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Found 218 with Last Name = 'ramachandran' and Initial = 'c'
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50107741(4-[3,5-di(4-difluorophosphonatephenethylcarboxamid...)
Affinity DataKi:  930nMAssay Description:Binding affinity towards the binding site in PTP1B enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50107743([(4-{4-[4-(Difluoro-phosphono-methyl)-phenyl]-buty...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity towards the site of PTP1B enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50069998(Ammonium; [7-(difluoro-phosphono-methyl)-naphthale...)
Affinity DataKi:  9.00E+3nMAssay Description:Compound was evaluated for inhibitory constant against CD45More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50069997(Ammonium; [7-(difluoro-phosphono-methyl)-naphthale...)
Affinity DataKi:  1.60E+4nMAssay Description:Compound was evaluated for inhibitory constant against PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50070004(difluoro(4-hydroxy-2-naphthyl)methylphosphonate)
Affinity DataKi:  9.30E+4nMAssay Description:Compound was evaluated for inhibitory constant against PTP1BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50075312((Difluoro-naphthalen-2-yl-methyl)-phosphonic acid ...)
Affinity DataKi:  1.97E+5nMAssay Description:Compound was evaluated for inhibitory constant against PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50070001(difluoro(1-naphthyl)methylphosphonate)
Affinity DataKi:  2.55E+5nMAssay Description:Compound was evaluated for inhibitory constant against PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13599(3-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  3nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM13599(3-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13599(3-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13599(3-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  3nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50142323(CHEMBL267488 | [(4-{2-Benzotriazol-1-yl-3-[3-bromo...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM13604(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13604(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  5nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50142323(CHEMBL267488 | [(4-{2-Benzotriazol-1-yl-3-[3-bromo...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13603(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  6nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13601(5-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  6nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM13604(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13596(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13600(5-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  10nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50142335(CHEMBL274435 | [(4-{4-Benzotriazol-1-yl-5-[4-(difl...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13595(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13605(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  11nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13595(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro...)
Affinity DataIC50:  11nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50142328(4-{1-Benzotriazol-1-yl-1-[4-(difluoro-phosphono-me...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM13602(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM13596(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13602(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  12nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13596(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro...)
Affinity DataIC50:  13nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50142328(4-{1-Benzotriazol-1-yl-1-[4-(difluoro-phosphono-me...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM13595(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50142324(({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50142335(CHEMBL274435 | [(4-{4-Benzotriazol-1-yl-5-[4-(difl...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13595(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro...)
Affinity DataIC50:  16nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13603(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  17nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50142330(CHEMBL8662 | [(4-{2-Benzothiazol-2-yl-2-benzotriaz...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50142329(({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50142329(({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50142325(CHEMBL273474 | [(4-{2-Benzotriazol-1-yl-3-[4-(difl...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50142330(CHEMBL8662 | [(4-{2-Benzothiazol-2-yl-2-benzotriaz...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13602(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  20nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13601(5-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  20nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13602(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13605(6-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  21nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13597(({4-[(4E)-2-(1,3-benzothiazol-2-yl)-2-(1H-1,2,3-be...)
Affinity DataIC50:  23nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13598(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-2-phenyl-3-(4-...)
Affinity DataIC50:  24nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13598(({4-[2-(1H-1,2,3-benzotriazol-1-yl)-2-phenyl-3-(4-...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50142325(CHEMBL273474 | [(4-{2-Benzotriazol-1-yl-3-[4-(difl...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13600(5-{4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluor...)
Affinity DataIC50:  31nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Waterloo

Curated by ChEMBL
LigandPNGBDBM50142324(({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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