Compile Data Set for Download or QSAR
maximum 50k data
Found 138 with Last Name = 'morton' and Initial = 'b'
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036132(15-chloromethyl-8-ethyl-8-hydroxy-(8S)-2,3,8,9,12,...)
Affinity DataIC50:  11nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036129(14-chloromethyl-7-ethyl-7-hydroxy-(7S)-7,8,11,13-t...)
Affinity DataIC50:  15nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034013((S)-9-Bromo-4-ethyl-4-hydroxy-11-methyl-1,12-dihyd...)
Affinity DataIC50:  28nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036133(7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1...)
Affinity DataIC50:  30nMAssay Description:Ability to inhibit calf thymus topoisomerase I when assayed in the cleavable complex formationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034009((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  33nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137423(2-(4-Chloro-3-difluoromethyl-5-phenyl-pyrazol-1-yl...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137438(5-Methanesulfonyl-2-[5-(4-methoxy-phenyl)-3-triflu...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137420(2-[5-(4-Ethoxy-phenyl)-3-trifluoromethyl-pyrazol-1...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137442(2-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137439(2-[5-(2-Fluoro-4-methoxy-phenyl)-3-trifluoromethyl...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137435(2-(4-Chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-y...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137424(2-[4-Chloro-5-(3-chloro-4-methoxy-phenyl)-3-difluo...)
Affinity DataIC50:  62nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137411(2-[3-Difluoromethyl-5-(4-methoxy-phenyl)-pyrazol-1...)
Affinity DataIC50:  64nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137437(5-Methanesulfonyl-2-[5-(4-methylsulfanyl-phenyl)-3...)
Affinity DataIC50:  69nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034018((S)-4,11-Diethyl-4,N-dihydroxy-3,13-dioxo-3,4,12,1...)
Affinity DataIC50:  71nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036133(7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1...)
Affinity DataIC50:  78nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137427(2-(4-Bromo-3-difluoromethyl-5-phenyl-pyrazol-1-yl)...)
Affinity DataIC50:  80nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137440(CHEMBL176934 | {4-[2-(5-Methanesulfonyl-pyridin-2-...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137414(2-[5-(4-Chloro-phenyl)-3-difluoromethyl-pyrazol-1-...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137428(2-[3-Difluoromethyl-5-(4-methylsulfanyl-phenyl)-py...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034019((S)-9-Bromo-4,11-diethyl-4-hydroxy-1,12-dihydro-4H...)
Affinity DataIC50:  122nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137420(2-[5-(4-Ethoxy-phenyl)-3-trifluoromethyl-pyrazol-1...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034014((S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-3,4,12,...)
Affinity DataIC50:  143nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50285229(7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1...)
Affinity DataIC50:  150nMAssay Description:Ability to inhibit calf thymus topoisomerase I when assayed in the cleavable complex formationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034015((S)-9-Aminomethyl-4,11-diethyl-4-hydroxy-1,12-dihy...)
Affinity DataIC50:  167nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137412(5-Methanesulfonyl-2-(4-methyl-5-phenyl-3-trifluoro...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137434(2-[3-Difluoromethyl-5-(4-methoxy-3-methyl-phenyl)-...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50285230((S)-9-Amino-4-ethyl-4,8-dihydroxy-1,12-dihydro-4H-...)
Affinity DataIC50:  170nMAssay Description:Ability to inhibit calf thymus topoisomerase I when assayed in the cleavable complex formationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137418(2-(3-Difluoromethyl-5-p-tolyl-pyrazol-1-yl)-5-meth...)
Affinity DataIC50:  180nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034020((S)-9-Aminomethyl-4-ethyl-4-hydroxy-11-methyl-8-ox...)
Affinity DataIC50:  190nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137432(2-(3-Difluoromethyl-4-methyl-5-phenyl-pyrazol-1-yl...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137411(2-[3-Difluoromethyl-5-(4-methoxy-phenyl)-pyrazol-1...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034024(((S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-8-oxy-...)
Affinity DataIC50:  217nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034010((S)-9-Aminomethyl-4-ethyl-4-hydroxy-11-methyl-1,12...)
Affinity DataIC50:  232nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137416(2-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  240nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137413(2-[5-(4-Chloro-phenyl)-3-trifluoromethyl-pyrazol-1...)
Affinity DataIC50:  250nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034016((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  268nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137415(5-Methanesulfonyl-2-[5-(4-methoxy-3-methyl-phenyl)...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137410(2-[5-(4-Bromo-phenyl)-3-difluoromethyl-pyrazol-1-y...)
Affinity DataIC50:  290nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137441(2-[5-(3-Chloro-4-methoxy-phenyl)-3-trifluoromethyl...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036131(7-ethyl-7-hydroxy-14-(4-methylhexahydro-1-pyraziny...)
Affinity DataIC50:  300nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137429(2-[3-Difluoromethyl-5-(4-fluoro-phenyl)-pyrazol-1-...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137425(2-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)-5-...)
Affinity DataIC50:  310nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137421(2-[5-(3-Fluoro-4-methoxy-phenyl)-3-trifluoromethyl...)
Affinity DataIC50:  310nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137423(2-(4-Chloro-3-difluoromethyl-5-phenyl-pyrazol-1-yl...)
Affinity DataIC50:  330nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137436(2-[5-(3-Chloro-4-methoxy-phenyl)-3-difluoromethyl-...)
Affinity DataIC50:  330nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034011((S)-4,11-Diethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6...)
Affinity DataIC50:  336nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034030((S)-4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,8,12...)
Affinity DataIC50:  383nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137422(2-[3-Difluoromethyl-5-(2-fluoro-4-methoxy-phenyl)-...)
Affinity DataIC50:  390nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50137417(2-[3-Difluoromethyl-5-(4-ethyl-phenyl)-pyrazol-1-y...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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