S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl...)
Affinity DataIC50:  230nMAssay Description:Binding affinity of the compound towards human Caspase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM22167(1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)pip...)
Affinity DataIC50:  289nMAssay Description:Compound was tested for its ability to inhibit the uptake of Serotonin in Serotonin transporter systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145670((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataIC50:  570nMAssay Description:Binding affinity of the compound towards mouse Caspase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145670((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataIC50:  770nMAssay Description:Binding affinity of the compound towards human Caspase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145670((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataIC50:  940nMAssay Description:Binding affinity of the compound towards human Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM22167(1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)pip...)
Affinity DataIC50:  1.26E+3nMAssay Description:Compound was tested for its ability to inhibit the uptake of Norepinephrine in Norepinephrine transporter systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145661((S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl...)
Affinity DataIC50:  1.50E+3nMAssay Description:Binding affinity of the compound towards human Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145670((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataIC50:  2.72E+3nMAssay Description:Binding affinity of the compound towards human Caspase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323546(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323547(CHEMBL1209432 | N-methyl-4-styrylpyrimidin-2-amine)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323548(CHEMBL1209433 | N,N-dimethyl-4-styrylpyrimidin-2-a...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323549(CHEMBL1209434 | N-(4-styrylpyrimidin-2-yl)methanes...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323550(2-methyl-4-styrylpyrimidine | CHEMBL1209435)
Affinity DataEC50:  6.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323551(2-phenyl-4-styrylpyrimidine | CHEMBL1209436)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323552(4-styrylpyrimidine-2-thiol | CHEMBL1209437)
Affinity DataEC50:  7.80E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323553(4-methyl-6-styrylpyrimidin-2-amine | CHEMBL1209438)
Affinity DataEC50:  800nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323554(5-methyl-4-styrylpyrimidin-2-amine | CHEMBL1209514)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323555(4,5-dimethyl-6-styrylpyrimidin-2-amine | CHEMBL120...)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323556(6-styrylpyrimidine-2,4-diamine | CHEMBL1209516)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323557(2-amino-6-styrylpyrimidin-4-ol | CHEMBL1209517)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323558(4-methoxy-6-styrylpyrimidin-2-amine | CHEMBL120951...)
Affinity DataEC50:  2.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323559(4-styryl-6-(trifluoromethyl)pyrimidin-2-amine | CH...)
Affinity DataEC50:  600nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323560(5-chloro-4-styrylpyrimidin-2-amine | CHEMBL1209520)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323561(5-bromo-4-styrylpyrimidin-2-amine | CHEMBL1209521)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323562(6-styrylpyridin-2-amine | CHEMBL1209588)
Affinity DataEC50:  5.80E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323563(6-styrylpyrazin-2-amine | CHEMBL1209589)
Affinity DataEC50:  1.58E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323564(4-phenethylpyrimidin-2-amine | CHEMBL1209590)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323565(4-(phenylethynyl)pyrimidin-2-amine | CHEMBL1209591)
Affinity DataEC50:  2.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323566(5-((1R,2R)-2-phenylcyclopropyl)pyrimidin-2-amine |...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323567(4-(benzofuran-2-yl)pyrimidin-2-amine | CHEMBL12095...)
Affinity DataEC50:  4.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323568(4-(benzo[b]thiophen-2-yl)pyrimidin-2-amine | CHEMB...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323569(4-(naphthalen-2-yl)pyrimidin-2-amine | CHEMBL12095...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323570(4-(2-fluorostyryl)pyrimidin-2-amine | CHEMBL120880...)
Affinity DataEC50:  2.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323571(4-(3-fluorostyryl)pyrimidin-2-amine | CHEMBL120966...)
Affinity DataEC50:  4.50E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323572(4-(4-fluorostyryl)pyrimidin-2-amine | CHEMBL120966...)
Affinity DataEC50:  4.50E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323573(2-(2-(2-aminopyrimidin-4-yl)vinyl)benzonitrile | C...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50323574(3-(2-(2-aminopyrimidin-4-yl)vinyl)benzonitrile | C...)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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