TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Compound was tested for its ability to inhibit the uptake of [3H]-dopamine in DAT (dopamine transporter system) expressing cell lineMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Compound was tested for its ability to inhibit the uptake of [3H]-dopamine in DAT (dopamine transporter system) expressing cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Binding affinity of the compound towards human Caspase-8More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Binding affinity of the compound towards human Caspase-3More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Binding affinity of the compound towards human Caspase-3More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Binding affinity of the compound towards mouse Caspase-1More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Binding affinity of the compound towards mouse Caspase-1More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Binding affinity of the compound towards human Caspase-6More data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:Binding affinity of the compound towards human Caspase-3More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Binding affinity of the compound towards human Caspase-9More data for this Ligand-Target Pair
Affinity DataIC50: 179nMAssay Description:Binding affinity of the compound towards human Caspase-8More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Binding affinity of the compound towards human Caspase-9More data for this Ligand-Target Pair
Affinity DataIC50: 289nMAssay Description:Compound was tested for its ability to inhibit the uptake of Serotonin in Serotonin transporter systemMore data for this Ligand-Target Pair
Affinity DataIC50: 570nMAssay Description:Binding affinity of the compound towards mouse Caspase-1More data for this Ligand-Target Pair
Affinity DataIC50: 770nMAssay Description:Binding affinity of the compound towards human Caspase-8More data for this Ligand-Target Pair
Affinity DataIC50: 940nMAssay Description:Binding affinity of the compound towards human Caspase-6More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: 1.26E+3nMAssay Description:Compound was tested for its ability to inhibit the uptake of Norepinephrine in Norepinephrine transporter systemMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Binding affinity of the compound towards human Caspase-6More data for this Ligand-Target Pair
Affinity DataIC50: 2.72E+3nMAssay Description:Binding affinity of the compound towards human Caspase-9More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 6.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 7.80E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 800nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 600nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 5.80E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 1.58E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 4.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 2.90E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 4.50E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: 4.50E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair